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arterial stiffness as a Cardiovascular Risk Factor in Prostate Cancer Survivors:A Case-Control Study

Journal of Science in Sport and Exercise 2021年第2期3卷 171-178页

作者： Lynnette M.Jones Rebekah Wilson Lee Stoner J.Chris Baldi School of Physical Education Sportand Exercise SciencesUniversity of OtagoPO Box 56DunedinNew Zealand Department of Sport and Exercise Science University of North CarolinaChapel HillNC 27599-8700USA Department of Medicine University of OtagoPO Box 56DunedinNew Zealand

Purpose In New Zealand,prostate cancer (PCa) is the most commonly diagnosed cancer in men and the third most common cause of male cancer *** these patients,the most common non-cancer related cause of death is cardiovascular disease (CVD).Aortic arterial stiffness may be clinically viable solution for detecting and tracking CVD risk factor in PCa *** aim of the study was to determine whether aortic arterial stiffness is increased in PCa survivors compared to age-matched *** Participants recruited for this prospective comparative study were PCa survivors who had completed treatment(other than endocrine therapy) or were on active surveillance compared,or were age-matched non-cancer *** a single 1-h appointment,all participants had measures of aortic arterial stiffness,arterial wave reflection,central blood pressure and body composition *** Ninety-eight men were recruited,51 PCa survivors and 47 *** was no significant between group dif-ference for aortic arterial stiffness[12.0 m/s (SD:1.7) vs.12.0 m/s (SD:1.9),P=0.953,d=0.0].Fat free mass[60.7 kg(SD:4.9) vs.65.1 kg (SD:8.3),P=0.007,d=0.6]and skeletal muscle index[8.6 kg/m2 (SD:0.6) vs.9.0 kg/m2 (SD:0.9),P=0.050,d=0.5]were lower in the PCa *** Aortic arterial stiffness is not increased (worse) in men with PCa who receive various treatments,compared to age-matched *** findings may indicate that factors other than increased aortic arterial stiffness contribute to heightened risk of cardiovascular events in this population.

关键词： Prostate cancer Cardiovascular disease Risk arterial stiffness

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Association between Fruit and Vegetable Intake and arterial stiffness: The China-PAR Project

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Biomedical and Environmental Sciences 2023年第12期36卷 1113-1122页

作者： LIU Shuai LIU Fang Chao LI Jian Xin HUANG Ke Yong YANG Xue Li CHEN Ji Chun CAO Jie CHEN Shu Feng HUANG Jian Feng SHEN Chong LU Xiang Feng GU Dong Feng Department of Epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166JiangsuChina Key Laboratory of Cardiovascular Epidemiology&Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Tianjin Key Laboratory of Environment Nutrition and Public HealthDepartment of Occupational and Environmental HealthSchool of Public HealthTianjin Medical UniversityTianjin 300070China Research Units of Cohort Study on Cardiovascular Diseases and Cancers Chinese Academy of Medical SciencesBeijing 100730China School of Medicine Southern University of Science and TechnologyShenzhen 518055GuangdongChina

Objective This study aimed to investigate the association between fruit and vegetable intake and arterial *** We conducted a cohort-based study comprising 6,628 participants with arterial stiffness information in the Prediction for Atherosclerotic Cardiovascular Disease Risk in China(China-PAR)project. A semi-quantitative food-frequency questionnaire was used to assess baseline(2007–2008) and recent(2018–2021) fruit and vegetable intake. We assessed changes in fruit and vegetable intake from2007–2008 to 2018–2021 in 6,481 participants. arterial stiffness was measured using the arterial velocity–pulse index(AVI) and arterial pressure-volume index(API). Elevated AVI and API values were defined according to diverse age reference *** Multivariable-adjusted linear regression models revealed that every 100 g/d increment in fruit and vegetable intake was associated with a 0.11 decrease in AVI(B =-0.11;95% confidence interval [CI]:-0.20,-0.02) on average, rather than API(B = 0.02;95% CI:-0.09, 0.13). The risk of elevated AVI(odds ratio [OR] = 0.82;95% CI: 0.70, 0.97) is 18% lower in individuals with high intake(≥ 500 g/d) than in those with low intake(arterial stiffness, emphasizing recommendations for adherence to fruit and vegetable intake for the prevention of arterial stiffness.

关键词： Fruit Vegetable arterial stiffness Cardiovascular disease

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Pilot study on the effect of flavonoids on arterial stiffness and oxidative stress in chronic kidney disease

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World Journal of Nephrology 2024年第3期13卷 41-48页

作者： Anastasia Vagopoulou Panagiotis Theofilis Despina Karasavvidou Nasra Haddad Dimitris Makridis Stergios Tzimikas Rigas Kalaitzidis Nephrology Department“C.Katsinas” General Hospital of Ptolemaida“Mpodosakeio”Ptolemaida 50200Greece Center for Nephrology“G.Papadakis” General Hospital of Nikaia-Piraeus“Agios Panteleimon”Nikaia-Piraeus 18454Greece

BACKGROUND Flavonoids,the main class of polyphenols,exhibit antioxidant and antihypertensive *** To prospectively investigate the impact of flavonoids on arterial stiffness in patients with chronic kidney disease(CKD)stagesⅠ-Ⅳ.METHODS In this prospective,single-arm study,CKD patients with arterial hypertension and diabetes mellitus were *** demographic,clinical,and laboratory variables were *** received daily treatment with a phenol-rich dietary supplement for 3 *** pressure,arterial stiffness(carotidfemoral pulse wave velocity,central pulse pressure),and oxidative stress markers(protein carbonyls,total phenolic compound,total antioxidant capacity)were measured at baseline and at study *** Sixteen patients(mean age:62.5 years,87.5%male)completed the *** intervention,peripheral systolic blood pressure decreased significantly by 14 mmHg(Parterial stiffness,and oxidative stress markers.

关键词： Flavonoids Chronic kidney disease arterial stiffness Oxidative stress Carotid-femoral pulse wave velocity

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arterial stiffness, vascular calcification and bone metabolism in chronic kidney disease

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World Journal of Nephrology 2012年第1期1卷 25-34页

作者： János Nemcsik István Kiss András Tislér Department of Family Medicine Semmelweis University 1125 Budapest Hungary Division of Angiology and Nephrology Department of Medicine St. Imre Teaching Hospital 1115 BudapestHungary 1st Department of Medicine Semmelweis University 1125 Budapest Hungary

Patients with chronic kidney disease （CKD） have an extremely poor cardiovascular outcome. arterial stiff-ness, a strong independent predictor of survival in CKD, is connected to arterial media calcification. A huge number of different factors contribute to the increased arterial calcification and stiffening in CKD, a process which is in parallel with impaired bone metabolism. This coincidence was demonstrated to be part of the direct inhibition of calcifcation in the vessels, which is a counterbalancing effect but also leads to low bone turnover. Due to the growing evidence, the defnition of “CKD mineral bone disorder” was created recently, un-derlining the strong connection of the two phenomena. In this review, we aim to demonstrate the mechanisms leading to increased arterial stiffness and the up-to date data of the bone-vascular axis in CKD. We over-view a list of the different factors, including inhibitors of bone metabolism like osteoprotegerin, fetuin-A, pyro-phosphates, matrix Gla protein, osteopontin, fbroblast growth factor 23 and bone morphogenic protein, which seem to play role in the progression of vascular calcif-cation and we evaluate their connection to impaired ar-terial stiffness in the mirror of recent scientifc results.

关键词： arterial stiffness Vascular calcification Bone metabolism Chronic kidney disease

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Association between serum homocysteine and arterial stiffness in elderly： a community-based study

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Journal of Geriatric Cardiology 2014年第1期11卷 32-38页

作者： Song ZHANG Yong-Yi BAI Lei-Ming LUO Wen-Kai XIAO Hong-Mei WU Ping YE Department of Geriatric Cardiology Chinese PLA General Hospital No.28 Fuxing Road Beijing 100853 China School of Medicine Nankai University N0.94 Weijin Road Tianjin 300071 China

Background arterial stiffness and homocysteine are both powerful predictors of cardiovascular disease, especially in older popula tions. Previous studies have investigated the association of homocysteine with arterial stiffness in human subjects, while the relationship between homocysteine and arterial stiffness in the elderly is still indefinite. The current study examined the association of homocysteine with arterial stiffness in Chinese community-based elderly persons. Methods We related serum levels of homocysteine to two measures of arte- rial stiffness （carotid-femoral pulse wave velocity （PWV） and carotid-radial PWV） in 780 participants （46.3% men, mean age 71.9 years （ranging 65-96 years old）） from two communities of Beijing, China. arterial stiffness were measured within two days of the time of bio- marker measurement. Results In multiple-adjusted models, homocysteine levels was strongly associated with the carotid-femoral PWV （standardized 13 = 0.13, P 〈 0.001）, even after adjustment for classical risk factors of cardiovascular disease. The association is also stronger when the carotid-femoral PWV is elevated above normal, whereas no significant association with homocysteine was observed for ca-rotid-radial PWV. Conclusions In Chinese elderly persons, serum homocysteine levels are associated with alterations of aortic stiffness.

关键词： The elderly Homocysteine arterial stiffness Pulse wave velocity

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Intensive blood pressure control on arterial stiffness among older patients with hypertension

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Chinese Medical Journal 2024年第9期137卷 1078-1087页

作者： Shuyuan Zhang Yixuan Zhong Shouling Wu Hailei Wu Jun Cai Weili Zhang On behalf of the STEP Study Group National Clinical Research Center of Cardiovascular Diseases Fuwai HospitalNational Center for Cardiovascular DiseasesPeking Union Medical College&Chinese Academy of Medical SciencesBeijing 100037China Department of Cardiology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesPeking Union Medical College&Chinese Academy of Medical SciencesBeijing 100037China Department of Cardiology Kailuan General HospitalTangshanHebei 063000China Central China Subcenter of National Center for Cardiovascular Diseases Henan Cardiovascular Disease CenterFuwai Central-China Cardiovascular HospitalCentral China Fuwai Hospital of Zhengzhou UniversityZhengzhouHenan 450046China 不详

Background:arterial stiffening increases with age and blood pressure and is associated with cardiovascular disease(CVD),but the relationship between blood pressure lowering and arterial stiffening is still uncertain,especially in older *** study aimed to evaluate the effect of intensive blood pressure treatment on the progression of arterial stiffness and risk of CVD in older patients with ***:The Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients(STEP)trial was a multicenter,randomized,controlled trial performed at 42 clinical centers throughout China,and 8511 patients aged 60-80 years with essential hypertension were enrolled and randomly assigned to systolic blood pressure(SBP)target of 110 mmHg toarterial stiffness was evaluated at the 3-year follow-up.A total of 5339 patients who had twice repeated measurements were included in this *** in arterial stiffness between the intensive and standard treatment groups were analyzed using a multivariate linear regression *** Cox proportional hazard regression model was used to evaluate the effect of intensive treatment on primary CVD ***:The changes in baPWV were 61.5 cm/s(95%confidence interval[CI]:49.8-73.2 cm/s)in the intensive treatment group and 98.4 cm/s(95%CI:86.7-110.1 cm/s)in the standard treatment group(Parterial stiffness,with an annual change of 23.1 cm·s^(-1)·year-1 vs.36.7 cm·s^(-1)·year^(-1)of baPWV in the intensive and standard treatment groups,*** a median follow-up period of 3.36 years,primary CVD outcomes occurred in 77(2.9%)patients in the intensive treatment group compared with 93(3.5%)in the standard treatment *** tre

关键词： Hypertension arterial stiffness Cardiovascular disease Older people Blood pressure Pulse wave velocity

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Relationships between use of statins and arterial stiffness in normotensive and hypertensive patients with coronary artery disease

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Chinese Medical Journal 2013年第16期126卷 3087-3092页

作者： WANG Zhi-guang CHEN Bing-wei L(U) Na-qiang CHENG Yan-mei DANG Ai-min State Key Laboratory of Cardiovascular Disease Department ofCardiology Fuwai Hospital National Center for CardiovascularDiseases Chinese Academy of Medical Sciences and Peking UnionMedical College Beijing 100037 China

Background Statins improve arterial stiffness in patients with coronary artery disease （CAD）.Hypertension is a predominant contributor of arterial ***,the influence of hypertension on the effect of statins for improving arterial stiffness in CAD patients has seldom been ***,in this study,we investigated the relationships between statin use and arterial stiffness in normotensive and hypertensive CAD *** Brachial-ankle pulse wave velocity （ba-PWV） was measured in 437 patients,including 220 hypertensive CAD patients （121 used statins,99 did not） and 217 normotensive CAD patients （105 used statins,112 did not）.The normotensive and hypertensive CAD patients were matched according to age,sex,and body mass index （BMI）.Results In the normotensive and hypertensive CAD patients,lipid profiles were significantly improved in the statin group compared with the non-statin *** significant differences in the administered statins （i.e.,atorvastatin,simvastatin,rosuvastatin,and pravastatin） and statin therapy duration were found between normotensive and hypertensive CAD patients （all P＞0.05）.No significant correlation of ba-PWV and statin therapy duration was found in all CAD patients,normotensive CAD patients,or hypertensive CAD patients （all P＞0.05）.ba-PWV in the statin group was significantly lower than that in the non-statin group in normotensive CAD patients （（1331.68±167.52） cm/s vs.（1468.61±244.54） cm/s,P=0.002） but not in hypertensive CAD patients （P＞0.05）.In multiple linear regression analyses,statin therapy was significantly associated with ba-PWV after adjusting for confounding variables in normotensive CAD patients （P=0.018） but not in hypertensive CAD patients （P＞0.05）.Conclusions Statins may significantly improve arterial stiffness in CAD patients,and hypertension may probably influence the effectiveness of statin therapy in improving arterial stiffness in this *** studies are required to investigate the

关键词： arterial stiffness statins hypertension coronary artery disease

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Increased arterial stiffness in Subjects with Pre-diabetes among Middle Aged Population in Beijing,China

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Biomedical and Environmental Sciences 2013年第9期26卷 717-725页

作者： SHEN Li ZHANG Yan Ge LIU Min WU Liu Xin QIANG Dong Chang SUN Xue Lei LIU Lin JIANG Yuan Yuan Department of Epidemiology and Biostatistics School of Public Health Peking University Health Science Center Institute of Aviation Medicine AF

Objective To investigate the relationship between arterial stiffness and pre-diabetes when assessed by the new glycosylated hemoglobin Ale （HbAlc） 5.7%-6.4% criterion or by impaired fasting glucose in middle aged Chinese. Methods 1122 adults aged 55 years or younger in the health examination centers for physical check-ups were enrolled in the two large-sized Tertiary Comprehensive Hospitals in Beijing from June 2011 to June 2012 after excluding those who previously had been diagnosed or treated as diabetes or cardiovascular disease. Subjects with a diagnosis of pre-diabetes according to impaired fasting glucose （IFG）（fasting plasma glucose （FPG） levels at 5.6-6.9 mmol/L）, HbA^c levels at 5.7%-6.4%, or both, were classified into four groups for observation：（1） Normoglycaemia （HbA^c〈5.7% and FPG 〈5.6 mmol/L）; （2） IFG alone （FPG levels at 5.6-6.9 mmol/L and HbA1c〈5.7% ）; （3） HbAI~ 5.7%-6.4% alone （HbA^c levels at 5.7%-6.4% and FPG 〈5.6 mmol/L）; and （4） both HbA1c 5.7%-6.4% and IFG （l-lbA1~ levels at 5.7%-6.4% and FPG levels at 5.6-6.9 mmol/L）. All subjects were measured for weight, height, waist circumference, blood pressure, fasting plasma glucose, HbA1c, lipid profile and brachial-ankle pulse wave velocity （baPWV）. Results The mean values of baPWV were 1282±8, 1311±10, 1398±30, and 1418_±27 cm/s （Mean_±SE） in Normoglycaemia, HbA~ 5.7%-6.4% alone, IFG alone and the both HbAlc 5.7%-6.4% and IFG groups, respectively. After adjusting for age, gender, blood pressure, BMI and triglyceride, baPWV was significantly higher in subjects with both HbAlc5.7%-6.4% and iFG compared among the subjects with Normoglycaemia （1350±14 vs. 1301±6 cm/s, P=0.002） and HbA1c 5.7%-6.4% alone （1350±14 vs. 1309±8 cm/s, P=0.013）.Conclusion Subjects with pre-diabetes exhibited a greater arterial stiffness.

关键词： Pre-diabetes Vascular stiffness arterial stiffness

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Association between non-alcoholic fatty liver disease and arterial stiffness in the non-obese, non-hypertensive, and non-diabetic young and middle-aged Chinese population

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2014年第10期15卷 879-887页

作者： Xin-yan YU Yi ZHAO Xiao-xiao SONG Zhen-ya SONG International Health Care Center the Second Affiliated Hospital School of Medicine Zhejiang University Department of Endocrinology the Second Affiliated Hospital School of Medicine Zhejiang University

Background and objective： Non-alcoholic fatty liver disease（NAFLD） is associated with arterial stiffness in the general population. Age, obesity, hypertension, and diabetics are risk factors for arterial stiffness. In this study, we aimed to investigate the association between NAFLD and arterial stiffness as measured by brachial-ankle pulse wave velocity（baPWV） in the non-obese, non-hypertensive, and non-diabetic young and middle-aged Chinese population. Methods： A cross-sectional study with 1296 non-obese, non-hypertensive, and non-diabetic young and middle-aged（20–65 years） subjects undergoing routine medical check-ups in the International Health Care Center of the Second Affiliated Hospital of School of Medicine of Zhejiang University was carried out. Fatty liver was diagnosed by ultrasonography, and baPWV was measured using an automatic waveform analyzer. The subjects were classified into two groups according to the presence of NAFLD, and divided into a further two groups according to their baPWV. Results： The overall incidence of NAFLD was 19.0%, and NAFLD patients had a significantly higher level of baPWV than the controls（（1321±158） cm/s vs.（1244±154） cm/s; P〈0.001）. The incidence of NAFLD was clearly higher in the increased baPWV group than in the normal baPWV group（29.3% vs. 16.9%; P〈0.001）, and the incidence increased in line with the increase of baPWV quartiles in the normal range as well as with the severity of arterial stiffness（both P for trend 〈0.001）. Multiple linear logistic regression analysis showed that the presence of NAFLD was positively and independently associated with baPWV. Conclusions： Our results suggest that the presence of NAFLD is associated with arterial stiffness as measured by baPWV in the non-obese, non-hypertensive, and non-diabetic young and middle-aged Chinese population.

关键词： Non-alcoholic fatty liver disease arterial stiffness Brachial-ankle pulse wave velocity Risk factor

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Reference values of carotid intima-media thickness and arterial stiffness in Chinese adults based on ultrasound radio frequency signal:A nationwide,multicenter study

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Chinese Medical Journal 2024年第15期137卷 1802-1810页

作者： Changyang Xing Xiujing Xie Yu Wu Lei Xu Xiangping Guan Fan Li Xiaojun Zhan Hengli Yang Jinsong Li Qi Zhou Yuming Mu Qing Zhou Yunchuan Ding Yingli Wang Xiangzhu Wang Yu Zheng Xiaofeng Sun Hua Li Chaoxue Zhang Cheng Zhao Shaodong Qiu Guozhen Yan Hong Yang Yinjuan Mao Weiwei Zhan Chunyan Ma Ying Gu Wu Chen Mingxing Xie Tianan Jiang Lijun Yuan Department of Ultrasound Medicine Tangdu HospitalAir Force Medical UniversityXi’anShaanxi 710038China Department of Ultrasound Medicine The First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310003China Department of Ultrasound Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Ultrasound Xi’an Hospital of Traditional Chinese MedicineXi’anShaanxi 710021China Ultrasound Medical Diagnosis Center Shaanxi Provincial People’s HospitalXi’anShaanxi 710068China Department of Ultrasound Hospital of Northwestern Polytechnical UniversityXi’anShaanxi 710072China Department of Ultrasound Xi’an No.1 HospitalThe First Affiliated Hospital of Northwest UniversityXi’anShaanxi 710002China Department of Ultrasound Diagnosis The Second Affiliated HospitalXi’an Medical CollegeXi’anShaanxi 710038China Department of Ultrasound Xi’an Gem Flower ChangQing HospitalXi’anShaanxi 710201China Department of Ultrasound The Second Affiliated Hospital of Xi’an Jiaotong UniversityChinaXi’anShaanxi 710004China Department of Echocardiography First Affiliated Hospital of Xinjiang Medical UniversityUrumqiXinjiang 830011China Department of Ultrasound Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Department of Ultrasound Yan’an HospitalThe Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650051China Department of Ultrasound Yan’an University Xianyang HospitalXianyangShaanxi 712000China Department of Function Examination Beijing University of Chinese Medicine Third Affiliated HospitalBeijing 100029China Department of Ultrasound Xi’an Central HospitalXi’anShaanxi 710004China Cadre’s Wards Ultrasound Department Diagnostic Ultrasound CenterFirst Hospital of Jilin UniversityChangchunJilin 130000China Department of Echocardiography Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical UniversityUrumqiXinjiang 830002China Department of Ultrasound First Affiliated

Background:Carotid intima-media thickness(IMT)and diameter,stiffness,and wave reflections,are independent and important clinical biomarkers and risk predictors for cardiovascular *** purpose of the present study was to establish nationwide reference values of carotid properties for healthy Chinese adults and to explore potential clinical ***:A total of 3053 healthy Han Chinese adults(1922 women)aged 18-79 years were enrolled at 28 collaborating tertiary centers throughout China between April 2021 and July *** real-time tracking of common carotid artery walls was achieved by the radio frequency(RF)ultrasound *** IMT,diameter,compliance coefficient,βstiffness,local pulse wave velocity(PWV),local systolic blood pressure,augmented pressure(AP),and augmentation index(AIx)were then automatically measured and *** were stratified by age groups and *** relationships between age and carotid property parameters were analyzed by Jonckheere-Terpstra test and simple linear *** major clinical determinants of carotid properties were identified by Pearson’s correlation,multiple linear regression,and analyses of ***:All the parameters of carotid properties demonstrated significantly age-related *** showed thinner IMT,smaller carotid diameter,larger AP,and AIx than ***βstiffness and PWV were significantly higher in men than women before forties,but the differences reversed after *** increase rate of carotid IMT(5.5µm/year in women and 5.8µm/year in men)and diameter(0.03 mm/year in both men and women)were similar between men and *** the stiffness and wave reflections,women showed significantly larger age-related variations than men as demonstrated by steeper regression slopes(all P for age by sex interaction<0.05).The blood pressures,body mass index(BMI),and triglyceride levels were identified as major clinical determinants of carotid properties with adjustment of age and ***

关键词： Intima-media thickness arterial stiffness Reference values Ultrasound radio frequency signal Wave reflections

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