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Pharmacokinetic comparison between ultraselection of uterine artery and peripheral vein chemotherapy of carboplatin in cervical cancer

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The Chinese-German Journal of Clinical Oncology 2009年第5期8卷 251-254页

作者： Wei Wang Chunlin Chen Ping Liu Ben Ma Cui Liu Lani Chen Department of Obsterics and Gynaecology Nanfang Hospital Southern Medical University Guangzhou 510515 China Department of Obsterics and Gynaecology The First People＇s Hospital of Guangzhou GuangZhou 510180 China Department of Obsterics and Gynaecology The Red Cross Society Hospital of Yulin Yunlin 537000 China Department of Obsterics and Gynaecology The First People＇s Hospital of Shunde Foshan 528225 China

Objective:The present study is to compare pharmacokinetics difference of carboplatin by using ultraselection uterine artery with by using peripheral vein in cervical ***:Thirteen patients with locally advanced cervical cancer who had been proved by pathobiology were randomly divided into two groups:the ultraselection uterine artery group(group A, n = 6) and the peripheral vein(group B, n = 7).Carboplatin was administered by infusing into artery or vein in both groups at the dosage of 300 mg/*** from the cervical tumor were collected at different times after infusion in both groups and then ***:The peak concentration of platinum in tumor tissue was about 2.79 times higher in group A than that of group B(P concentrations in tumor in group A reached its peak levels immediately after ***, group B had delayed ***, for the time point of 0 min, when the administration finished immediately, the platinum concentration in tumor was significantly higher when compared with group B(P area under the concentration(AUC) of carboplatin was about 2 times higher in group A than that of group B(P < 0.05).Conclusion:We observed the pharmacological advantages of chemotherapy by using ultraselection uterine artery administration of chemotherapeutic agent carboplatin in tumor tissue which provided theoretical basis and laboratory parameters of the intra-arterial chemotherapy for gynecologic malignancy.

关键词： cervical cancer uterine artery vein intra-arterial infusion chemotherapy peak value of platinum area underthe concentration time curve

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