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Differential expression of hepatic apurinic/apyrimidinic endonuclease 1,a DNA repair enzyme,in chronic hepatitis

World Journal of Hepatology 2013年第4期5卷 206-213页

作者： Shinichi Sumiyoshi Yoshimasa Kobayashi Kinya Kawamura Kazuhito Kawata Hirotoshi Nakamura Second Division Department of Internal MedicineHamamatsu University School of MedicineShizuoka 431-3192Japan

AIM:To determine hepatic expression of apurinic/apyrimidinic endonuclease 1(APE-1)and 8-hydroxydeoxyguanosine(8-OHdG)in patients with chronic hepatitis B and ***:Liver biopsies were obtained from 27 patients with chronic hepatitis B virus(HBV),30 with chronic hepatitis C virus(HCV),6 with autoimmune hepatitis(AIH),and 6 with primary biliary cirrhosis(PBC).Normal liver tissue was obtained from surgical resection specimens of four *** APE-1 protein and mRNA expression were assayed by Western blot and by real-time polymerase chain reaction,*** APE-1 and 8-OHdG expression were determined by ***:The staining intensity of hepatocellular nuclear APE-1 was lower in the HBV group than in the other groups(P < 0.05).Hepatic APE-1 protein levels were reduced in the HBV group relative to the other *** APE-1 mRNA levels were also lower in the HBV *** proportion of hepatocytes with 8-OHdG-positive nuclei was increased in the HCV,AIH and PBC groups(P < 0.05),but not in the HBV *** nuclear APE-1 levels were positively correlated with hepatocellular 8-OHdG levels in both the HBV and HCV groups(HBV,r = 0.34,P < 0.05;HCV,r = 0.54,P < 0.01).CONCLUSION:An imbalance between oxidative DNA damage and APE-1 expression may contribute to hepatocarcinogenesis in chronic viral hepatitis.

关键词： apurinic/apyrimidinic endonuclease 1 8-hydroxydeoxyguanosine Oxidative stress Viral hepatitis

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Enhancing expression of APEX gene by IL-2 in mouse T cells

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Chinese Science Bulletin 1996年第22期41卷 1912-1915页

作者：鲁林荣孙兰英刘新垣 Jacque Theze Shanghai Institute of Biochemistry Chinese Academy of Sciences Shanghai 200031 China Pasteur Institut Paris

Differentiation and proliferation of T lymphocytes are complicated processes,Which areregulated by various extracellular factors including antigens,growth factors and cell ***-2 is an important *** interaction between IL-2 and its receptormediates the cascade signal pathways and induces cellular proliferation and *** these processes,besides stimulating gene expressions of some common trans-criptional factor(such as c-FOS,c-JUN and c-MYC),IL-2 can induce specific genes inthe manner of cell type *** of special genes induced by

关键词： interleukin-2 (IL-2) differential display PCR (DDFCR) apurinic/apyrimidinic endonuclease (APEX) apoptosis.

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