检索结果-南通市图书馆

apparent diffusion coefficient by diffusion-weighted magnetic resonance imaging as a sole biomarker for staging and prognosis of gastric cancer

引用

Chinese Journal of Cancer Research 2017年第2期29卷 118-126页

作者： Francesco Giganti Alessandro Ambrosi Damiano Chiari Elena Orsenigo Antonio Esposito Elena Mazza Luca Albarello Carlo Staudacher Alessandro Del Maschio Francesco De Cobelli Department of Radiology and Experimental Imaging Center San Raffaele Scientific Institute Milan Italy Vita-Salute San Raffaele University Milan Italy Department of Surgery San Raffaele Scientific Institute Milan Italy Department of Oncology San Raffaele Scientific Institute Milan Italy Pathology Unit San Raffaele Scientific Institute Milan Italy

Objective： To investigate the role of apparent diffusion coefficient （ADC） from diffusion-weighted magnetic resonance imaging （DW-MRI） when applied to the 7th TNM classification in the staging and prognosis of gastric cancer （GC）. Methods： Between October 2009 and May 2014, a total of 89 patients with non-metastatic, biopsy proven GC underwent 1.5T DW-MRI, and then treated with radical surgery. Tumor ADC was measured retrospectively and compared with final histology following the 7th TNM staging （local invasion, nodal involvement and according to the different groups -- stage Ⅰ, Ⅱ and Ⅲ）. Kaplan-Meier curves were also generated. The follow-up period is updated to May 2016. Results： Median follow-up period was 33 months and 45/89 （51%） deaths from GC were observed. ADC was significantly different both for local invasion and nodal involvement （P〈0.001）. Considering final histology as the reference standard, a preoperative ADC cut-offof 1.80×10-3 mm^2/s could distinguish between stages I and Ⅱ and an ADC value of ≤1.36-10-3 mm^2/s was associated with stage Ⅲ（P〈0.001）. Kaplan-Meier curves demonstrated that the survival rates for the three prognostic groups were significantly different according to final histology and ADC cut-offs （P〈0.001）. Conclusions： ADC is different according to local invasion, nodal involvement and the 7th TNM stage groups for GC, representing a potential, additional prognostic biomarker. The addition of DW-MRI could aid in the staging and risk stratification of GC.

关键词： apparent diffusion coefficient diffusion-weighted magnetic resonance imaging gastric cancer prognosis TNM staging

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

apparent diffusion coefficient evaluation for secondary changes in the cerebellum of rats after middle cerebral artery occlusion

引用

Neural Regeneration Research 2013年第31期8卷 2942-2950页

作者： Yunjun Yang Lingyun Gao Jun Fu Jun Zhang Yuxin Li Bo Yin Weijian Chen Daoying Geng Department of Radiology Huashan Hospital Fudan University Department of Radiology First Affiliated Hospital of Wenzhou Medical University

Supratentorial cerebral infarction can cause functional inhibition of remote regions such as the cerebellum, which may be relevant to diaschisis. This phenomenon is often analyzed using positron emission tomography and single photon emission CT. However, these methods are expensive and radioactive. Thus, the present study quantified the changes of infarction core and remote regions after unilateral middle cerebral artery occlusion using apparent diffusion coefficient values. Diffu- sion-weighted imaging showed that the area of infarction core gradually increased to involve the cerebral cortex with increasing infarction time. diffusion weighted imaging signals were initially in- creased and then stabilized by 24 hours. With increasing infarction time, the apparent diffusion co- efficient value in the infarction core and remote bilateral cerebellum both gradually decreased, and then slightly increased 3-24 hours after infarction. apparent diffusion coefficient values at remote regions （cerebellum） varied along with the change of supratentorial infarction core, suggesting that the phenomenon of diaschisis existed at the remote regions. Thus, apparent diffusion coefficient values and diffusion weighted imaging can be used to detect early diaschisis.

关键词： neural regeneration brain injury cerebral ischemia cerebral infarction magnetic resonanceimaging apparent diffusion coefficient middle cerebral artery occlusion diffusion weighted imaging infarction core remote regions diaschisis grants-supported paper neuroregeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Correlation of magnetic resonance imaging quantitative parameters and apparent diffusion coefficient value with pathological breast cancer

引用

World Journal of Clinical Cases 2022年第21期10卷 7333-7340页

作者： Zhe Wang Guan-Ying Ren Qian Yin Qian Wang Department of Medical Imaging The No.2 Hospital of BaodingBaoding 071051Hebei ProvinceChina Department of Medical Oncology Affiliated Hospital of Hebei UniversityHebei Key Laboratory of Cancer Radiotherapy and ChemotherapyBaoding 071000Hebei ProvinceChina

BACKGROUND China ranks 120th worldwide for the incidence of breast cancer and 163rd for *** screening,diagnosis,and timely determination of the optimal treatment plan can help ensure clinical efficacy and *** To investigate the relationship between quantitative magnetic resonance imaging parameters,apparent diffusion coefficient value,pathological immunohistochemical status,and patient *** A total of 108 patients with breast cancer(breast cancer group)and 110 patients with benign breast tumors(benign group)confirmed by pathological examination at our Hospital from September 2013 to August 2016 were *** patients had undergone preoperative magnetic resonance imaging(MRI)examinations,and the quantitative parameters of MRI and apparent diffusion coefficient(ADC)values for the two groups were *** MRI quantitative parameters and ADC values of patients with different estrogen receptor(ER),progesterone receptor,and human epidermal growth factor receptor-2 expression were statistically *** relationship between the quantitative parameters of MRI and ADC values and patient recurrence was analyzed using receiver operating *** The measured values of the quantitative parameters of MRI-Ktrans,Kep,and Ve in the breast cancer group were higher than those in the benign group;the ADC value in the breast cancer group was lower than that in the benign group,and the difference was statistically significant(P<0.05).The Ktrans,Ve,and ADC values in patients with ER-positive breast cancer were significantly lower than those in patients with negative ER expression(P<0.05).After 5 years of follow-up,22 patients with breast cancer experienced postoperative *** Kep,Ve,and ADC values of the recurrence group were significantly lower than those of the non-recurrence group,and the difference was statistically significant(P<0.05).CONCLUSION MRI quantitative parameters and ADC are related to the expression of breast c

关键词： Magnetic resonance apparent diffusion coefficient Breast cancer Immunohistochemistry Prognosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Whole lesion histogram analysis of apparent diffusion coefficient predicts therapy response in locally advanced rectal cancer

引用

World Journal of Gastroenterology 2022年第23期28卷 2609-2624页

作者： Mayra Evelia Jiménez de los Santos Juan Armando Reyes-Pérez Victor Domínguez Osorio Yolanda Villaseñor-Navarro Liliana Moreno-Astudillo Itzel Vela-Sarmiento Isabel Sollozo-Dupont Department of Radiology National Cancer InstituteMexico 14080Mexico Department of Gastrointestinal Surgery National Cancer InstituteMexico 14080Mexico

BACKGROUND Whole-tumor apparent diffusion coefficient(ADC)histogram analysis is relevant to predicting the neoadjuvant chemoradiation therapy(nCRT)response in patients with locally advanced rectal cancer(LARC).AIM To evaluate the performance of ADC histogram-derived parameters for predicting the outcomes of patients with *** This is a single-center,retrospective study,which included 48 patients with *** patients underwent a pre-treatment magnetic resonance imaging(MRI)scan for primary tumor staging and a second restaging MRI for response *** sample was distributed as follows:18 responder patients(R)and 30 non-responders(non-R).Eight parameters derived from the whole-lesion histogram analysis(ADCmean,skewness,kurtosis,and ADC10^(th),25^(th),50^(th),75^(th),90^(th) percentiles),as well as the ADCmean from the hot spot region of interest(ROI),were calculated for each patient before and after *** all data were compared between R and non-R using the Mann-Whitney U *** measures of diagnostic accuracy were applied:the receiver operating characteristic curve and the diagnostic odds ratio(DOR).We also reported intra-and interobserver variability by calculating the intraclass correlation coefficient(ICC).RESULTS Post-nCRT kurtosis,as well as post-nCRT skewness,were significantly lower in R than in non-R(both P<0.001,respectively).We also found that,after treatment,R had a larger loss of both kurtosis and skewness than non-R(Δ%kurtosis and Δ skewness,P<0.001).Other parameters that demonstrated changes between groups were post-nCRT ADC10^(th),Δ%ADC10^(th),Δ%ADCmean,and ROIΔ%***,the best diagnostic performance was achieved byΔ%kurtosis at a threshold of 11.85%(Area under the receiver operating characteristic curve[AUC]=0.991,DOR=376),followed by post-nCRT kurtosis=0.78×10^(-3)mm^(2)/s(AUC=0.985,DOR=375.3),Δskewness=0.16(AUC=0.885,DOR=192.2)and post-nCRT skewness=1.59×10^(-3)mm^(2)/s(AUC=0.815,DOR=168.6).Finally,intraclass corr

关键词： apparent diffusion coefficient diffusion-weighted imaging Histogram analysis Magnetic resonance imaging Locally advanced rectal cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Textural differences based on apparent diffusion coefficient maps for discriminating pT3 subclasses of rectal adenocarcinoma

引用

World Journal of Clinical Cases 2021年第24期9卷 6987-6998页

作者： Zhi-Hua Lu Kai-Jian Xia Heng Jiang Jian-Long Jiang Mei Wu Department of Radiology Changshu Hospital Affiliated to Soochow UniversityChangshu No.1 People's HospitalChangshu 215500Jiangsu ProvinceChina Department of Information Changshu Hospital Affiliated to Soochow UniversityChangshu No.1 People's HospitalChangshu 215500Jiangsu ProvinceChina Department of Surgery Changshu Hospital Affiliated to Soochow UniversityChangshu No.1 People's HospitalChangshu 215500Jiangsu ProvinceChina Department of Pathology Changshu Hospital Affiliated to Soochow UniversityChangshu No.1 People's HospitalChangshu 215500Jiangsu ProvinceChina

BACKGROUND The accuracy of discriminating pT3a from pT3b-c rectal cancer using highresolution magnetic resonance imaging(MRI)remains unsatisfactory,although texture analysis(TA)could improve such *** To investigate the value of TA on apparent diffusion coefficient(ADC)maps in differentiating pT3a rectal adenocarcinomas from pT3b-c *** This was a case-control study of 59 patients with pT3 rectal adenocarcinoma,who underwent diffusion-weighted imaging(DWI)between October 2016 and December *** inclusion criteria were:(1)Proven pT3 rectal adenocarcinoma;(2)Primary MRI including high-resolution T2-weighted image(T2WI)and DWI;and(3)Availability of pathological reports for surgical *** exclusion criteria were:(1)Poor image quality;(2)Preoperative chemoradiation therapy;and(3)A different pathological ***-order(ADC values,skewness,kurtosis,and uniformity)and second-order(energy,entropy,inertia,and correlation)texture features were derived from whole-lesion ADC *** operating characteristic curves were used to determine the diagnostic value for pT3b-c *** The final study population consisted of 59 patients(34 men and 25 women),with a median age of 66 years(range,41-85 years).Thirty patients had pT3a,24 had pT3b,and five had *** the ADC first-order textural differences between pT3a and pT3b-c rectal adenocarcinomas,only skewness was significantly lower in the pT3a tumors than in pT3b-c *** the ADC second-order textural differences,energy and entropy were significantly different between pT3a and pT3b-c rectal *** differentiating pT3a rectal adenocarcinomas from pT3b-c tumors,the areas under the curves(AUCs)of skewness,energy,and entropy were 0.686,0.657,and 0.747,*** regression analysis of all three features yielded a greater AUC(0.775)in differentiating pT3a rectal adenocarcinomas from pT3b-c tumors(69.0%sensitivity and 83.3%specificity).CONCLUSION TA features

关键词： diffusion-weighted imaging apparent diffusion coefficient Rectal cancer Cancer stage Texture analysis case-control study

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

apparent diffusion coefficient in normal and abnormal pattern of intervertebral lumbar discs: initial experience

引用

The Journal of Biomedical Research 2011年第3期25卷 197-203页

作者： Gang Niu Xuewen Yu Jian Yang Rong Wang Shaojuan Zhang Youmin Guo Department of Diagnostic Radiology the First Hospital of Medical School Xi'an Jiaotong University Xi'an Shaanxi 710061 China

The aim of the present study was to compare the relationship of morphologically defined non-bulging/herni-ated, bulging and herniated intervertebral lumbar discs with quantitative apparent diffusion coefficient （ADC）. Thirty-two healthy volunteers and 28 patients with back pain or sciatica were examined by MRI. All intervertebral lumbar discs from L1 to S1 were classified according to morphological abnormality and degenerated grades. The ADC values of nucleus pulposus （NP） were measured and recorded. The significant differences about mean ADC values of NP were found between non-bulging/herniated discs and bulging discs as well as herniated discs （P 0.05）, whereas there were no significant differences in ADC values between bulging and herniated discs （P 0.05）. Moreover, statistically significant relationship was found in the mean ADC values of NP between ＂non-bulging/herniated and non-degenerated discs＂ and ＂non-bulging/herniated degenerated discs＂ as well as herniated discs （P 0.05）. Linear regression analysis between ADC value and disc level revealed an inverse correlation （r = -0.18）. The ADC map of the NP is a potentially useful tool for the quantitative assessment of componential and molecular alterations accompanied with lumbar disc abnormalities.

关键词： intervertebral lumbar disc apparent diffusion coefficient disc bulging disc herniation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The apparent diffusion coefficient does not reflect cytotoxic edema on the uninjured side after traumatic brain injury

引用

Neural Regeneration Research 2014年第9期9卷 973-977页

作者： Hong Lu Xiaoyan Lei Department of Radiology Affiliated Haikou Hospital Xiangya School of Medicine Central South University

After traumatic brain injury, vasogenic and cytotoxic edema appear sequentially on the involved side. Neuroimaging investigations of edema on the injured side have employed apparent diffusion coefficient measurements in diffusion tensor imaging. We investigated the changes occurring on the injured and uninjured sides using diffusion tensor imaging/apparent diffusion coefficient and histological samples in rats. We found that, on the injured side, that vasogenic edema appeared at 1 hour and intracellular edema appeared at 3 hours. Mixed edema was observed at 6 hours, worsening until 12–24 hours post-injury. Simultaneously, microglial cells proliferated at the trauma site. apparent diffusion coefficient values increased at 1 hour, decreased at 6 hours, and increased at 12 hours. The uninjured side showed no significant pathological change at 1 hour after injury. Cytotoxic edema appeared at 3 hours, and vasogenic edema was visible at 6 hours. Cytotoxic edema persisted, but vasogenic edema tended to decrease after 12–24 hours. Despite this complex edema pattern on the uninjured side with associated pathologic changes, no significant change in apparent diffusion coefficient values was detected over the first 24 hours. apparent diffusion coefficient values accurately detected the changes on the injured side, but did not detect the changes on the uninjured side, giving a false-negative result.

关键词： nerve regeneration brain injuries blood-brain barrier magnetic resonance imaging apparent diffusion coefficient intracranial edema cytotoxic edema vasogenic edema pathology NSFC grant neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Early changes in apparent diffusion coefficient as an indicator of response to sorafenib in hepatocellular carcinoma

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2014年第8期15卷 713-719页

作者： Yi-lei ZHAO Qing-qu GUO Gen-ren YANG Qi-dong WANG Department of Radiology the First Affiliated Hospital School of Medicine Zhejiang University Department of Surgery the Second Affiliated Hospital School of Medicine Zhejiang University

Objective： The relationship between apparent diffusion coefficient （ADC） and chemotherapy has been established. However, whether ADC could be considered as a measure for monitoring response to sorafenib in hepatocellular carcinoma （HCC） has not been demonstrated. This study was to investigate the ADC changes of ad- vanced HCC under sorafenib treatment. Methods： Athymic mice with HepG2 xenografts were allocated to two groups： control and sorafenib （40 mg/kg, bid）. T2 and diffusion images were acquired at each time point （0, 10, 14, and 18 d post-therapy）. Tumor volume and changes in ADC were calculated. Results： Tumor volumes on Days 10, 14, and 18 after treatment showed significant decreases in the sorafenib-treated group compared with the control. Pretreatment ADC values were not significantly different between the control and treated groups. A slow increase in ADC in the peripheral zone of tumors appeared in the treated group, which was significantly higher compared with the control group on Days 10, 14, and 18. In the central part of tumors on Day 10 after treatment, an increase in ADC appeared in the treated and control groups, the ADC of the control group being significantly lower compared with the treated tumors From Day 10 to Day 14, the ADC map showed a progressive decrease in the central region of tumors in the treated and control groups. However, this change is more significant in the treated groups. Conclusions： Early changes in mean ADC correlated with sorafenib treatment in HCC, which are promising indicators for predicting sorafenib response in this carcinoma.

关键词： Hepatocellular carcinoma Sorafenib apparent diffusion coefficient Magnetic resonance imaging (MRI)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Relative apparent diffusion coefficient： a promising tool to differentiate metastatic from benign lymph nodes in animal models

引用

Chinese Medical Journal 2011年第18期000卷 2907-2910页

作者： XING Wei SHENG Jing CHEN Jie TIAN Jian-ming BI Heng-liang Department of Radiology the Third Affiliated Hospital of SuzhouUniversity Changzhou Jiangsu 213003 China Department of Radiology Changhai Hospital the Second MilitaryMedical University Shanghai 200433 China

Background diffusion-weighted imaging has been widely used to differentiate the character of lymphadenopathy. But there are significant differences between prior studies. The aim of the study was to compare the benefit of apparent diffusion coefficient （ADC） and rADC in the differentiation of metastatic and benign lymph nodes in a rabbit model. Methods Two observers independently measured ADCs in quadriceps of every rabbit on diffusion-weighted images with different sizes of regions of interest （ROI）. The appropriate ROI for rADC was determined using the interobserver coefficient, rADC was calculated by AOClesion/AOCreference site- Receiver operating characteristics （ROC） analysis was performed to compare the diagnostic value of the ADC values and rADC values in differentiating metastatic from benign lymph nodes. Results When the ROIs included five pixels, the ICC was 0.816, indicating a good interobserver agreement. The differences of ADC and rADC values between metastatic and benign lymph nodes were both statistically significant. The area under the ROC curve was greater for the rADC than for the ADC. With the rADC criteria of 0.640, the sensitivity and specificity for differentiating metastatic from benign lymph nodes were 93% and 90%, respectively. Conclusion As a reference site, muscles reveal a good repeatability using a small ROI and the rADC may improve diagnostic accuracy for detecting metastatic nodes in animal models.

关键词： diffusion-weighted imaging magnetic resonance imaging apparent diffusion coefficient relative ADC lymph nodes VX2

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Coronal diffusion-weighted Magnetic Resonance Imaging of the Kidney： Agreement with Axial diffusion-weighted Magnetic Imaging in Terms of apparent diffusion coefficient Values

引用

Chinese Medical Journal 2015年第4期128卷 499-503页

作者： Hai-Yi Wang Jia Wang Ye-Huan Tang Hui-Yi Ye Lin Ma Department of Radiology Chinese People@s Liberation Army General Hospital Beijing 100853 China Department of Radiology Handan Central Hospital Handan Hebei 056001 China

Background：Coronal diffusion-weighted magnetic resonance imaging （DW-MRI） and apparent diffusion coefficient （ADC） values have gradually become applied （following conventional axial DW-MRI） in the renal *** explore whether data obtained using coronal DW-MRI are comparable with those derived using axial DW-MRI,this preliminary study sought to assess the agreement in renal ADC values between coronal DW-MRI and axial ***：Thirty-four healthy volunteers were enrolled in the study; written consents were *** subjects underwent respiratory-triggered axial and coronal DW-MRI using a 1.5-MR system with b values of 0 and 800 s/*** signal-to-noise ratios （SNRs） of the two DW-MRI sequences were measured and statistically compared using the paired *** extent of agreement of ADC values of the upper pole,mid-pole,and lower pole of the kidney; the mean ADC values of the left kidney and right kidney; and the mean ADC values of the bilateral kidneys were evaluated via calculation of intraclass correlation coefficients （ICCs） or Bland-Altman method between the two DW-MRI ***：The SNR of coronal DW-MR images was statistically inferior to that of axial DW-MR images （P ＜ 0.001）.The ICCs of the ADC values of each region of interest,and the mean ADC values of bilateral kidneys,between the two sequences,were greater than 0.5,and the mean ADCs of the bilateral kidneys demonstrated the highest ICC （0.869; 95％ confidence interval：0.739-0.935）.In addition,94.1％（32/34）,94.1％（32/34）,and 97.1％（31/34） of the ADC bias was inside the limits of agreement in terms of the mean ADC values of the left kidneys,right kidneys,and bilateral kidneys when coronal and axial DWI-MRI were ***：ADC values derived using coronal DW-MRI exhibited moderate-to-good agreement to those of axial DW-MRI,rendering the former an additional useful DW-MRI method,and causing the ADC values derived using the two types of DW-MRI to be comparable.

关键词： apparent diffusion coefficient diffusion-weighted Magnetic Resonance Imaging Humans Kidney Magnetic Resonance Imaging

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：