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Numerical Simulation of Blood Flow in Aorta with dilation:A Comparison between Laminar and LES Modeling Methods

Computer Modeling in Engineering & Sciences 2020年第8期124卷 509-526页

作者： Lijian Xu Tianyang Yang Lekang Yin Ye Kong Yuri Vassilevski Fuyou Liang School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China Shanghai Chest Hospital Shanghai Jiao Tong UniversityShanghai200030China Zhongshan Hospital Fudan UniversityShanghai200032China Marchuk Institute of Numerical Mathematics Russian Academy of SciencesMoscow119333Russia Institute for Personalized Medicine Sechenov UniversityMoscow119991Russia Key Laboratory of Hydrodynamics(Ministry of Education) Shanghai Jiao Tong UniversityShanghai200240China

Computational modeling methods have been increasingly employed to quantify aortic hemodynamic parameters that are challenging to in vivo measurements but important for the diagnosis/treatment of aortic *** the presence of turbulence-like behaviors of blood flow in normal or diseased aorta has long been confirmed,the majority of existing computational model studies adopted the laminar flow assumption(LFA)in the treatment of sub-grid flow *** far,it remains unclear whether LFA would significantly compromise the reliability of hemodynamic *** the present study,we addressed the issue in the context of a specific aortopathy,namely aortic dilation,which is usually accompanied by disturbed flow *** patient-specific aortas with treated/untreated dilation of the ascending segment were investigated,and their geometrical models were reconstructed from computed tomography angiographic images,with the boundary conditions being prescribed based on flow velocity information measured in vivo with the phase contrast magnetic resonance imaging *** the modeling of blood flow,apart from the traditional LFA-based method in which sub-grid flow dynamics is ignored,the large eddy simulation(LES)method capable of incorporating the dissipative energy loss induced by turbulent eddies at the sub-grid level,was adopted and taken as a reference for examining the performance of the LFA-based *** results showed that the simulated large-scale flow patterns with the two methods had high similarity,both agreeing well with in vivo measurements,although locally large between-method discrepancies in computed hemodynamic quantities existed in regions with high intensity of flow ***,a switch from the LES to the LFAbased modeling method led to mild(aortic segment where intensive vortex evolution accompanied by high stat

关键词： Blood flow aortic dilation computational modeling turbulence laminar flow assumption large eddy simulation

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Retrospective analysis of the prognostic effect of angiotensin receptor blocker on non-Marfan aortic dissection

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South China Journal of Cardiology 2020年第3期21卷 163-167,197页

作者： HUANG Cheng LIN Yu-peng JIANG Zhi-sheng HUANG Wen-hui Department of Cardiology Guangdong Cardiovascular institute.Provincial Key Laboratory of Coronary Heart Disease PreventionGuangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510080GuangdongChina Jieyang People's Hospital Jieyang 522000GuangdongChina Institute of Cardiovascular Disease and Key Laboratory for Arteriosclerology of Hunan Province Hengyang Medical SchoolUniversity of South ChinaHengyang 421000HunanChina

Background aortic dissection(AD)is a life-threatening vascular disease caused by various etiologies including Marfan’s *** receptor blocker(ARB)drugs have been confirmed beneficial for patients with Marfanoid AD but remain unclear for non-Marfanoid *** Patients with DeBakey typeⅢ,Standford A aortic dissection were consecutively recruited to Guangdong Provincial People’s Hospital and Jieyang People’s Hospital between January 2010 and January 2015,with 25 individuals in the ARB group and 32 individuals in the non-ARB group(control group),*** follow-up was performed by database or *** follow-up data consisted of patient’s symptoms and chief complaints,blood pressure,heart rate,and aortic computed tomography angiography(CTA)*** and in-hospital events were *** Baseline data,including age,gender,heart rate,smoking status,and the incidence of diabetes,demonstrated no significant difference between two *** was neither death nor urgent surgical case in either group during the follow-up *** aortic CTA follow-up demonstrated the absorption of the proximal inversely avulsed hematoma for both groups,whereas the reduction was more evident in the ARB group as compared with the non-ARB group[-(9.33±1.99)mm vs.-(4.08±2.35)mm,respectively,Paortic enlargement and *** Independent of blood pressure(BP)reduction,ARB utilization in patients with non-Marfan’s aortic dissection may facilitate the absorption of reverse-torn hematoma at the proximal end of dissection,as well as delaying the aortic dilatio

关键词： angiotensin receptor blocker non-Marfanoid aortic dissection aortic dilation proximal laceration hematoma

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