检索结果-南通市图书馆

中国实验血液学杂志 1997年第3期5卷 294-294页

作者： Wenhong Fan, Yinglin Lu, P. H. Tang, Xueming Ge, Shuang LiuDepartment of Molecular Pathology, Institute of Basic Medical Sciences, Beijing 100850

Objective: Overexpression of the membraneepidermal growth factor receptor (EGFR) in humantumor cells predicts for poor prognosis. Hence, weexperimentally investigated the effects of humanEGFR to the malignant phenotyp... 详细信息

关键词： phenotype antisense RNA prognosis partially blocks nude inhibited targeted lipofectamine

Experimental gene therapy for brain tumors using antisense or triple helix approaches

在线全文

学校读者我要写书评

暂无评论

中国实验血液学杂志 1997年第3期5卷 287-287页

作者： J.Trojan H.T.Duc L.C.UpeguiGonzalez B.Swiercz F.Hor D.D.Anthony I.Royston Hepato-Biliary Center Paul Brousse HospitalVillejuifFrance Department of Pharmacology Case Western Reserve University School of MedicineCleveland and Sidney Kimmel Cancer CenterCalifornia.USA

The insulin-like growth factor l (IGF-1) iscommonly expressed in most of tumor cells and plays arole in the growth and development of animal andhuman tumors. Tumor cells transfected with a vectorencoding antisense IGF... 详细信息

关键词： triple antisense helix neuroblastoma hepatoma glioma suppression manner antitumor inhibit

Transduction of antisense RNA of MHC-Ⅱ gene into CD34 cord blood stem/progenitor cells inhibits the expression of HLA-DR antigen

在线全文

学校读者我要写书评

暂无评论

中国实验血液学杂志 1997年第3期5卷 323-323页

作者： Yu-Bin Deng, Shu-Nong Li, Shao-Liang Huang, Ren-Wei Huang, Qiang Xie Sun Yat-Sen Universitv of Medical Sciences, Guangzhou510089

Purpose: To explore whether the antisense RNA ofMHC-Ⅱ gene could inodulate the expression of HLA-DRgene and reduce the immunogenicity of cord blood (CB)cells.The authors transduced the antisense RNA ofMHC-Ⅱ gene into CD34 CB stem/progenitor cells.Methods: A retroviral vector encoding antisense RNA ofHLA-DR gene was constructed by molecular cloningtechnique and transducted into packaging cells line PA317by lipofectin. The high titer, helper-free,

关键词： progenitor antisense RNA helper encoding titer packaging prevention enriched stern

An in vitro study on inhibition of hepatitis B virus expression by antisense oligodeoxynucleotides directed at HBVX translation initiator

在线全文

学校读者我要写书评

暂无评论

中国输血杂志 2001年第S1期14卷 334-页

09070 antisense Pharma公司的临床试验

在线全文

学校读者我要写书评

暂无评论

国外药讯 2001年第9期 30-31页

作者：王会英

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

RESPIRATORY SYSTEM

China Medical Abstracts(Internal Medicine) 2001年第1期18卷 22-27页

Targeting Transforming Growth Factor-<i>β</i>(TGF-<i>β</i>) in Cancer and Non-Neoplastic Diseases

在线全文

学校读者我要写书评

暂无评论

Journal of Cancer Therapy 2014年第7期5卷 735-747页

作者： Michael Nacif Olfat Shaker Department of Biochemistry and Molecular Biology Faculty of Medicine Cairo University Giza Egypt Department of Molecular Diagnostics Genetic Engineering and Biotechnology Research Institute (GEBRI) Sadat City University Sadat City Egypt

Transforming growth factor-β?(TGF-β) superfamily is a key player in the regulation of a wide variety of physiological processes from development to pathogenesis. Since the discovery of the prototypic member, TGF-β, almost three decades ago, there have been tremendous advances in our understanding of its complex biology. TGF-β?misregulation has been implicated in the pathogenesis of a variety of diseases, including cancer with a direct role in facilitating metastasis, fibrosis and inflammation. Consequently, TGF-β?is currently explored as a prognostic candidate biomarker of tumor invasiveness and metastasis;and it offers an attractive target for cancer therapy. Several anti-TGF-β?approaches, such as TGF-β?antibodies, antisense oligonucleotides and small molecules inhibitors of TGF-β?type 1 receptor kinase, have shown great promise in the preclinical studies. Here, we consider why the TGF-βsignaling pathway is a drug target, the potential clinical applications of TGF-β?inhibition, the issues arising with anti-TGF-β?therapy and how these might be adopted using personalized approaches with a special care for patient selection and timing of therapy so that we may bring forward all the potentials of targeting this pathway for therapeutic uses in both cancer, preferentially in combination therapy, and non-neoplastic diseases.

关键词： Transforming Growth Factor-β (TGF-β) Monoclonal Antibodies (MoAbs) antisense Oligonucleotides (ASO) Small Molecule Receptor Kinase Inhibitors (SMIs)

LIVER AND BILIARY SYSTEM

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Medical Abstracts(Internal Medicine) 2000年第1期17卷 40-46页

在线全文

学校读者我要写书评

暂无评论

GENERAL SURGERY

外科研究与新技术 1995年第1期 2-14页

2.ITb界幼d,p”灿比加旧记gbLnd酬又目万I改垃沈canCer in rats andn云沈.indu叱比脚旧idFang昵itang(房维堂,et al.Inst Preve&TreatB劝曰ie Dis公团团以唱Jinan 250014 WIStar tatsa旧Iha口iCe wete fed withanar口al diet or a diet ... 详细信息

关键词： strie estrogen vival operative iodide neoplasm iodine gallbladder antisense possibility

在线全文

学校读者我要写书评

暂无评论

INFECTIOUS DISEASE

China Medical Abstracts(Internal Medicine) 1997年第3期14卷 134-139页