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Effectiveness of Traditional Chinese Medicine on coronavirus disease 2019 in 92 patients:a retrospective study

Journal of Traditional Chinese Medicine 2023年第3期43卷 582-587页

作者： XU Guihua CHEN Feifei ZHANG Wei WU Yingen CHEN Xiaorong SHI Kehua WANG Zhenwei SHI Miaoyan ZHANG Xing LU Yunfei YUAN Weian LYU Hua CHEN Xuan Shuguang Hospital Shanghai University of Traditional Chinese MedicineShanghai 201203China Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China Shanghai Public Health Clinical Center Fudan UniversityShanghai 201508China Shanghai Hospital of Traditional Chinese Medicine Shanghai 200071China Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai 200437China

OBJECTIVE:To investigate the antipyretic effect of early treatment with Traditional Chinese Medicine(TCM) on coronavirus disease 2019(COVID-19) patients.METHODS:We retrospectively analyzed 369 patients from January 26th,2020 to April 15th,2020,who had been diagnosed with COVID-19.Among 92 eligible cases,45 cases were identified as treatment group Ⅰ(n = 45) and 47 cases were identified as treatment group Ⅱ.Patients in the treatment group Ⅰ were treated with TCM herbal decoction within 5 d after admission.Patients in the treatment group Ⅱ were treated with TCM herbal decoction after the 6th admission day.The onset time of antipyretic effect,the antipyretic time,the time of negative oropharyngeal swab nucleic acid conversion,and the changes of cell count in blood routine test were compared.RESULTS:The treatment group Ⅰ showed shorter average antipyretic duration(4 vs 7 d;P 38 ℃,patients in the treatment group I had shorter median onset time of antipyretic effect than those in the treatment group Ⅱ(3 vs 4 d;P < 0.05).The absolute lymphocyte(LYMPH) count and absolute eosinophil(EOS) count on the 3rd day after admission and the neutrophil/lymphocyte ratio on the 6th day after admission of patients in the treatment group I were notably different from those in the treatment group Ⅱ at the same time point(P < 0.05).Based on Spearman’s rank correlation analysis,the change of body temperature on the 3rd day after admission was positively correlated with the increase of EOS count and the increase of EOS count and LYMPH counts on the 6th day after admission(P < 0.01).CONCLUSIONS:Early TCM intervention within 5 d after hospital admission shortened the onset time of antipyretic effect and fever duration of COVID-19 patients,reduced the time required for PCR test results to turn negative.Moreover,early TCM intervention also impr

关键词： COVID-19 medicine Chinese traditional antipyretics immune-inflammatory parameters retrospective studies

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In-vitro and in-vivo pharmacological screening of Iris albicans

引用

Journal of Traditional Chinese Medicine 2022年第1期42卷 9-16页

作者： Dawood Kamal Roohullah Fazle Rabbi Attiqa Naz Muhammad Bilal Department of Pharmacy Abasyn University PeshawarPeshawar25000Khyber PakhtunkhwaPakistan

OBJECTIVE:To evaluate the anti-oxidant,enzyme inhibition,anti-pyretic,anti-inflammatory and anti-diabetic activities of Iris albicans.METHODS:Anti-oxidant assay was evaluated using DPPH(2,2-diphenyl-1-picrylhydrazyl)radical scavenging and ABTS(2,2'-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid)inhibitory protocol while enzyme inhibitory assay was evaluated by lipoxygenase and cyclooxygenase-2 inhibitory protocol respectively.Antipyretic,anti-inflammatory and anti-diabetic potential was evaluated using brewer's yeast induced pyrexia,carrageenan induced paw edema and streptozocin induced diabetes protocols respectively.Serum biochemical parameters were monitored for the period of study.RESULTS:The anti-oxidant activity of chloroform fraction of Iris albicans showed the highest scavenging potential against DPPH and ABTS while the maximum inhibitory action recorded against lipo-oxygenase and cyclooxygenase-2 enzymes was shown by n-hexane and chloroform fractions respectively.The anti-pyretic potential of the crude methanolic extract showed dose dependent activity in reducing pyrexia,thereby when the dose was increased the anti-pyretic effect was also enhanced.The anti-inflammatory action of the crude methanolic extract administered at the dose of 300 mg/kg was significant at 1 h after its administration,which was found maintained up to 5 h.Similarly the anti-diabetic effect of the crude methanolic extract administered at the dose of 200 and 300 mg/kg was noted highly significant at day 6 and was found well maintained throughout the study time period up to 10 days.Significant(P<0.001)improvement appeared in hemoglobin,protein,cholesterol,triglycerides,urea,creatinine,HDL and LDL of extract treated diabetic mice.CONCLUSION:From this data it could be concluded that Iris albicans have significant anti-oxidant,enzyme inhibition,ant-pyretic,anti-inflammatory and anti-diabetic potential.

关键词： antioxidants anti-inflammatory agent antipyretics hypoglycemic agents Iris Albicans

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