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Effect of Dialysis on antiplatelet drug Efficacy in Uremic Patients with Coronary Heart Disease

Chinese Medical Journal 2017年第16期130卷 1914-1918页

作者： Dong-Liang Fu Ting-Ting Zhao Wen-Hua Peng Peng Yang Xiao-Fei Liu Hu Zhang Xian-Lun Li Yong Wang Jin-Gang Zheng Yan-Xiang Gao Hong-Kai Lu Qi Wang Department of Cardiology China-Japan Friendship Hospital Beijing 100029 China Department of Cardiology Peking University China-Japan Friendship School of Clinical Medicine Beijing 100029 China Department of Laboratory China-Japan Friendship Hospital Beijing 100029 China

Background： Coronary intervention therapy is the main treatment for uremic patients with coronary heart disease. The studies on whether dialysis reduces the efficacy of dual antiplatelet drugs are limited. The aim of this study was to examine the effect of dialysis on antiplatelet drugs in uremic patients with coronary heart disease. Methods： This study included 26 uremic patients who had undergone percutaneous coronary intervention in China-Japan Friendship Hospital from November 2015 to May 2017. We examined their thromboelastography results before and after hemodialysis. Self-paired t-tests were employed to analyze changes in the inhibition rate of platelet aggregation. Results： The mean inhibition rates of arachidonic acid-induced platelet aggregation before and after hemodialysis were 82.56 ± 2.79% and 86.42±3.32%, respectively （t =-1.278, P = 0.213）. The mean inhibition rates of adenosine diphosphate-induced platelet aggregation before and after hemodialysis were 67.87± 5.10% and 61.9± 5.90%, respectively （t = 1.425, P = 0.167）. There was no significant difference in the inhibition rates ofplatelet aggregation before or after hemodialysis. These results also applied to patients with different sensitivity to aspirin and clopidogrel. Conclusion： Dialysis did not affect the antiplatelet effects of aspirin and clopidogrel in uremic patients with coronary heart disease.

关键词： antiplatelet drug Coronary Intervention Dialysis Thromboelastography

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Characteristics of β-oxidative and reductive metabolism on the acyl side chain of cinnamic acid and its analogues in rats

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Acta Pharmacologica Sinica 2019年第8期40卷 1106-1118页

作者： Kai-jing Zhao Yang Chen Shi-jin Hong Yi-ting Yang Jiong Xu Han-yu Yang Liang Zhu Ming Liu Qiu-shi Xie Xian-ge Tang Ting-ting Yang Ya-qian Zhou Li Liu Xiao-dong Liu Center of drug Metabolism and Pharmacokinetics School of PharmacyChina Pharmaceutical University

Cinnamic acid and its analogues(pyragrel and ozagrel)undergo chain-shortened(β-oxidative)and reductive metabolism on acyl side *** this study,we characterized the β-oxidative and reductive metabolism on acyl side chain of cinnamic acid and its analogues using primary rat hepatocytes,hepatic mitochondrial,and microsomal systems.A compartmental model including parent compounds and metabolites was developed to characterize in vivo β-oxidative and reductive metabolism following an intravenous dose of parent compounds to *** fitted total in vivo clearance values were further compared with the in vitro values predicted by the well-stirred *** showed that hepatic microsomal CYP450s did not catalyze β-oxidative or reductive metabolism of the three *** to β-oxidation of fatty acids,β-oxidative metabolism on their acyl side chain occurred mainly in mitochondria,which was highly dependent on ATP,CoA and NAD~+.Fatty acids and NADH inhibited the β-oxidative *** metabolism occurred in both mitochondria and *** in mitochondria was ATP-,CoA-,and NAD(P)H-dependent and reversible,which was suppressed by enoyl reductase inhibitor *** in microsomes was ATP-,CoA-,and NADPH-dependent but little affected by *** plasma concentrations of β-oxidative metabolites and reductive metabolites were successfully fitted using the compartmental *** estimated total in vivo clearance values were consistent with those predicted from hepatocytes and organelles,implicating significance of in vitro *** findings demonstrate the roles of hepatic mitochondria and microsomes in β-oxidative and reductive metabolism on acyl side chain of cinnamic acid and its analogues along with their metabolic characteristics.

关键词： antiplatelet drug cinnamic acid pyragrel ozagrel drug metabolism hepatocytes mitochondria microsomes pharmacokinetics in vitro-in vivo correlation

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Latest Advancement of Non ST-segment Elevation Acute Coronary Syndrome

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South China Journal of Cardiology 2008年第4期9卷 203-208页

作者：黄桂锋杨希立 The First People's Hospital of Foshan

Further understanding of the pathphophisyology, advance of the diagnosis instrument and renovation of the risk delamination standard can offer better therapy evidence for the non-ST-segment elevation acute coronary syndrome(NSTE-ACS). drugs, such as trigeminy antiplatelet drug, prasugrel, fondaparinux and bivalirudin, have brought great clinical effect to the high risk patients. Since the result of the ICTUS test announced and the drug eluting balloon developed, we have reached the newest recognition of how to select a chance for intervention and how to prevent and cure the restenosis of in-stent.

关键词： non-ST-segment elevation acute coronary syndrome diagnosis risk classification antiplatelet drug percutaneous coronary intervention

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