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Bioplastic classifications and innovations in antibacterial,antifungal,and antioxidant applications

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Journal of Bioresources and Bioproducts 2023年第4期8卷 361-387页

作者： Sariah Abang Farrah Wong Rosalam Sarbatly Jamilah Sariau Rubiyah Baini Normah Awang Besar Department of Chemical Engineering and Energy Sustainability Faculty of EngineeringUniversiti Malaysia SarawakKota Samarahan 94300Malaysia Electronic Engineering(Computer)Programme Faculty of EngineeringUniversiti Malaysia SabahKota Kinabalu 88400Malaysia Chemical Engineering Programme Faculty of EngineeringUniversiti Malaysia SabahKota Kinabalu 88400Malaysia Forest Plantation and Agroforestry Programme Faculty of Tropical ForestryUniversiti Malaysia SabahKota Kinabalu 88400Malaysia

Conventional plastics exacerbate climate change by generating substantial amounts of greenhouse gases and solid wastes throughout their lifecycle.To address the environmental and economic challenges associated with petroleum-based plastics,bioplastics have emerged as a viable alternative.Bioplastics are a type of plastic that are either biobased,biodegradable,or both.Due to their biodegradability and renewability,bioplastics are established as earth-friendly materials that can replace nonrenewable plastics.However,early bioplastic development has been hindered by higher production costs and inferior mechanical and barrier properties compared to conventional plastics.Nevertheless,studies have shown that the addition of additives and fillers can enhance bioplastic properties.Recent advancements in bioplastics have incorporated special additives like antibacterial,antifungal,and antioxidant agents,offering added values and unique properties for specific applications in various sectors.For instance,integrating antibacterial additives into bioplastics enables the creation of active food packaging,extending the shelf-life of food by inhibiting spoilage-causing bacteria and microorganisms.Moreover,bioplastics with antioxidant additives can be applied in wound dressings,accelerating wound healing by preventing oxidative damage to cells and tissues.These innovative bioplastic developments offer promising opportunities for developing sustainable and practical solutions in various fields.Within this review are two main focuses:an outline of the bioplastic classifications to understand how they fit in as the coveted conventional plastics substitute and an overview of the recent bioplastic innovations in the antibacterial,antifungal,and antioxidant applications.We cover the use of different polymers and additives,presenting the findings and potential applications within the last decade.Although current research primarily focuses on food packaging and biomedicine,the exploration of bioplastics with specialized properties is st

关键词： Bioplastic Biopolymer Biodegradability Antibacterial antifungal Antioxidant

β-1,2-Mannan-based glycoconjugates as potential antifungal vaccines

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Chinese Chemical Letters 2022年第9期33卷 4345-4349页

作者： Jun Liao Bo Pan Xiaobin Zhuo Guochao Liao Yun Gao Zhenzhen Yao Lianghua Wang Qiuye Wu Weihua Pan Binghua Jiao Qingjie Zhao Department of Biochemistry and Molecular Biology College of Basic Medical SciencesSecond Military Medical UniversityShanghai 200433China School of Pharmacy Second Military Medical UniversityShanghai 200433China Department of Dermatology Changzheng HospitalSecond Military Medical UniversityShanghai 200003China International Institute for Translational Chinese Medicine Guangzhou University of Chinese MedicineGuangzhou 510006China

Phosphorylated di-,tri-and tetra-saccharides ofβ-1,2-mannan antigen derived from Candida albicans(C.albicans)cell wall were synthesized and covalently conjugated with keyhole limpet hemocyanin(KLH)and human serum albumin(HSA)via a bifunctional linker under mild conditions.The semi-syntheticβ-1,2-mannoside–KLH conjugates were evaluated for the immunization of BALB/c mice.The ELISA results revealed that all three conjugates could elicit high levels of specific IgG antibodies and the acquired antisera could effectively identify theβ-1,2-mannan epitope.Furthermore,the immunofluorescence and flow cytometry assays also uncovered that the induced antibodies,especially that obtained from immunization withβ-1,2-mannotriose–KLH conjugate(1b),could bind well to fungi cell.Eventually,the structure–immunogenicity relationship analysis ofβ-mannan showed that the length of oligo-β-mannoses had a big impact on their immunogenicity andβ-1,2-mannotriose showed the strongest immunogenicity.The results suggested the great potential ofβ-1,2-mannotriose–KLH conjugate as an antifungal vaccine candidate.

关键词： β-1,2-Mannan Oligosaccharide antifungal Glycoconjugate Vaccine Antigen

Chemical composition and antifungal potential of apricot,sour cherry,and cherry tree bio-products(resins)against food-borne molds

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Food Bioscience 2022年第3期47卷 240-244页

作者： Oktay Tomar Gökhan Akarca Veli Gök Ömer İstek Kocaeli University Faculty of AgricultureArslanbey Campus41285KocaeliTurkey Afyon Kocatepe University Faculty of EngineeringDepartment of Food Engineering03200AfyonkarahisarTurkey Ahmet İpek Meat Co Organized Industrial Zone1st StreetAfyonkarahisar03200Turkey

In this study,the chemical components of ethanol extracts from the resins of apricot(Prunus armeniaca L.),sour cherry(Prunus cerasus L.)and cherry(Prunus avium L.)trees were investigated.The extracts'antifungal activity,minimal inhibitory concentration(MIC)and minimum fungicidal concentration(MFC)values were determined on seven different food-borne mold species.Naringenin was the most abundant phenolic compound in Prunus cerasus and Prunus avium resin extracts,while chlorogenic acid had the highest concentration in Prunus armeniaca resin extracts.The highest antifungal activity and the lowest MIC and MFC values were in the sour cherry tree resin's ethanol extracts(Pantifungal activity was in the sour cherry tree resin's ethanol extract with a 19.24 mm zone diameter on Aspergillus flavus.In contrast,the lowest effect was on Cladosporium cladosporioides with an 8.00 mm zone diameter in apricot tree resin's ethanol extracts(Pantifungals against molds.

关键词： Prunus Resin Ethanol extract Naringenin Aspergillus flavus antifungal

An Epidemiologic Analysis of Vulvovaginal Candidiasis and antifungal Susceptibilities

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Infectious Microbes & Diseases 2022年第3期4卷 131-136页

作者： Fadile Gaye Hösükoğlu Fahriye Ekşi Mehmet Erinmez Mete Gürol Uğur Department of Medical Microbiology Gaziantep University School of MedicineGaziantepTurkey Department of Obstetrics and Gynecology Gaziantep University School of MedicineGaziantepTurkey

Inflammation of the vagina and vulva caused by Candida is called vulvovaginal candidiasis(VVC).Risk factors for VVC include pregnancy,diabetes mellitus,frequent oral sexual intercourse,and the use of tight synthetic underwear and systemic antibiotics.Candida albicans,which belongs to the normal flora of the vagina,is the most common cause of VVC.However,an increase in VVC episodes caused by non-albicans Candida species,including Candida glabrata,Candida tropicalis,Candida krusei and Candida parapsilosis,has been reported.In this study,a total of 100 Candida isolates obtained from patients with vaginitis symptoms were evaluated.The susceptibility of the Candida strains to amphotericin B,itraconazole,fluconazole,ketoconazole,voriconazole and caspofungin was investigated using the reference broth microdilution method.Risk factors and demographic characteristics of the patients and the identified Candida species were also investigated.Among the 100 Candida strains isolated from vaginal samples,47(47%)were C.albicans,43(43%)C.glabrata,5(5%)C.kefyr,2(2%)C.krusei,2(2%)C.tropicalis and 1(1%)was Candida guilliermondii.The incidences of Candida susceptibility to caspofungin,fluconazole,itraconazole,voriconazole,ketoconazole and amphotericin B were 75%,35%,27%,80%,97%and 100%,respectively.Also,there was a significant difference in antifungal susceptibility among patients belonging to certain risk groups,such as patients previously using antibiotics and recurrent cases.Prevalence of non-albicans Candida species and antifungal resistance,especially against azoles,are both increasing,and certain risk factors should be monitored strictly.

关键词： Candida antifungal vulvovaginal candidiasis fluconazole

antifungal activity and antidiarrheal activity via antimotility mechanisms of (-)-fenchone in experimental models

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World Journal of Gastroenterology 2020年第43期26卷 6795-6809页

作者： Michelle Liz de Souza Pessoa Leiliane Macena Oliveira Silva Maria Elaine Cristina Araruna Catarina Alves de Lima Serafim Edvaldo Balbino Alves Junior Alessa Oliveira Silva Matheus Marley Bezerra Pessoa Hermes Diniz Neto Edeltrudes de Oliveira Lima Leonia Maria Batista Department of Pharmaceutical Sciences IPeFarMFederal University of ParaibaJoao Pessoa 58051-970ParaibaBrazil Health Sciences Center Federal University of ParaibaJoaoPessoa 58051-970ParaibaBrazil Postgraduate Program in Natural and Synthetic Bioactive Products Universidade Federal da ParaibaJoão Pessoa 58051-900Brazil

BACKGROUND(-)-Fenchone is a bicyclic monoterpene present in essential oils of plant species,such as Foeniculum vulgare and Peumus boldus,used to treatment of gastrointestinal diseases.Pharmacological studies report its anti-inflammatory,antioxidant,and antinociceptive activity.AIM To investigate antidiarrheal activity related to gastrointestinal motility,intestinal secretion and antimicrobial activity.METHODS A castor oil-induced diarrhea model was used to evaluate antidiarrheal activity.Intestinal transit and gastric emptying protocols were used to assess a possible antimotility effect.Muscarinic receptors,presynaptic α2-adrenergic and tissue adrenergic receptors,KATP channels,nitric oxide were investigated to uncover antimotility mechanisms of action and castor oil-induced enteropooling to elucidate antisecretory mechanisms.The antimicrobial activity was evaluated in the minimum inhibitory concentration model,the fractional inhibitory concentration index using the(-)-fenchone association method with standard antifungal agents.RESULTS(-)-Fenchone(75,150 and 300 mg/kg)showed antidiarrheal activity,with a significant decrease in the evacuation index.This activity is possibly related to a percentage of reduced intestinal transit(75,150 and 300 mg/kg).The antimotility effect of(-)-fenchone decreased in the presence of pilocarpine,yohimbine,propranolol,L-NG-nitroarginine methyl ester or glibenclamide.In the enteropooling model,no reduction in intestinal fluid weight was observed.(-)-Fenchone did not show antibacterial activity;on the other hand,inhibits the growth of strains of fungi with a minimum fungicide concentration of 32μg/mL.However,when it was associated with amphotericin B,no synergism was observed.CONCLUSION The antidiarrheal effect of(-)-fenchone in this study involves antimotility effect and not involve antisecretory mechanisms.(-)-Fenchone presents antifungal activity;however,it did not show antibacterial activity.

关键词： (-)-Fenchone Monoterpenes Diarrhea Motility antifungal

antifungal activity of Ocimum sanctum Linn.(Lamiaceae) on clinically isolated dermatophytic fungi

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Asian Pacific Journal of Tropical Medicine 2011年第8期4卷 654-657页

作者： Balakumar S Rajan S Thirunalasundari T Jeeva S Department of Chemistry and Biosciences SASTRA UniversitySrinivasa Ramanujan Centre.Kumbakonam- 612001Tamil NaduIndia Department of Microbiology M.R.Government Arts CollegeMannargudi.Thriuvarur District.Tamil NaduIndia Department of Biotechnology Bharathidasan UniversityTiruchirappalli-620 024Tamil Nadu.India Centre for Biodiversity and Biotechnology.Department of Botany Nesamony Memorial Christian College.Marthandam-629 165Tamil Nadu.India

Objective:To assess antifungal activity of Ocimum sanctum leaves against dermatophytic fungi. Methods:antifungal activity of Ocimum sanctum leaves was measured by 38 A NCCLS method. Minimum inhibitory concentration(MIC) and minimum fungicidal concentration(MFC) of various extracts and fractions of Ocimum sanctum leaves were also determined.Results:Ocimum sanctum leaves possessed antifungal activity against clinically isolated dermatophytes at the concentration of 200μg/mL.MIC and MFC were high with water fraction(200μg/mL) against dermatophytic fungi used.Conclusions:Ocimum sanctum has antifungal activity,and the leaf extracts may be a useful source for dermatophytic infections.

关键词： antifungal activity Dermatophytosis Epidermophyton floccosum Minimum fungicidal concentration Microsporum sp Minimum inhibitory concentration Ocimum sanctum Trichophyton sp

antifungal Evaluation of Copper(Ⅱ) Complex from a Schiff Base Derivative of Pyrazine on Schizosaccharomyces pombe

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Chinese Journal of Structural Chemistry 2019年第1期38卷 95-102,4页

作者：杨平 School of Environment Jinan University

A new copper(Ⅱ) complex of CuLCl_2, where L = N^1-(1-pyrazin-2-yl-ethylidene)-ethane-1,2-diamine, a tridentate Schiff base derived from 2-acetylpyrazine has been prepared. The complex has been characterized by FT-IR, elemental analysis and single-crystal X-ray diffraction studies. Structural studies reveal that CuLCl_2 is a mononuclear copper(Ⅱ) complex with distorted square pyramidal geometry. antifungal activity of CuLCl_2 was investigated by use of microcalorimetric measurement system and evaluated against S. pombe. It has high antifungal activity with IC_(50) = 213 μg/mL.

关键词： antifungal agents copper Schiff bases pyrazine S.pombe

antifungal Secondary Metabolites Isolated from Mangrove Rhizosphere Soil-Derived Penicillium Fungi

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Journal of Ocean University of China 2020年第3期19卷 717-721页

作者： SHEN Nanxing LIANG Zhaoyang LIU Qing TU Chuandeng DONG Kunming WANG Changyun CHEN Min Marine Science&Technology Institute College of Environmental Science&EngineeringYangzhou UniversityYangzhou 225127China Key Laboratory of Marine Drugs the Ministry of Education of ChinaSchool of Medicine and PharmacyOcean University of ChinaQingdao 266003China Laboratory for Marine Drugs and Bioproducts Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China

Fungi isolated from mangrove rhizosphere soil of the South China Sea were investigated for the production of potential antifungal metabolites. With 28 fungal isolates, the strains Penicillium javanicum HK1-23 and P. janthinellum HK1-6 showed significant antifungal activities. A bioassay-guided investigation of the two fungal strains led to the isolation of two secondary metabolites, brefeldin A and penicillic acid, with high yields of 143 and 423 mg L^-1, respectively. Penicillic acid showed potent antifungal activities toward Rhizoctonia solani and R. cerealis, with 67.5% and 76% growth inhibition, respectively, at 50 μg mL^-1. Brefeldin A showed strong activity toward R. cerealis, with 56.4% growth inhibition at 50 μg mL^-1. The research highlights the importance of exploring microbes from mangrove rhizosphere soil for the identification of bioactive metabolites for future fungicide development.

关键词： mangrove rhizosphere soil-derived fungus Penicillium brefeldin A penicillic acid antifungal

antifungal Enantiomeric Styrylpyrones from Sanrafaelia ruffonammari and Ophrypetalum odoratum

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Natural Products and Bioprospecting 2014年第2期4卷 129-133页

作者： Hamisi M.Malebo Charles Kihampa Clarence A.Mgina Fortunatus Sung’hwa Reiner Waibel Stephan A.Jonker Mayunga H.H.Nkunya Department of Traditional Medicine Research National Institute for Medical ResearchP.O.Box 9653Dar es SalaamTanzania Department of Environmental Science and Management Ardhi UniversityP.O.Box 35176Dar es SalaamTanzania Department of Chemistry University of Dar es SalaamP.O.Box 35061Dar es SalaamTanzania Department of Pharmaceutical Chemistry Institute of PharmacyUniversity of ErlangenSchuhstrasse 1991052 ErlangenGermany

Phytochemical investigation of Sanrafaelia ruffonammari Verd and Ophrypetalum odoratum Diels that belongs to the rare genera confined to East African coastal forests led to the isolation of enantiomeric styrylpyrone dimer,(±)-5-methoxy-7-phenyl-[4-methoxy-2-pyronyl]-1-(E)-styryl-2-oxabicyclo-[4.2.0]-octa-4-en-3-one(1)alongside(?)-6-styryl-7,8-epoxy-4-methoxypyran-2-one(2)and the enantiomeric(?)-(3)and(-)-6-styryl-7,8-dihydroxy-4-methoxypyran-2-ones(4).Their structures were established by means of spectroscopic methods.In this paper we reveal for the first time the occurrence of styrylpyrones in East African biodiversity.(?)-6-Styryl-7,8-epoxy-4-methoxypyran-2-one(2)and the dihydroxystyrylpyrone enantiomer(3)showed in vitro antifungal activity against Candida albicans at a concentration of 24.4 and 26.2 lM with zones of inhibition of 17 and 9 mm,respectively.Compound 2 exhibited strong activity in the brine shrimp test with LC50=1.7 lg/mL.Their high cytotoxic and antifungal activities render them candidates for further scientific attention for drug development programs against cancer and microbial infections.

关键词： Sanrafaelia ruffonammari Verd Ophrypetalum odoratum Diels Styrylpyrones antifungal