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Phenothiazine vs 5HT3 Antagonist Prophylactic Regimens to Prevent Post‐Anesthesia Care Unit Rescue antiemetic: An Observational Study

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Open Journal of Anesthesiology 2015年第2期5卷 27-32页

作者： Joseph R. Ruiz Joe E. Ensor Jeffrey W. Lim Antoinette Van Meter Thomas F. Rahlfs Department of Anesthesiology and Perioperative Medicine The University of Texas MD Anderson Cancer Center Houston USA Department of Biostatistics The University of Texas MD Anderson Cancer Center Houston USA

Purpose: Our practitioners are asked to consider a patient’s postoperative nausea and vomiting (PONV) risk profile when developing their prophylactic antiemetic strategy. There is wide variation in employed strategies, and we have yet to determine the most effective PONV prophylactic regimen. The objective of this study is to compare prophylactic antiemetic regimens containing: phenothiazines to 5HT3 antagonists for effectiveness at reducing the incidence of Post‐Anesthesia Care Unit (PACU) rescue antiemetic administration. Methods: This is an observational study of 4392 nonsmoking, women who underwent general anesthesia for breast surgery from 1/1/2009 through 6/30/2012. Previous history of PONV or motion sickness (HxPONV/MS) and the use of PACU opioids were recorded. Prophylactic antiemetic therapy was left to the discretion of the anesthesia care team. We compared phenothiazines and 5HT3 antagonists alone and with a glucocorticoid to determine the most effective treatment regimen in our practice for the prevention of the administration of PACU rescue antiemetics. Results: Patients who received a phenothiazine regimen compared to a 5HT3 antagonist regimen were less likely to have an antiemetic administered in the PACU (p = 0.0100) and this significant difference in rates holds in a logistic regression model adjusted for HxPONV/MS and PACU Opioid use (p = 0.0103). Conclusions: Based on our findings our clinicians are encouraged to administer a combination of a phenothiazine and a glucocorticoid in female, nonsmoking surgical breast patients for the prevention of PACU rescue antiemetic administration.

关键词： Phenothiazines 5HT3 Antagonists Prophylactic antiemetics PACU antiemetic Administration

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Effect of antiemetic Agents on Hiccups during Chemotherapy in Patients with Lung Cancer

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Pharmacology & Pharmacy 2018年第4期9卷 124-133页

作者： Shinya Toriumi Kazuharu Nakazawa Masaru Shoji Department of Pharmacy National Hospital Organization East Saitama Hospital Hasuda Saitama Japan Department of Pharmacy National Hospital Organization Kanagawa Hospital Hadano Kanagawa Japan Department of Pharmacodynamics Meiji Pharmaceutical University Kiyose Tokyo Japan

Hiccups commonly occur in patients undergoing chemotherapy for lung cancer and may diminish their motivation for treatment. Therefore, it is important to characterize the hiccups and their risk factors. We examined the medical records of 120 patients with lung cancer during their initial chemotherapy and extracted data on the patients’ profiles and the onset, duration, and severity of their hiccup episodes. We found the incidence of hiccups to be 19.2% among the patients. Hiccups appeared within 3 days of beginning the chemotherapy and disappeared within 4 days. Hiccups hindered sleep in two patients. The characteristics of the hiccups episodes in our study were not different from those of previous studies. We also investigated distinctive features of the patients who developed hiccups. The occurrence of hiccups was associated with gender, age, and the treatment with platinum agents. antiemetic agents, dexamethasone and neurokinin-1 receptor antagonists, also showed significant effects on hiccup episodes. Although the dose-responsive effect of dexamethasone on hiccups was insignificant and the effects of two neurokinin-1 receptor antagonists, aprepitant and fosaprepitant, on hiccups appeared identical. From these results, we suggest that a high incidence of hiccups may be anticipated with a prophylactic use of antiemetic agents, dexamethasone and neurokinin-1 receptor antagonists.

关键词： Hiccups Dexamethasone Neurokinin-1 Receptor Antagonist antiemetic Agents Lung Cancer

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Use of ethnomedicinal plants for prophylaxis and management of postpartum complications among the Marwari community of Jodhpur District of Rajasthan

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Food Quality and Safety 2017年第3期1卷 203-209页

作者： Manoj Goyal Lachoo Memorial College of Science and Technology Pharmacy WingJodhpur 342008RajasthanIndia

OBJECTIVES:The days and weeks following childbirth,the postpartum period,is a critical phase in the lives of mothers and newborn babies due to risk of postpartum complications associated with *** plants have been used judiciously during pregnancy to assist childbirth and for postpartum care in various ethnic communities around the *** are extensively used for prophylaxis and management of postpartum complications in the Jodhpur District of Rajasthan,*** aim of this study was to document use of such ethnomedicinal *** AND METHODS:Survey was conducted to document the use of ethnomedicinal *** selected plants were searched for reports on their pharmacological activities on Scopus and Google scholar RESULTS:Use of eighteen ethnomedicinal plants was documented for the prophylaxis and management of postpartum complications from local ***:Zingiber officinale,Asparagus racemosus,Trapa natans,Acacia senegal,Trachyspermum ammi,Piper longum,and Symplocos racemosa possessing galactagogue,uterine tonic,diuretic,antiemetic,and wound healing activity were found to be most commonly used ethnomedicinal plants.

关键词： postpartum medicinal plants galactagogue uterine tonic diuretic antiemetic wound healing.

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Construction and effectiveness of vomit-free ward

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Frontiers of Nursing 2019年第3期6卷 183-189页

作者： Zhi-Qi Yao Song-Wang Xiao-Ping Zhou Yu-Ling Luo Qiang Ao Jing-Xia Miao Department of Oncology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Department of Gynecology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China

Objective:To build a vomit-free ward of scientific and standardized management mode,and to evaluate its clinical effects on preventing nausea and vomiting in patients undergoing ***:A total of 200 patients suffering from nausea and vomiting were randomly selected from the registration system,from which 120 cases were enrolled according to the inclusion and exclusion *** subjects were divided into control group and observation group(60 patients in each).Both of the two groups received routine nursing care,while the treatment group subjects lived in the vomit-free wards where extra nursing interventions were applied to prevent chemotherapy-induced nausea and vomiting(CINV),with constant observation of the frequency and severity of nausea and *** outcomes of the subjects from both the groups as well as nurses’ cognition level of CINV were compared after four chemotherapy ***:The difference in the scoring for the frequency and severity of nausea and vomiting in two groups was statistically significant(P <0.05).The scores of nurses’ cognition level of CINV were compared between before and after the interventions,and the difference had statistical significance(P <0.05).Conclusion:The management mode aiming to build vomit-free wards could decrease the incidence of CINV in patients during chemotherapy,and at the same time increased the cognitive level of nursing staff toward CINV,which is of great value in clinical practice and is worthy of further application.

关键词： tumor nausea and vomiting no vomiting ward nursing chemotherapy antiemetic

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Propofol with Varied Functions: A Potential Therapeutic Opportunity for Postoperative Nausea, Vomiting and Pruritus—A Narrative Review

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Open Journal of Anesthesiology 2024年第2期14卷 13-24页

作者： Thomas W. Anabah Fidelis Bayor David Z. Kolbila Terence Kunfire Dakurah Sylvanus Kampo Juventus B. Ziem Anaesthesia Unit Habana Medical Services Tamale Ghana Department of Anaesthesiology Lawra Municipal Hospital Ghana Health Service Lawra Ghana Department of Obstetrics and Gynecology School of Medicine University for Development Studies Tamale Ghana Department of Anaesthesia and Intensive Care School of Medical Sciences C. K. Tedam University of Technology and Applied Sciences Navrongo Ghana Department of Medical Microbiology School of Medical Sciences C. K. Tedam University of Technology and Applied Sciences Navrongo Ghana

Background: Despite the advances in anesthetics and non-pharmacological techniques, the prevalence of postoperative nausea and vomiting in all patients remains high. It is one of the most common distressing symptoms that cause dissatisfaction among patients after anesthesia and surgery. A sub-hypnotic dose of propofol has been shown to reduce morphine-induced postoperative nausea, vomiting, and pruritus. This review article will provide sufficient knowledge on the role of propofol in minimizing opioid-induced postoperative nausea, vomiting, and pruritus by providing detailed information on propofol antiemetic and antipruritic effects, as well as discussions based on empirically available data. Method: We conducted a narrative review of the literature published between 1990 and 2023 from a range of databases;PubMed, BioMed Central, Biosis Previews, Nature, International Pharmaceutical Abstracts, Springer-Link, and Elsevier. Discussion and Conclusion: The literatures reviewed in this study have demonstrated that propofol may have diverse therapeutic effects including antiemetic and antipruritic. The antiemetic effect of propofol may be an effective therapeutic approach for the prevention of postoperative nausea and vomiting. The literature also demonstrated that the use of propofol for sedation during surgery may as well ameliorates opioids induced postoperative pruritus, which may be beneficial to surgical patients. Also, it was demonstrated that prophylactic use of propofol may be an effective way of preventing nausea and vomiting and pruritus during opioid use.

关键词： Propofol Nausea Vomiting antiemetic Antipruritic Surgery

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