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Pazopanib-induced posterior reversible encephalopathy syndrome with possible syndrome of inappropriate secretion of antidiuretic hormone: an incidental or pathophysiological association?

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Neural Regeneration Research 2020年第6期15卷 1166-1168页

作者： Jonathan Wong So Bérenger Largeau Frédérique Beau-Salinas Stephan Ehrmann Christophe Magni Jérome Meunier CHR d’Orléans Service d’Oncologie MédicaleOrléansFrance CHRU de Tours Centre d’Investigation Clinique-CIC INSERM 1415ToursFrance CHRU de Tours Service de PharmacosurveillanceCentre Régional de Pharmacovigilance Centre-Val de LoireToursFrance Universitéde Tours INSERMCentre d’étude des pathologies respiratoires(CEPR)-UMR 1100CHRU de ToursService de Médecine Intensive RéanimationCIC INSERM 1415réseau CRICS-TRIGGERSEPToursFrance CHR d’Orléans Service de NeuroradiologieOrléansFrance

Introduction:Pazopanib is an oral protein kinase inhibitor(PKI)that targets vascular endothelial growth factor(VEGF)receptors,fibroblastic growth factor receptors,platelet-derived growth factor receptors,and stem cell factor that inhibits VEGF-induced cellular proliferation.Pazopanib is approved for use in advanced renal cell carcinoma and subtypes of advanced soft-tissue sarcoma(Deguchi et al.,2018).Major adverse drug reactions of pazopanib include hypertension,high-grade hyponatremia and posterior reversible encephalopathy syndrome(PRES)(Berardi et al.,2016;Deguchi et al.,2018).In clinical trials,few investigations have been conducted to determine the aetiology of PKI-associated hyponatremia,the mechanism remains therefore unknown.Only rare cases of PKI-induced syndrome of inappropriate secretion of antidiuretic hormone(SIADH)(Largeau et al.,2019),and none with pazopanib,have been reported.PRES is a clinical and radiological entity where a bilateral white matter oedema,occurring predominantly in the posterior occipital and parietal lobes,is associated with several neurologic symptoms.Interestingly,a recent review suggests that SIADH could be a symptom of PRES(Largeau et al.,2019).To our knowledge,this is the first case published where pazopanib-induced PRES occurs contemporaneously with possible SIADH.

关键词： al. SIADH antidiuretic

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Natural killer/T-cell lymphoma with concomitant syndrome of inappropriate antidiuretic hormone secretion: A case report and review of literature

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World Journal of Clinical Cases 2018年第13期6卷 694-702页

作者： Quan-Bo Liu Rui Zheng Department of Respiratory Medicine Shengjing Hospital of China Medical University

We report a case of natural killer(NK)/T-cell lymphoma with concomitant syndrome of inappropriate antidiuretic hormone secretion(SIADH).The patient was a 64-yearold woman with a history of nasopharyngeal carcinoma of over 30 years.She was admitted with a chief complaint of intermittent fever for 2 mo.Palpation after admission indicated a swollen lymph node below the left jaw.Multiple imaging examinations on admission indicated multiple enlarged lymph nodes throughout the body.We performed a left submandibular lymph node biopsy,and the results revealed NK/T-cell lymphoma.A biochemical examination indicated Epstein-Barr virus positivity.At the same time,the patient developed hyponatremia.Based on her laboratory examination and clinical manifestation,decreased plasma osmolality,urine osmolality greater than plasma osmolality,lack of skin swelling,normal blood pressure,normal renal function,no adrenal function detected on serology,and no abnormalities in imaging examination of the adrenal glands,the likelihood of SIADH in the patient was high.After fluid restriction and administration of sodium chloride,the patient’s blood sodium level gradually increased.Subsequently,the immune function of the patient declined,there were severe symptoms of infection,and she died of respiratory failure.NK/T-cell lymphoma associated with SIADH has not,to our knowledge,been previously reported in PubMed.This case emphasizes the importance of monitoring serum ion levels,especially serum sodium,in patients with NK/T-cell lymphoma.

关键词： Epstein-Barr virus Case report Literature review Syndrome of inappropriate antidiuretic hormone secretion Natural killer/T-cell lymphoma

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Case of inappropriate ADH syndrome:Hyponatremia due to polyethylene glycol bowel preparation

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World Journal of Gastroenterology 2014年第34期20卷 12350-12354页

作者： Sun-Hye Ko Chul-Hyun Lim Jae-Young Kim Seung Hun Kang Myong Ki Baeg Hyun Jin Oh Division of Endocrinology and Metabolism Department of Internal MedicineCollege of MedicineThe Catholic UniversitySeoul 137-701South Korea Division of Gastroenterology Department of Internal MedicineCollege of MedicineThe Catholic University of KoreaSeoul 137-701South Korea

Colonoscopic screening has been reported to reduce deaths from colorectal cancer.Adequate bowel preparation is essential for this and safety is an important issue in choosing the methods.Polyethylene glycol(PEG)is regarded as a safe method for cleansing,especially compared with oral sodium phosphate.Here,we present a case of hyponatremia caused by the syndrome of inappropriate antidiuretic hormone(ADH)syndrome after PEG precolonoscopic cleansing resulting in generalized tonic-clonic seizures.A 62-year-old women had ingested PEG for precolonoscopic bowel cleansing.While waiting for the colonoscopy,she developed a stuporous mentality and generalized tonic-clonic seizures,which did not correlate with brain magnetic resonance imaging.Her serum sodium level was 113 mEq per liter and laboratory analyses were consistent with inappropriate ADH syndrome.Her thyroid and adrenal functions were normal.There were no malignancies,infections,respiratory disorders or central nervous disorders and she had no history of taking either diuretics or other medications,which might have caused inappropriate ADH syndrome.She was treated with 3%hypertonic saline and showed a complete neurological recovery as her sodium levels recovered.Follow-up visits showed the patient to have a normal sodium level without neurologic deficits.This case shows that inappropriate ADH syndrome can be caused by PEG preparation,which implies that physicians have to be aware of the possible side effects of this colonic cleansing approach and mindful of the possible ensuing symptoms.

关键词： Inappropriate antidiuretic hormone syndrome Colono

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Desmopression is an effective adjunct treatment for reversing excessive hyponatremia overcorrection

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World Journal of Clinical Cases 2013年第5期1卷 155-158页

作者： Kamel A Gharaibeh Matthew J Craig Christian A Koch Anna A Lerant Tibor Fülp va Csongrádi Department of Internal Medicine University of Mississippi Medical CenterJacksonMS 39216-4505United States Department of Anesthesiology University of Mississippi Medical CenterJacksonMS 39216-4505United States Department of Medicine University of Debrecen Medical and Health Science CentreUniversity of Debrecen4032 DebrecenHungary

We report a case of a 50-year-old malnourished African American male with hiccups, nausea and vomiting who was brought to the Emergency Department after repeated seizures at home. Laboratory evaluations revealed sodium(Na+) 107 mmol/L, unmeasurably low potassium, chloride antidiuretic hormone analog, such as desmopressin can limit urine output and prevent an unpredictable rise of the serum sodium.

关键词： Hyponatremia Hypokalemia Overcorrection Polyuria antidiuretic hormone Vasopressin Desmopressin Osmotic demyelination syndrome Central pontine myelinolysis

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去氨加压素片服用方法影响尿崩症治疗效果的病例分析

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中国医刊 2017年第4期52卷 22-24页

作者：唐彦石二霞孔艳华许岭翎赵维纲金自孟朱惠娟刘赫中国医学科学院北京协和医院药剂科北京100730 内蒙古自治区呼和浩特市第一医院药剂科内蒙古呼和浩特010020 安徽省亳州市人民医院内分泌科安徽亳州236800 中国医学科学院北京协和医院内分泌科北京100730

中枢性尿崩症（diabetes insipidus,DI）是由抗利尿激素（antidiuretic hormone,ADH）缺乏所致的肾脏浓缩功能障碍,可出现多尿、夜尿增多和烦渴等症状。去氨加压素是一种ADH类似物,几乎是所有中枢性尿崩症患者的首选药物[1]。去氨加压... 详细信息

中枢性尿崩症（diabetes insipidus,DI）是由抗利尿激素（antidiuretic hormone,ADH）缺乏所致的肾脏浓缩功能障碍,可出现多尿、夜尿增多和烦渴等症状。去氨加压素是一种ADH类似物,几乎是所有中枢性尿崩症患者的首选药物[1]。去氨加压素片为成功应用于临床的肽类激素口服剂型治疗药物[2],临床效果明显,本文报道1例由于个体差异,进食导致药物敏感度降低的患者。

关键词：去氨加压素中枢性尿崩症服用方法 antidiuretic 夜尿增多多尿类似物抗利尿激素肽类激素口服剂型

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抗肿瘤药物对肾脏的影响

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国外医学(内科学分册) 1985年第9期 412-415页

作者：朱明德陈梅芳上海第二医学院附属仁济医院上海第二医学院附属仁济医院

近年来,肿瘤病人的肾脏问题越来越受到重视,这是由于: ①许多肿瘤可侵犯肾脏,并成为主要预后因素之一; ②肾脏是某些抗癌药物的主要排泄器官,肾功能减退时抗癌药物之毒性可增强; ③某些抗肿瘤药物可损害肾脏。肿瘤患者的几个主要肾脏... 详细信息

近年来,肿瘤病人的肾脏问题越来越受到重视,这是由于: ①许多肿瘤可侵犯肾脏,并成为主要预后因素之一; ②肾脏是某些抗癌药物的主要排泄器官,肾功能减退时抗癌药物之毒性可增强; ③某些抗肿瘤药物可损害肾脏。肿瘤患者的几个主要肾脏问题列于表1,本文主要综述抗肿瘤药物对肾脏的影响。抗肿瘤治疗的肾脏并发症肾脏并发症在抗肿瘤治疗中可能发生的肾脏并发症分为10类(见表2),其中有些是抗肿瘤治疗直接引起,如出血性膀胱炎、抗利尿激素分泌不当综合征(syndrome of inapropriate antidiuretic hormone,SIADH)等;另一些则通过某种间接因素引起,如高血钙,弥散性血管内

关键词：抗肿瘤药物 antidiuretic 肾功能肿瘤病排泄器官 SIADH 肾小管损害急性肾功能衰竭抗癌药物肾毒性

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DOES ADRENAL GLAND PARTICIPATE IN PRESSOR RESPONSE OF VAGUS POSTPITUITARY REFLEX?

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Chinese Science Bulletin 1982年第1期27卷 108-111页

作者：唐正荣 First Staff Hospital Jianghan Petroleum Administration Qianjiang Hubei Province

H. C. Chang et al. observed the release of acetycholine (ACH) in the central nervous system during stimulating the central end of the vagus nerve on the isolated head preparation of the dog. It is this ACH that releas... 详细信息

关键词： reflex vasopressin antidiuretic bilateral stimulation stimulating frontal adrenal pressor longer

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Respiratory tract tumor

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外科研究与新技术 1993年第1期 40-42页

930125 Dynamic study on plasma antidiureticChina Medical Abstracts(Internal Medicine) hormone before and after resection of lung can-cers.YANG Jun(杨俊),et al.Nanfang Hosp,Guangzhou.Chin J Oncol 1992;14(5):360-361.Plasma antidiuretic hormone(ADH)was as-sayed before and after resection of lung cancers.The results showed that the plasma ADH in thecontrol group was 11.6±4.8Pg/ml in contrastto higher levels in the lung cancer patients.TheADH level was the highest in patients

关键词： antidiuretic adenoma Guangzhou papillary modality prognosis Tuberc operated elevated DNA

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