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Insulin-mimetic compound hexaquis(benzylammonium) decavanadate is antilipolytic in human fat cells

World Journal of Diabetes 2017年第4期8卷 143-153页

作者： Christian Carpéné Silvia Garcia-Vicente Marta Serrano Luc Marti ChloéBelles Miriam Royo Jean Galitzky Antonio Zorzano Xavier Testar Institut des Maladies Métaboliques et Cardiovasculaires I2MCINSERM U1048Institut.National de la Santé et de la Recherche Médicale &Université Paul Sabatier Genmedica Therapeutics S.L. Esplugues de Llobregat Combinatorial Chemistry Unit Barcelona Science ParkUniversity of Barcelona CIBER-BBN Networking Centre on BioengineeringBiomaterials and Nanomedicine Departament de Bioquimica i Biomedicina Molecular Facultat de BiologiaUniversitat de Barcelona CIBER de Diabetes y Enfermedades Metabólicas Asociadas(CIBERDEM) Instituto de Salud Carlos Ⅲ Institute for Research in Biomedicine(IRB Barcelona) the Barcelona Institute of Science and Technology

AIM To assess in rodent and human adipocytes the antilipolytic capacity of hexaquis(benzylammonium) decavanadate(B6V10), previously shown to exert antidiabetic effects in rodent models, such as lowering free fatty acids(FFA) and glucose circulating *** Adipose tissue(AT) samples were obtained after informed consent from overweight women undergoing plastic surgery. Comparison of the effects of B6V10 and reference antilipolytic agents(insulin,benzylamine,vanadate) on the lipolytic activity was performed on adipocytes freshly isolated from rat, mouse and human AT. Glycerol release was measured using colorimetric assay as an index of lipolytic activity. The influence of B6V10 and reference agents on glucose transport into human fat cells was determined using the radiolabelled 2-deoxyglucose uptake *** In all the species studied, B6V10 exhibited a dosedependent inhibition of adipocyte lipolysis when triglyceride breakdown was moderately enhanced by β-adrenergic receptor stimulation. B6V10 exerted on human adipocyte a maximal lipolysis inhibition of glycerol release that was stronger than that elicited by insulin. However, B6V10 did not inhibit basal and maximally stimulated lipolysis. When incubated at dose ≥ 10 μmol/L, B6V10 stimulated by twofold the glucose uptake in human fat cells, but-similarly to benzylamine-without reaching the maximal effect of insulin, while it reproduced one-half of the insulin-stimulation of lipogenesis in mouse fat cells. CONCLUSION B6V10 exerts insulin-like actions in adipocytes, including lipolysis inhibition and glucose transport activation. B6V10 may be useful in limiting lipotoxicity related to obesity and insulin resistance.

关键词： Adipocyte Lipolysis Amine oxidases Insulin resistance Obesity Hydrogen peroxide Vanadium antidiabetics

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Isolation,Purification and Hypoglycemic Activity of Extracellular Polysaccharides from Laetiporus Sulphureus Mycelium

Isolation,Purification and Hypoglycemic Activity of Extracel...

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作者： CHIBUIKE AUGUSTUS CHIEMEKA 沈阳农业大学

学位级别：硕士

The polysaccharides with hyperglycemic activity from Laetiporus sulphureus was extracted and characterized,as well as establishing a nitrogen restriction strategy for increasing polysaccharide *** main research content of this paper is listed below:*** DNA of the strain obtained from Xia matang(Benxi,Liaoning province)was separated by CTAB *** PCR and sequence detection,a 500-750 bp sequence was obtained,and the length of nucleic acid sequence was consistent with the characteristics of fungal gene *** SEM obsered that the mycelium of this strain appeared a lock-form structure with spherical *** sequence alignment and morphological observation,the strain was identified Laetiporus *** six kinds of nitrogen source fermentation test,inorganic nitrogen(potassium nitrate)and organic nitrogen(peptone)were selected as nitrogen sources for restricted nitrogen *** results showed that the optimal nitrogen restriction condition for extracellular polysaccharide of *** mycelium production was 5 mmol/L of potassium nitrate and4 days of *** these conditions,the yield of crude polysaccharide(named e LSP)could reach 14.655 mg/m *** e LSP was isolated by cellulose ion-exchange chromatography and obtained three fractions,which were named as e LSP-I,e LSP-II and e LSP-III,*** antioxidant capacity of the three polysaccharide fractions was detected and the result showed that e LSP-II had the highest DPPH scavenging ***,the e LSP-II was used for further purifing with Sephadex G-100,and a single fraction was collected,named as e *** properties of e LSP-IIa were characterized by HPGPC,FT-IR and *** monosaccharide composition analysis revealed that e LSP-IIa was composed of Glc,Gal,Ara and Gal A with the ratio of 91.0,6.9,1.2 and 0.9,*** molecular weight detecting by HPGPC exhibited that e LSP-IIa was about 8.8×10～*** of the e LSP-IIa revealed a rod-

关键词： Laetiporus sulphureus Nitrogen limitation Antioxidant Separation and purification antidiabetics

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Assessment of traditional knowledge of the antidiabetic plants of Darjeeling and Sikkim Himalayas in the context of recent phytochemical and pharmacological advances

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Journal of Integrative Medicine 2016年第5期14卷 336-358页

作者： Rakhi Chakraborty Swarnendu Roy Vivekananda Mandal Department of Botany APC Roy Government College Department of Botany Kurseong College Plant Physiology and Biochemistry Laboratory Department of BotanyUniversity of Gour Banga

Darjeeling and Sikkim Himalayas, a part of Eastern Himalayan Hotspot, is characterized by its richness of plant diversity. Herbal medicine has been one of the most popular and reliable healing practices among the different ethnic groups of this region for ages. However, the lack of documentation practice by the traditional healers has led to obscurity regarding the efficacy of herbal medicine among the present generation, though they have to depend on the same quite often. Meanwhile, several reviews have attempted to document the plants used for the treatment of diabetes from this region, but interestingly, very few research works can be obtained regarding the characterization of antidiabetic properties of the plants of this region. Therefore, it demands a better understanding of the potentiality of these plants in the purview of scientific evidence. This review article reports 55 such plant species which have been reported to be frequently used in the treatment of hyperglycemia and our objective was to validate the potentiality of the plants in the light of recent phytochemical and pharmacological researches being carried out Iocallv or elsewhere.

关键词： hyperglycemia antidiabetics antihyperglycemics phytochemicals pharmacological processes herbal medicine

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液质联用检测中药保健品中掺加降糖化学药的方法研究

液质联用检测中药保健品中掺加降糖化学药的方法研究

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2005年全国有机质谱学术交流会

作者：李晓东王瑾张雅军尹利辉中国药品生物制品检定所

目前,口服降糖药在非胰岛素依赖型糖尿病(Ⅱ型糖尿病)的治疗过程中占有重要地位,而国内口服降糖药市场的特点则是以西药为主,中成药为辅的格局。由于口服降糖中成药的价格普遍高于降糖西药,市场上便出现了在一部分中药保健品中非法掺加... 详细信息

目前,口服降糖药在非胰岛素依赖型糖尿病(Ⅱ型糖尿病)的治疗过程中占有重要地位,而国内口服降糖药市场的特点则是以西药为主,中成药为辅的格局。由于口服降糖中成药的价格普遍高于降糖西药,市场上便出现了在一部分中药保健品中非法掺加降糖化学药的情况。糖尿病作为一

关键词： HPLC -MS/MS antidiabetics Illegal adulteration Health Food Chinese Medicine

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