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Inadequate glycaemic control and antidiabetic therapy among inpatients with type 2 diabetes in Guangdong Province of China

引用

Chinese Medical Journal 2008年第8期121卷 677-681页

作者： BI Yan YAN Jin-hua LIAO Zhi-hong LI Yan-bing ZENG Long-yi TANG Kuan-xiao XUE Yao-ming YANG Hua-zhang LI Lu CAI De-hong WU Ge ZHANG Fan LIN Shao-da XIAO Zheng-hua ZHU Da-long WENG Jian-ping Department of Endocrinology First Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong 510080 China Department of Endocrinology Third Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong 510630 China Department of Endocrinology Nanfang Hospital Southern Medical University Guangzhou Guangdong 510515 China Department of Endocrinology Guangdong Provincial People's Hospital Guangzhou Guangdong 510080 China Department of Endocrinology Shenzhen People's Hospital Medical College of Jinan University Shenzhen Guangdong 518020 China Department of Endocrinology Zhujiang Hospital Southern Medical University Guangzhou Guangdong 510282 China Department of Endocrinology Affiliated Hospital of Guangdong Medical College Zhanjiang Guangdong 524001 China Department of Endocrinology Peking University Shenzhen Hospital Shenzhen Guangdong 518036 China Department of Endocrinology First Affiliated Hospital of Medical College of Shantou University Shantou Guangdong 515041 China Department of Endocrinology Guangzhou First Municipal People's Hospital Guangzhou Guangdong 510180 China Department of Endocrinology Drum Tower Hospital Affiliated to Medical College of Nanjing University Nanjing Jiangsu 210008 China

Background Diabetes mellitus has become epidemic in recent years in China. We investigated the prevalence of hyperglycaemia and inadequate glycaemic control among type 2 diabetic inpatients from ten university teaching hospitals in Guangdong Province, China. Methods Inadequate glycaemic control in diabetic patients was defined as HbA1c 〉 6.5%. Therapeutic regimens included no-intervention, lifestyle only, oral antiglycemic agents （OA）, insulin plus OA （insulin＋OA）, or insulin only. antidiabetic managements included monotherapy, double therapy, triple or quadruple therapy. Results Among 493 diabetic inpatients with known history, 75% had HbA1c ≥ 6.5%. inadequate glucose control rates were more frequently seen in patients on insulin＋OA regimen （97%） ,than on OA regimen （71%）（P 〈0.001）, and more frequent in patients on combination therapy （81%-96%） than monotherapy （7,5%）（P 〈0.0,5）. Patients on insulin differed significantly from patients on OA by mean HbA1c, glycemic control rate, diabetes duration, microvascular complications, and BMI （P 〈0.01）. Conclusions This study showed that glycaemic control of type 2 diabetic patients deteriorated for patients who received insulin and initiation time of insulin was usually delayed, it is up to clinicians to move from the traditional stepwise therapy to a more active and early combination antidiabetic therapy to provide better glucose control.

关键词： type 2 diabetes inpatient glycaemic control antidiabetic therapy

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