检索结果-南通市图书馆

STUDIES ON THE RELATIONSHIP BETWEEN THE MO REACTIVITY INDICES AND REVERSIBLE anticholinesterase ACTIVITY OF CUIXINGNING

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Science Bulletin 1990年第2期35卷 139-144页

作者：陈邦华焦克芳纪庆娥宋鸿锵 Institute of Pharmacology and Toxicology 27 Tai Ping Road Belling 100850 PRC

Reversible anticholinesterase (anti-ChE)agents can inhibit the function of acetylcholinesterase (AChE)temporarily and have been used in the treatment of glaucoma and myasthenia gravis, and recently used as analeptic f... 详细信息

关键词： reversible anticholinesterase (anti-ChE)agent Cuixingning molecular orbital(MO)reactivity indices.

Phytochemical profile and ABTS cation radical scavenging,cupric reducing antioxidant capacity and anticholinesterase activities of endemic Ballota nigra *** *** from Turkey

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Coastal Life Medicine 2014年第7期 555-559页

作者： Abdulselam Ertaş Mehmet Boğa Yeter Yeşil Department of Pharmacognosy Faculty of PharmacyDicle University21280 DiyarbakirTurkey Research and Application of Science and Technology Center(DÜBTAM) Dicle University21280 DiyarbakirTurkey Department of Pharmaceutical Technology Faculty of PharmacyDicle University21280 DiyarbakirTurkey Department of Pharmaceutical Botany Faculty of PharmacyIstanbul University34116 IstanbulTurkey

Objective:To evaluate the chemical compositions and biological activities of an endemic Ballota nigra *** ***:Essential oil and fatty acid composition were determined by GC/MS *** cation radical decolourisation and cupric reducing antioxidant capacity assays were carried out to indicate the antioxidant *** anticholinesterase potential of the extracts were determined by Ellman ***:The major compounds in the fatty acid composition of the petroleum ether extract were identified as palmitic(36.0%)and linoleic acids(14.3%).The major components of essential oil were 1-hexacosanol(26.7%),germacrene-D(9.3%)and caryophyllene oxide(9.3%).The water extract indicated higher ABTS cation radical scavenging activity than α-tocopherol and BHT,at 100μg/*** acetone extract showed 71.58 and 44.71%inhibitory activity against butyrylcholinesterase and acetylcholinesterase enzyme at 200μg/mL,***:The water and acetone extracts of Ballota nigra *** can be investigated in terms of both phytochemical and biological aspects to find natural active compounds.

关键词： Lamiaceae Ballota nigra L.subsp.anatolica Fatty acid Essential oil Antioxidant anticholinesterase

Hormetic response of cholinesterase from Daphnia magna in chronic exposure to triazophos and chlorpyrifos

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2011年第5期23卷 852-859页

作者： Shaonan Li Yajun Tan Institute of Pesticide and Environmental Toxicology College of Agriculture and Biotechnology Zhejiang University Hangzhou 310029 China. E-mail: snli@*** Research Institute of Tianjin Product Quality Inspection Technology Tianjin 300384 China

In vivo activity of cholinesterase （ChE） in Daphnia magna was measured at different time points during 21-day exposure to triazophos and chlorpyrifos ranging from 0.05 to 2.50 μg/L and 0.01 to 2.00 μg/L, respectively. For exposure to triazophos, ChE was induced up to 176.5% at 1.5 μg/L and day 10 when measured by acetylthiocholine （ATCh）, whereas it was induced up to 174.2% at 0.5 μg/L and day 10 when measured by butyrylthiocholine （BTCb）. For exposure to chlorpyrifos, ChE was induced up to 134.0% and 160.5% when measured by ATCh and BTCh, respectively, with both maximal inductions detected at 0.1 Ixg/L and day 8. Obvious induction in terms of ChE activity was also detected in daphnia removed from exposures 24 hr after their birth and kept in a recovery culture for 21 days. Results indicated that the enzyme displayed symptoms of hormesis, a characteristic featured by conversion from low-dose stimulation to high-dose inhibition. In spite of that, no promotion in terms of reproduction rate and body size was detected at any tested concentrations regardless of whether the daphnia were collected at end of the 21-day exposure or at end of a 21-day recovery culture. This suggested that induction of ChE caused by anticholinesterases had nothing to do with the prosperity of the daphnia population.

关键词： Daphnia magna anticholinesterase ChE enzyme promotion exposure recovery culture population prosperity

Analysis of chemical composition and bioactive property evaluation of Indian propolis

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2012年第8期2卷 651-654页

作者： R Thirugnanasampandan Sayana Beena Raveendran R Jayakumar PG and Research Department of Biotechnology Kongunadu Arts and Science College Department of Molecular Medicine Faculty of MedicineUniversity of Malaya

Objective:To analyze the chemical composition and to evaluate the bioactive potential of hydroalocoholic extract of ***:Ethanol extract of propolis was analyzed by GCMS,HPTLC and HPLC methods and in vitro antioxidant,anticholinesterase and cytotoxicity assay were ***:GC-MS analysis revealed the presence of fatty acids,alcohols, and *** was identified and quantified by HPTLC and HPLC *** dependent DPPH and hydroxyl radical scavenging activity of hydroalcoholic extract of propolis was calculated as 16.20 and 34.33 μg/mL *** of lipid peroxidation was significant and the IC_(50) value was calculated as 55.56 μg/*** activity was less *** cytotoxic activity against both breast(MCF-7) and lung cancer(A543) cell lines were significant and the IC_(50)value was calculated as 10 and 13 μg/mL ***: These findings showed that bioactive compounds present in propolis will alleviate many diseases and can be used for better human health.

关键词： Propolis Densitometry Quercetin Antioxidant anticholinesterase Cytotoxicity

Biological activities of the Ornithogalum orthophyllum and its in silico ADMET profile

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Traditional Medicine Research 2021年第6期6卷 59-66页

作者： Duygu Taşkın ŞeydaŞentürk Eray Metin Güler Ahmet Doğan Gülden Zehra Omurtag Mizgin Ermanoğlu Turgut Taşkın Department of Analytical Chemistry Hamidiye Faculty of PharmacyUniversity of Health Sciences TurkeyIstanbul 34668Turkey Darıca Leyla Pharmacy Kocaeli 41700Turkey Hamidiye School of Medicine Department of Medical BiochemistryUniversity of Health Sciences TurkeyIstanbul 34668Turkey Department of Pharmaceutical Botany Faculty of PharmacyMarmara UniversityIstanbul 34854Turkey Department of Pharmaceutical Toxicology School of PharmacyIstanbul Medipol UniversityIstanbul 34810Turkey Department of Pharmacognosy Faculty of PharmacyMarmara UniversityIstanbul 34854Turkey

Background:The bulbs and aerial parts of Ornithogalum are used in Turkey both as food and to treat various ailments,and some of its medical applications are well ***,the biological activities of Ornithogalum orthophyllum have not yet been *** objective of this study was to examine the antioxidant,urease and cholinesterase enzyme inhibition,and cytotoxic activities of different extracts obtained from the bulb and aerial parts of the *** *** addition,the absorption,distribution,metabolism,excretion,and toxicity properties of some phenolic compounds in plants were examined in ***:The antioxidant activity of the extracts obtained from the aerial parts of *** was investigated using the 2,2-diphenyl-1-picrylhydrazyl,2,2-azinobis(3-ethylbenzothiazoline-6-sulphonic acid),ferric reducing antioxidant power,and cupric reducing antioxidant capacity *** and cholinesterase enzyme inhibition were determined by using the indophenol and Ellman methods,*** cytotoxic activity of the extracts was measured using a test based on the luminometric readings of the adenosine triphosphate levels of the ***,a free online web server(http://***/pkcsm)was used to predict the properties of the compounds ***:The methanol extract of the aerial parts of *** was observed to have strong antioxidant and acetylcholinesterase enzyme inhibition *** petroleum ether extract of the aerial parts showed the highest anti-urease *** chloroform extract of the aerial parts exhibited the highest cytotoxic effect against A431 human epidermoid carcinoma *** absorption percentages of protocatechuic acid,p-hydroxybenzoic acid,vanillic acid,and p-coumaric acid compounds from the small intestine were between 71.17%and 93.49%,which were quite *** the compounds were predicted to be unable to penetrate the central nervous system due to their inability to cross

关键词： Ornithogalum orthophyllum antioxidant cytotoxic anticholinesterase anti-urease ADMET