检索结果-南通市图书馆

Journal of Clinical and Nursing Research 2024年第1期8卷 196-208页

作者： Seul Gi Lee So-Young Choi Department of Nursing Gyeongsang National University HospitalJinju 52727Korea College of Nursing Gyeongsang National UniversityJinju 52727Korea

Purpose:This research aimed to identify leading factors that affect nurses’compliance with the safe handling of anticancer ***:Data were collected from 114 nurses working in the university hospital and were analyzed through independent t-test,one-way ANOVA,Pearson’s correlation coefficient,and multiple regression analysis using ***:The average level of compliance with the safe handling of anticancer agents was 3.73±0.33 out of 5 *** safety culture(β=0.40,Panticancer *** explained variance for compliance was 28.3%.Conclusion:To enhance the implementation of safety management for anticancer agents,each institution should strive to support human and material resources and enhance specialization in the workplace safety culture through system *** on the results of this study,we suggest research for the development of a training program for anticancer agent safety management.

关键词： anticancer agents Compliance Knowledge Nurse Safety

In vitro studies of polyethyleneimine coated miRNA microspheres as anticancer agents

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2016年第6期9卷 1609-1617页

作者： Irena Rytblat Ning Wu Huangli Xu Aharon Gedanken Xiukun Lin Bar-Ilan Institute for Nanotechnology and Advanced Materials Department of Chemistry Bar-Ilan University Ramat-Gan 52900 Israel Key Laboratory of Experimental Marine Biology Institute of Oceanology Chinese Academy of Sciences Qingdao 26607 I China Department of Pharmacology Capital Medical University Beijing 100069 China

RNA plays important roles as a gene-silencing agent, a therapeutic agent for clinical treatment, and in the differentiation, proliferation, and development of cells. However, RNA is very difficult to work with due to its sensitivity and fragility. Another obstacle in using RNA for gene delivery/silencing is its negative charge, which causes its repulsion by cell membranes, which are also negatively charged. Our recent study showed that miR-125b is upregulated in glioblastoma （GMB） and plays an oncogenic role in GMB cells by promoting cell proliferation and inhibiting apoptosis. Endogenous miR-125b can be blocked by transfection of its antisense RNA molecule, miR-125b antisense （miR-125b-AS）. Thus, miR- 125b-AS can be developed as an RNA-based agent for cancer treatment. However, instability during storage and difficulty in delivery into cells has limited the use of RNA-based therapies thus far. In the current work, we demonstrate a short and simple one-step technique for the preparation of positively charged RNA nanospheres （miR-125b-RNS and miR-125b-AS-RNS） coated with a bioavailable polymer, polyethylenimine （PEI）. These RNA nanospheres are able to penetrate the cell directly without the use of liposomes. Our study confirmed that converting miR-125b and miR-125b-AS into nanospheres is a viable approach for storing RNA. In addition, this study provides evidence that PEI-coated RNA nanospheres have the potential to be used as a novel class of anticancer a^ents.

关键词： nanospheres gene silencing gene delivery polyethylenimine anticancer agents

Alkylating anticancer agents and their relations to microRNAs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Drug Resistance 2019年第1期2卷 1-17页

作者： Bernhard Biersack Organic Chemistry Laboratory University of BayreuthBayreuth 95440Germany

Alkylating agents represent an important class of anticancer *** occurrence and emergence of tumor resistance to the treatment with alkylating agents denotes a severe problem in the clinics.A detailed understanding of the mechanisms of activity of alkylating drugs is essential in order to overcome drug *** particular,the role of non-coding microRNAs concerning alkylating drug activity and resistance in various cancers is highlighted in this *** synthetic and natural alkylating agents,which are approved for cancer therapy,are discussed concerning their interplay with microRNAs.

关键词： Alkylating agents microRNA anticancer agents DNA drug resistance

Novel anticancer agents from plant sources

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国天然药物 2013年第1期11卷 16-23页

作者： Shah Unnati Shah Ripal Acharya Sanjeev Acharya Niyati Pioneer Pharmacy Degree College Vadodara-390019 India Sun Pharma Advanced Research Centre Vadodara-390020 India ~nstitute of Pharmacy Nirma University Sarkhej-Gandhinagar Highway Ahmedabad-382481 India

植物仍然是新药，新药领先和新化学实体的重要来源。植物基于的药发现主要导致了 anticancer 和反传染的代理人的发展，并且继续在临床的试用贡献新领先。自然产品药在药品的照顾起一个主导的作用。几导出植物的混合物成功地当前在癌症... 详细信息

植物仍然是新药，新药领先和新化学实体的重要来源。植物基于的药发现主要导致了 anticancer 和反传染的代理人的发展，并且继续在临床的试用贡献新领先。自然产品药在药品的照顾起一个主导的作用。几导出植物的混合物成功地当前在癌症治疗被采用。有为药的进一步的改进和开发学习的导出植物的细胞毒素的自然产品的许多类。从关于植物 antitumor 代理人的研究导出的新 anticancer 药将连续地被发现。这评论的基本目的是从药用的植物探索最新发现的 anticancer 混合物的潜力，作为为 anticancer 药开发的领先。在地球附近为研究人员和科学家从他们探索植物并且为新药发现的药用的价值将是有用的。

关键词： Cancer anticancer agents Medicinal plants

Discovery of Novel Aromathecin Analogues as Potent anticancer agents by Mitochondrion-Mediated Intrinsic Apoptotic Pathway

在线全文

学校读者我要写书评

暂无评论

Discovery of Novel Aromathecin Analogues as Potent Anticance...

anticancer Activities and QSAR Study of Novel agents with a Chemical Profile of Benzimidazolyl-Retrochalcone

中国化学会·第十五届全国有机合成化学学术研讨会

作者： Jing-Mei Yuan Kai Wei Nan-Ying Chen Cheng-Xue Pan 苏桂发 State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical Sciences Guangxi Normal University 广西师范大学

Natural products have historically been the most important source for discovery of therapeutic *** the ongoing work in our group to identify novel antitumor scaffold based on natural *** aromathecin analogues were designed, synthesized and evaluated for antiproliferative activities against four selected human cancer cell lines(HepG-2, T24, NCI-H460 and MGC-803) and one normal human cell lines(HL-7702) in *** results indicated that most of them exhibited potent anticancer activity with the IC value range from 0.31 to 11.97 μ*** mechanism studies suggested that the potential compound 5b exhibited efficient DNA cleaving ability, resulting in S/G2 phase cell cycle arrest and mitochondria mediated apoptosis which could be further confirmed by the results of mitochondrial dysfunction, reactive oxygen species(ROS) generation, altered Ca levels and the expression levels of correlation *** together, these mechanistic insights indicate that compound 5b could be novel anticancer drug candidates.

关键词： aromathecin analogues mitochondrial mediated apoptosis anticancer agents

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Open Journal of Medicinal Chemistry 2020年第3期10卷 113-127页

作者： Ouattara Mahama Koné Aboudramane Koné Soleymane Collet Sylvain Diomandé Sekou Sissouma Drissa Department of Therapeutic Chemistry and Organic Chemistry UFR SPB FHB University Abidjan C&#244 te d’Ivoire Department of Chemistry UFR Environment Jean LorougnonGuédé University Daloa C&#244 te d’Ivoire Laboratory of Organic Chemistry and Natural Substances UFR SSMT FHB University Abidjan C&#244 te d’Ivoire Chemistry and Interdisciplinarity: Synthesis Analysis Modelling (CEISAM) University of Nantes Nantes France

The present pharmacochemical and modelling work focused on a benzimidazolyl-chalcone series. These previously synthesized compounds were evaluated in vitro for their anticancer activities against a panel of seven human cancer cell lines and normal fibroblasts. Among the new benzimidazole-supported chalcones, nine (9) compounds (compounds 1 - 4, 6 - 8 and compounds 10 and 11) showed promising anticancer activities with IC50s ranging from 0.83 to 2.58 μM. Compounds 2 and 6 with IC50s of 0.83 and 0.86 μM, respectively, were shown to be potent inhibitors of HCT-116 colon cancer cell proliferation. It was therefore necessary, for a development of this new series of chalcones, to establish through a QSAR study, their quantum descriptors according to the DFT calculation method and following the B3LYP/6-31+G (d,p) theory. These descriptive and predictive studies focused on the colon HCT 116 cell line which was found to be more sensitive to the anticancer action of our benzimidazolyl-retrochalcones. QSAR study showed that the electronic energy (Eelec), lipophilicity (logP), chemical softness (S) and chemical hardness (η) of benzimidazolyl-retrochalcones play an important role in inhibiting cancer cell proliferation.

关键词： Retrochalcone Benzimidazole anticancer agents QSAR Quantum Descriptors DFT Method

Rational design of multi-targeting ruthenium-and platinum-based anticancer complexes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2016年第10期59卷 1240-1249页

作者： Wei Zheng Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Analytical Chemistry for Living BiosystemsNational Centre for Mass Spectrometry in BeijingInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beo'ing 100049China

Platinum-based anticancer drugs, including cisplatin and its analogues, have played important roles in the clinical treatment of solid tumors over the past 38 years. However, poor selectivity, high toxicity and intrinsic or acquired drug resistance profoundly limit their application, which encourages the development of novel transition metal-based anticancer agents with different mechanisms of action. To this end, transition metal complexes that can simultaneously act on more than one target, termed as single-molecule multi-targeting complexes, have attracted increasing attention because of their enhanced efficacy and diminished chance of drug resistance. In this review, we systematically discuss the recent progress in the development of platinum- and ruthenium-based anticancer agents, in particular the rational design of platinum and ruthenium complexes with multi-targeting features.

关键词： anticancer agents metal complexes multi-targeting EGFR-inhibition DNA binding

Biological evaluation of 2-methylpyrimidine derivatives as active pan Bcr-Abl inhibitors

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2014年第6期57卷 823-832页

作者： ZOU DingBiao QIU YaTao TU ZhengChao LIAO ChenZhong LUO JinFeng MENG QingQing YAO RiSheng LI Zheng JIANG Sheng Laboratory of Medicinal Chemistry Guangzhou Institute of Biomedicine and HealthChinese Academy of Sciences School of Medical Engineering Hefei University of Technology Department of Radiology the Methodist Hospital Research Institute

We designed a series of 2-methylpyrimidine derivatives as new BCR-ABL inhibitors using scaffold-hopping *** synthetic compounds exhibited significant inhibition against a broad spectrum of Bcr-Abl mutants including the gatekeeper T315I *** 7u showed very potent kinase inhibitory activities against Bcr-Abl WT,Bcr-Abl E255K,Bcr-Abl Q252H,Bcr-Abl G250E and Bcr-Abl T315I,with IC50 values of 0.13 nM,0.17 nM,0.24 nM,0.19 nM and 0.65μM,*** compound also displayed anti-proliferation activity against K562 cell line with an IC50 value of 1.1 nM,thus representing a new lead for further optimization.

关键词： chronic myeloid leukemia(CML) anticancer agents Bcr-Abl imatinib resistance

A Systematic Review of anticancer Effects of Radix Astragali

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2016年第3期22卷 225-236页

作者： Yeehong Jung Uimin Jerng Sookyung Lee Department of Clinical Oncology College of Korean MedicineKyung Hee University Hospital at Gangdong Clinical Research Division Korea Institute of Oriental Medicine

Objective： To review the anticancer effects of Radix astragali （RA）, one of the most commonly used herbs to manage cancer in East Asia, and its constituents and to provide evidence of clinical usage through previously performed clinical studies. Methods： Preclinical and clinical studies related to the anticancer effects of RA were searched from inception to November 2013 in electronic databases. Two reviewers independently investigated 92 eligible studies, extracted all the data of studies and appraised methodological quality of clinical trials. The studies were categorized into in vitro and in vivo experimental studies and clinical studies, and analyzed by saponins, polysaccharides, and flavonoids of RA constituents, RA fraction, and whole extract. Results： In preclinical studies, RA was reported to have tumor growth inhibitory effects, immunomodulatory effects, and attenuating adverse effects by cytotoxic agents as well as chemopreventive effects. Saponins seemed to be the main constituents, which directly contributed to suppression of tumor growth through the activation of both intrinsic and extrinsic apoptotic pathway, modulation of intracellular signaling pathway, and inhibition of invasion and angiogenesis. Flavonoids suppressed tumor growth through the similar mechanisms with saponins. Polysaccharides showed immunomodulatory effects, contributing tumor shrinkages in animal models, despite the low cytotoxicity to cancer cells. Most of the clinical studies were performed with low evidence level of study designs because of various limitations. RA whole extracts and polysacchaddes of RA were reported to improve the quality of life and ameliorate myelosuppression and other adverse events induced by cytotoxic therapies. Coaclusion： The polysaccharides, saponins, and flavonoids of RA, and the whole extract of RA have been widely reported with their anticancer effects in preclinical studies and showed a potential application as a adjunctive cancer therapeutics with t

关键词： Radix astragali anticancer agents cancer systematic review

The Role of Chinese Medicine in Clinical Oncology

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2014年第1期20卷 3-10页

作者：孙燕 The Cancer Institute and Hospital Chinese Academy of Medical Sciences

Chinese Medicine（CM）has been used for several thousand years,playing an important role in the prevention and treatment of diseases including *** the recent four decades,a number of CM herbs have aroused extreme interest in the world-isolating anticancer components from medicinal herbs,using them as biological response modifiers,and most recently as angiogenesis *** present review reports both the experimental and clinical results obtained in the field of clinical oncology,especially conducted by our *** review also presents the possible future of integration of CM and modern medicine in basic research and clinical practice,especially when CM used as adjuvant and maintenance therapy.

关键词： Chinese medicine clinical oncology anticancer agents Fu-zheng therapy angiogenesis inhibitor