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Triple-synergistic MOF-nanozyme for efficient antibacterial treatment

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Bioactive Materials 2022年第11期7卷 289-299页

作者： Muxue Wang Xi Zhou Yunhong Li Yuqing Dong Jiashen Meng Shuai Zhang Linbo Xia Zhaozhi He Lei Ren Zhiwei Chen Xingcai Zhang Department of Electronic Science Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance ResearchSchool of Electronic Science and EngineeringXiamen UniversityXiamen361005People’s Republic of China The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province Research Center of Biomedical Engineering of XiamenDepartment of BiomaterialsCollege of MaterialsXiamen UniversityXiamen361005People’s Republic of China John A Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA02138USA School of Engineering Massachusetts Institute of TechnologyCambridgeMA02139USA

The abuse of antibiotics makes bacterial infection an increasingly serious global health threat. Reactive oxygen species (ROS) are the ideal alternative antibacterial approach for quick and effective sterilization. Although various antibacterial strategies based on ROS have been developed, many of them are still limited by insufficient antibacterial efficiency. Here, we have developed an acid-enhanced dual-modal antibacterial strategy based on zeolitic imidazolate frameworks-8 (ZIF8) -derived nanozyme. ZIF8, which can release Zn2+, is chosen as the carrier to integrate glucose oxidase (GOx) and gold nanoparticles (Au NPs) which can produce ROS via a cascade catalytic reaction. Thus, the bactericidal capability of ROS and Zn2+ have been integrated. More importantly, gluconic acid, a “by-product” of the catalytic reaction, can generate an acidic environment to promote both the ROS-producing and Zn2+-releasing, enhancing the overall antibacterial performance further. This triple-synergistic strategy exhibits extraordinary bactericidal ability at a low dosage of 4 μg/mL (for S. aureus) and 8 μg/mL (for E. coli), which shows a great potential of MOF-derived nanozyme for efficient bacterial eradication and diverse biomedical applications.

关键词： Metal-organic frameworks Nanozyme Reactive oxygen species antibacterial Zinc ion

Controllable oxygen vacancies and morphology engineering:Ultra-high HER/OER activity under base–acid conditions and outstanding antibacterial properties

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Journal of Energy Chemistry 2022年第8期31卷 639-651,I0017页

作者： Hongyao Xue Alan Meng Tongqing Yang Zhenjiang Li Chunjun Chen College of Electromechanical Engineering Qingdao University of Science and TechnologyQingdao 266061ShandongChina Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science MOECollege of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266061ShandongChina Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Colloid and Interface and ThermodynamicsCAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of Sciences 2Beijing 100190China School of Chemistry and Chemical Engineering University of Chinese Academy of SciencesBejing 100049China

Introducing vacancy defects and unique morphology is an effective strategy to improve the catalytic performance of transition metal compounds.However,precisely controlling the amount of vacancy defects remains challenging.Here,we propose a facile and efficient hydrothermal accompanying an annealing method to synthesize a series of Mn-doped CoO nanomaterials with controllable oxygen vacancies and unique morphology.The oxygen vacancies amount can be precisely controlled by adjusting the Mndoping content and is positively correlated with catalytic performance.It was found that the oxygen vacancies amount can reach up to 38.2%over the Mn-doped CoO nanomaterials,resulting in ultra-high hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)catalytic activity(HER:25.6 and 37 m V at 10 m A cm^(-2);OER:301 and 322 m V at 50 m A cm^(-2))under both basic and acidic conditions,while reaching 10 m A cm^(-2) for an ultra-low cell voltage of only 1.52 V,which exceeds that of Pt/C/RuO_(2) and all reported non-noble metal oxide catalysts.The DFT calculations reveal oxygen vacancies can optimize H*and HOO*intermediates adsorption free energy,thus improving the HER and OER performance.Interestingly,the Mn-doped CoO with rich oxygen vacancies exhibits excellent antibacterial properties in vitro of biomedicine.This work provides new ideas and methods for the rational design and precise control of vacancy defects in transition metal compounds and explores their potential application value in electrochemical water splitting and biomedical fields.

关键词： Oxygen vacancies Mn-doping HER OER antibacterial

Exploitation of the antibacterial,antibiofilm and antioxidant activities of Salvadora Persica(Miswak)extract

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Journal of Bioresources and Bioproducts 2023年第1期8卷 59-65页

作者： Gamal M.El-Sherbiny Ahmed Mohamed Gazelly Mohammed H.Sharaf Saad A.Moghannemm Shehata M.E Mahmoud K.A.Ismail Ahmad S.El-Hawary Botany and Microbiology Department Faculty of Science(Boys)Al-Azhar UniversityCairo 11884Egypt

The Salvadora persica(S.persica)L.chewing stick,usually known as miswak,is still being em-ployed as an oral hygiene agent for plaque and gingivitis prevention.This study aims to assess the antibacterial,antibiofilm,antioxidant,and phytochemical profile of S.persica extract.The S.per-sica was purchased from a local market,grinded and extracted with petroleum ether.The disk dif-fusion,microdilution,and micro-plate assays were performed to evaluate the antibacterial and an-tibiofilm activities of the prepared extract at different concentrations against𝛽-lactam resistance Streptococcus species.Free radical scavenging 2,2-diphenyl-1-picrylhydrazyl(DPPH)and stable radical cationic chromophore,2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonate)(ABTS)methods were used to determine their antioxidant activity.Chromatographic and spectrometric analyses were performed using gas chromatography-mass(GC-MS)spectrometry.The minimum inhibitory concentration(MIC)of S.persica extract against𝛽-lactam resistance Streptococcus species ranged from 6.25 to 12.5 mg/mL.The maximum suppression of biofilm formation by S.persica extract was observed at MIC with a percentage of 68.66%,against Streptococcus oralis.The S.persica ex-tract exhibited antioxidant activity with IC 50 of 20μg/mL and 35μg/mL from DPPH and ABTS,respectively.The phytochemical characterization showed the presence of 22 compounds with ma-jor compounds;benzyl isothiocyanate(36.21%)and n-hexadecanoic acid(27.62%).The S.persica extract exhibited antibacterial activity against𝛽-lactam resistant Streptococcus species,showing a promising natural alternative that could be a treatment option.

关键词： β-lactam resistance Streptococcus species S.persica extract antibacterial Antibiofilm Antioxidant GC-MS analysis

Preparation of dynamic polyurethane networks with UV-triggered photothermal self-healing properties based on hydrogen and ion bonds for antibacterial applications

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Journal of Materials Science & Technology 2023年第2期133卷 89-101页

作者： Huimeng Feng Wei Wang Tong Wang Lei Zhang Wen Li Jue Hou Shougang Chen School of Materials Science and Engineering Ocean University of ChinaQingdao 266100China

Photo-induced self-healing composites have attracted more and more attention as a kind of materials that can be controlled remotely and accurately in real time.Here,we report a strategy of a photo-responsive system based on hydrogen and ion bonds capable of performing self-healing process by ultraviolet wave-lengths,which is covalently cross-linked zinc-dimethylglyoxime-polyurethane coordination network with triple dynamic bonds.The recombination of hydrogen bond and metal coordination bond produces ef-fective healing performance.The self-healing behavior and temperature dependence of 3D micro-crack is investigated by molecular dynamics simulations to reveal the mechanism of self-healing at molecu-lar level.Moreover,the hybrid of copper-doped zinc oxide not only provides metal coordination bonds to enhance the self-healing rate,but also enhances the photothermal effect and anti-bacterial properties of polyurethane.Importantly,doping of copper generates more defects and forms a space charge layer on the surface of zinc oxide.The defects could trap surface electrons and holes,preventing the recom-bination of photo-induced electron-hole pairs,generating more heat through lattice vibration.Therefore,under ultraviolet light irradiation,the polyurethane can reach 62.7°C for 60 s,and the scratches of the polyurethane can be healed within 30 min and fully healed within 1 h.

关键词： Cu-dopped ZnO Ionic bond Photothermal Self-healing antibacterial

Biogenic synthesis of silver nanoparticles using Persicaria odorata leaf extract: antibacterial, cytocompatibility, and in vitro wound healing evaluation

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Particuology 2022年第11期70卷 10-19页

作者： Faridah Aminullah Lubis Nik Ahmad Nizam NikMalek Nor Suriani Sani Khairunadwa Jemon Department of Biosciences Faculty of ScienceUniversiti Teknologi Malaysia81310 UTMSkudaiJohorMalaysia Centre for Sustainable Nanomaterials(CSNano) Ibnu Sina Institute for Scientific and Industrial Research(ISI-ISIR)Universiti Teknologi Malaysia81310 UTMSkudaiJohorMalaysia Office of Deputy Vice Chancellor(Research and Innovation) Universiti Teknologi Malaysia81310 UTMSkudaiJohorMalaysia

Biogenic synthesis of silver nanoparticles(b-AgNPs)utilising plant extract has gained the interest of researchers due to the environmentally friendly and cost-effective technique.However,the extent of its application in the biomedical field remains scarce.This study evaluates the antibacterial,cytocompatibility,and wound healing activities of synthesised AgNPs using Persicaria odorata leaves extract(PO-AgNPs).The formation of PO-AgNPs was observed by visual colour changes and verified by ultraviolet-visible(UV–vis)spectrophotometer,which revealed a surface plasmon resonance(SPR)at around 440 nm,and further confirmed by X-ray diffraction(XRD).Characterisation using Fourier transform infrared(FTIR)spectroscopy showed biomolecules from the leaves extract presented together on PO-AgNPs.Field emission scanning electron microscope(FESEM)and high-resolution transmission electron microscopy(HR-TEM)images revealed PO-AgNPs nanospheres with diameters of 11±3 nm.Disc diffusion test(DDT)and minimum inhibitory concentration(MIC)analysis resulted in a dose-dependent inhibition of PO-AgNPs against tested Staphylococcus epidermidis and Methicillin-resistant Staphylococcus aureus(MRSA).These results were further corroborated by time-kill kinetic assay which revealed that PO-AgNPs were bactericidal against both strains 24 h post-treatment.Cytocompatibility and in vitro wound healing evaluation against normal human fibroblast cells,HSF 1184 inferred that PO-AgNPs are non-toxic to normal cells and able to enhance cell migration as compared to the non-treated cells.Therefore,PO-AgNPs are biocompatible and possess antibacterial and wound healing capabilities that are useful in biomedical applications.

关键词： Silver nanoparticles Biosynthesis antibacterial Cytocompatibility Wound healing

Mussel-inspired adhesive antioxidant antibacterial hemostatic composite hydrogel wound dressing via photo-polymerization for infected skin wound healing

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Bioactive Materials 2022年第2期7卷 341-354页

作者： Yutong Yang Yongping Liang Jueying Chen Xianglong Duan Baolin Guo Second Department of General Surgery Shaanxi Provincial People’s HospitalXi’an710068China Frontier Institute of Science and Technology and State Key Laboratory for Mechanical Behavior of Materialsand Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine ResearchCollege of StomatologyXi’an Jiaotong UniversityXi’an710049China Second Department of General Surgery Third Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710068China

With the increasing prevalence of drug-resistant bacterial infections and the slow healing of chronically infected wounds,the development of new antibacterial and accelerated wound healing dressings has become a serious challenge.In order to solve this problem,we developed photo-crosslinked multifunctional antibacterial adhesive anti-oxidant hemostatic hydrogel dressings based on polyethylene glycol monomethyl ether modified glycidyl methacrylate functionalized chitosan(CSG-PEG),methacrylamide dopamine(DMA)and zinc ion for disinfection of drug-resistant bacteria and promoting wound healing.The mechanical properties,rheological properties and morphology of hydrogels were characterized,and the biocompatibility of these hydrogels was studied through cell compatibility and blood compatibility tests.These hydrogels were tested for the in vitro blood-clotting ability of whole blood and showed good hemostatic ability in the mouse liver hemorrhage model and the mouse-tail amputation model.In addition,it has been confirmed that the multifunctional hydrogels have good inherent antibacterial properties against Methicillin-resistant Staphylococcus aureus(MRSA).In the full-thickness skin defect model infected with MRSA,the wound closure ratio,thickness of granulation tissue,number of collagen deposition,regeneration of blood vessels and hair follicles were measured.The inflammation-related cytokines(CD68)and angiogenesis-related cytokines(CD31)expressed during skin regeneration were studied.All results indicate that these multifunctional antibacterial adhesive hemostatic hydrogels have better healing effects than commercially available Tegaderm™Film,revealing that they have become promising alternative in the healing of infected wounds.

关键词： Chitosan Wound dressing antibacterial Wound healing Hemostat Infected skin wound

Copper ions-me diate d dynamic re dox-responsive microgels synergize with silicone for efficient and sustainable antibacterial properties

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Journal of Materials Science & Technology 2023年第12期143卷 253-267页

作者： Huali Li Liuqin Zhang Xiaohu Zhang Shuwen Luo Baoshan Yang Min Wu Wei-Hua Li Fa-Qian Liu School of Chemical Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China School of Materials Science and Engineering Sun Yat-sen UniversityGuangzhou 510275China Offshore Oil Production Plant of Sinopec Shengli Oilfield Company Dongying 257237China

The antifouling of marine facilities placed below the waterline is a key constraint to the development of the marine economy.Currently,commercial Cu_(2)O-based antifouling coatings still have defects such as agglomeration,oxidation,short duration and high dosage.For this reason,we developed for the first time a triple antifouling system consisting of Cu_(2)O@poly(NIPAM-co-DAm)(Cu_(2)O@PND)dynamic redox micro-gels triggered by copper ions and polydimethylsiloxane(PDMS).The catechol groups of PND nanogels can chelate Cu^(2+)and reduce it in situ to obtain Cu_(2)O@PND microgels,which guarantees the stable release of Cu^(+).Furthermore,Cu_(2)O remains stable and free from oxidation because of the electron transfer between PND and Cu^(2+).Finally,superior antifouling performance was achieved by combining the stable Cu^(+)re-leased from Cu_(2)O,in situ conversion of PND to hydrogel,and its oxidation to produce active substances and H_(2)O_(2),and PDMS coating with low surface energy.

关键词： Hydrogel Copper ions Dynamic redox Silicone Efficient-sustainable release antibacterial

Gallium containing bioactive materials: A review of anticancer, antibacterial, and osteogenic properties

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Bioactive Materials 2022年第11期7卷 125-146页

作者： Fatih Kurtuldu Nurshen Mutlu Aldo R.Boccaccini Dusan Galusek FunGlass Alexander Dubcek University of TrencínStudentska 291150TrencínSlovakia Institute of Biomaterials Department of Material Science and EngineeringUniversity of Erlangen-Nuremberg91058ErlangenGermany Joint Glass Centre of the IIC SAS TnUAD and FChFT STUStudentska 291150TrencínSlovakia

The incorporation of gallium into bioactive materials has been reported to enhance osteogenesis,to influence blood clotting,and to induce anti-cancer and anti-bacterial activity.Gallium-doped biomaterials prepared by various techniques include melt-derived and sol-gel-derived bioactive glasses,calcium phosphate bioceramics,metals and coatings.In this review,we summarize the recently reported developments in antibacterial,anti-cancer,osteogenesis,and hemostasis properties of Ga-doped biomaterials and briefly outline the mechanisms leading to Ga biological effects.The key finding is that gallium addition to biomaterials has great potential for treating bone-related diseases since it can be efficiently transferred to the desired region at a controllable rate.Besides,it can be used as a potential substitute for antibiotics for the inhibition of infections during the initial and advanced phases of the wound healing process.Ga is also used as an anticancer agent due to the increased concentration of gallium around excessive cell proliferation(tumor)sites.Moreover,we highlight the possibility to design different therapeutic approaches aimed at increasing the efficiency of the use of gallium containing bioactive materials for multifunctional applications.

关键词： antibacterial Bioactive materials Cancer treatment Hemostasis Osteogenesis

Boron doped graphdiyne:A metal-free peroxidase mimetic nanozyme for antibacterial application

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Nano Research 2022年第2期15卷 1446-1454页

作者： Xuelong Bi Qiang Bai Lina Wang Fanglin Du Manhong Liu William W.Yu Siheng Li Jiaqiang Li Zhiling Zhu Ning Sui Jin Zhang College of Materials Science and Engineering Qingdao University of Science and TechnologyQingdao 266042China Center for Natiochemistry Beijing Science and Engineering Center for NanocarbonsNational Laboratory for Molecular SciencesCollege ofChemistry and Molecular EngineeringPeking UniversityBeijing 100871China College of Environment and Safety Engineering Qingdao University of Science and TechnologyQingdao 266042China Department of Chemistry and Physics Louisiana State University ShreveportOne University PlaceShreveportLA 71115USA Department of Chemistry University of HoustonHoustonTX 77204USA

The abuse of conventional antibiotics leads to increasing bacterial resistance.Nanozyme is a new kind of ultra-efficient and safe nanomaterial with intrinsic enzyme-like activities,showing remarkable potential as a next generation nanobactericide.Graphdiyne(GDY)is a burgeoning two-dimensional(2D)carbon allotrope with intriguing physicochemical properties,holding a great promise as a metal-free nanozyme.In this study,a boron doped GDY nanosheet(B-GDY)was constructed to simulate the performance of peroxidase(POD).By promoting the decomposition of H_(2)O_(2) to produce reactive oxygen species(ROS),the bactericidal efficacies against both Gram-positive and Gram-negative bacteria were substantially enhanced attributed to the extremely high catalytic activity of B-GDY.In-depth density functional theory(DFT)calculations illuminate that doping of boron can introduce more active B-defect sites as well as lower Gibbs free energy during the H_(2)O_(2) decomposition reaction.Notably,B-GDY contributes to significant wound healing and excellent biocompatibility,reducing the biological burden.The design of this nanozyme opens a new avenue for the development of alternative antibiotics.

关键词： graphdiyne nanozyme metal-free antibacterial wound healing