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Particuology 2024年第1期84卷 126-135页

作者： Yanyan Huang Huimin Zhong Cong Jiang Jiahui Yang Jingwen Zhang Fei Zhao Chaoqun Liu College of Light Industry and Food Engineering Nanjing Forestry UniversityNanjing210037China College of Pharmacy Institutes of Environment and MedicineHenan UniversityKaifeng475004China

With natural polyphenol compound tannic acid(TA)as the ingredient,copper tannate(CuTA)nanolayer material was formed by self-assembly under the conditions of heating and copper *** ion and tannic acid could coordinate to form Cu-O-C structure which was similar to the Fe-N-C structure of natural heme *** addition,the obtained CuTA nanomaterial possessed excellent peroxidase-like catalytic activity and *** on this excellent enzymatic activity,CuTA nanomaterials could be used for colorimetric detection of hydrogen peroxide with a smartphone and decomposition of organic *** on the structural characteristics and catalytic activity,the copper tannate nanozymes could also serve as potential antibacterial reagents to effectively inhibit the growth of gram-negative and positive bacteria in a low hydrogen peroxide *** work may promote the exploration of novel peroxidase mimetics and broaden the applications of nanozymes.

关键词： Nanozyme Colorimetric detection Smartphone antibacteria

Treatment of colorectal cancer by anticancer and antibacterial effects of hemiprotonic phenanthroline-phenanthroline^(+) with nanomicelle delivery

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Asian Journal of Pharmaceutical Sciences 2023年第3期18卷 79-91页

作者： Yingying Zhang Zizhen Zhao Jingli Li Qinghua Wang Zhigang Fan Zhibo Yuan Yixiao Feng Ailing Fu College of Pharmaceutical Sciences Southwest UniversityChongqing 400716China

Colorectal cancer(CRC)is a common digestive tract tumor *** microorganisms,including Fusobacterium nucleatum(***)and Escherichia coli(***),are abundant in colonic mucosa and can promote the cancer progression and ***,a therapeutic strategy is proposed to deliver effective drugs to colorectum for both anticancer and *** we used thin-film dispersionmethod to encapsulate hemiprotonic phenanthroline-phenanthroline^(+)(ph-ph^(+))into *** results showed that the drug-loading nanomicelle had good dispersion,and the particle size was about 28 *** vitro assay indicated that the nanomicelle was active against CRC-related obligate and facultative *** human CRC cells,the nanomicelle could effectively inhibit cell proliferation and induce *** vivo distribution showed that the nanomicelle could release ph-ph^(+) mainly in the *** CRC model mice,the nanomicelle significantly reduced tumor number and volume,and decreased the bacteria load and colorectal ***,the study identifies that the ph-ph^(+) nanomicelle has the potential to apply in treating CRC,and also suggests that anticancer combined with antimicrobial therapy would be a feasible way for CRC therapy.

关键词： CRC Drug-loading nanomicelle antibacteria Inflammation

antibacterial Surface Treatment of Aluminum Materials

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Chinese Journal of Chemical Engineering 2002年第5期10卷 622-624页

作者：迟广俊姚素薇范君张卫国王宏智 School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China Changdian Hospital Anshan Steel and Iron Group Anshan 114000 China

Aluminum specimens were anodized in a sulfuric acid bath, thensilver was electrodeposited in pores of the anodized aluminum byusing alternating current. The anodized aluminum with depositedsilver was tested for its antibacterial performance. The results showthat the antibacterial rates of the specimens are above 95/100against the growth of E. coli, P. Aeruginasa, S. faecalis and ***. The morphology of the silver in pores of anodized aluminum ischaracterized by transmission electron microscopy, and themicrographs indicate that silver is assembled in the form ofnanowires with a diameter of 10 nm or 25 nm. The nanowires have astructure of parallel bright stripes alternating with parallel darkstripes.

关键词： electrodeposition antibacteria aluminum anodic oxide nanwires

antibacterial Effects of Silver Loaded Hydroxyapatite

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Tsinghua Science and Technology 1999年第3期4卷 1570-1573页

作者：赵锴冯庆玲陈国强 Department of Biological Sciences and Biotechnology Tsinghua University Beijing 100084 Department of Materials Science and Engineering Tsinghua University Beijing 100084 Department of Materials Science and Engineering Tsinghua University Beijing 100084

The antibacterial capability of silver loaded hydroxyapatite(HA\|Ag) in both poor nutrient phosphate buffer saline solution(PBS,pH=7.4)and nutrient rich medium,which represented two kinds of typical conditions in real life,was evaluated respectively using Escherichia coli as a *** 0 4?mg/mL in PBS solution containing an initial cell concentration of 10\+6/mL,HA\|Ag killed all the *** cells in the PBS solution within 4 5?h .In a nutrient rich medium containing a cell concentration of 10\+7/mL,HA\|Ag exhibited a remarkable inhibitory effect of *** *** maximum specific growth rate in the medium containing 3?mg/mL HA\|Ag was only 0 292, 26% of that in a control sample which was 1 116,and the viable cell concentration in the former HA\|Ag medium was just 40% of that in the *** a safe antibacterial agent,HA\|Ag powder demonstrated antibacterial efforts both in poor nutrient and in nutrient rich *** seems that the HA\|Ag compound hold a lot of promises for practical applications.

关键词： silver hydroxyapatite E.coli antibacteria

Isolation, characterization and chromatography based purification of antibacterial compound isolated from rare endophytic actinomycetes Micrococcus yunnanensis

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Journal of Pharmaceutical Analysis 2017年第5期7卷 343-347页

作者： Ravi Ranjan Vasantba Jadeja Department of Biotechnology Shree M.& N.Virani Science College Department of Microbiology Shree M.& N.Virani Science College

Endophytic actinomycetes are considered as one of the relatively unexplored potential sources in search of antibiotic producer against antibiotic resistant pathogens. A potent strain isolated from Catharanthus roseus that displays antibacterial potential against antibiotic resistant human pathogen Staphylococcus aureus was characterized and designated as Micrococcus yunnanensis strain rsk5. Rsk5 is capable of producing optimum antibacterial metabolites on starch casein medium at 30 °C, p H 5 and 2% Na Cl condition. The crude antibacterial agent was extracted from fermentation broth by ethyl acetate and separated by TLC using chloroform-methanol(24:1, v/v) solvent system with R f value of 0.26. It was partially purified by flash chromatography, followed by HPLC and analyzed by ultraviolet visible spectrophotometer to get absorption maxima at 208.4 nm. The ESI-MS spectra showed molecular ion peaks at m/z 472.4 [M-H], which does not match with any known antibacterial compound.

关键词： Micrococcus yunnanensis strain rsk5 Catharanthus roseus Endophytes antibacteria Chromatography

Potency of Nannochloropsis oculata as antibacterial, Antioxidant and Antiviral on Humpback Grouper Infected by Vibrio alginolyticus and Viral Nervous Necrotic

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Journal of Food Science and Engineering 2011年第5期1卷 323-330页

The aim of this study was to explore the potency of N. oculata extracts as antibacterial, antioxidant and antiviral on grouper Cromileptes altivelis （C. altivelis） infected by Vibrio alginolyticus （V. alginolyticus） and Viral Nervous Necrotic （VNN）. Dilution test was used to measure antibacterial activity of N. oculata extracts. Antioxidant activity of extracts was expressed by levels of MDA （Malondialdehyde） and SOD （superoxide dismutase） in the brain and kidneys of fish. Antiviral capability of N. oculata was determined by the expression of cellular immune cells Major Histocompatibility Complex （MHC） Class I for proliferation and inhibition of VNN in blood cells with immunocytochemistry. The results showed that N. oculata extract was able to suppress the growth of V. alginolyticus at a concentration of 40%. Increasing levels of SOD and reducing level of MDA indicated that N. oculata extracts may serve as an antibacterial and antioxidant. Providing cellular response of MHC class I cell expressed on C. altive/is blood cells, N. oculata demonstrated its antiviral activity.

关键词： antibacteria antioxidant antiviral C. altivelis N. oculata.

Metal-based inorganic nanocrystals for biological sonodynamic therapy applications:recent progress and perspectives

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Rare Metals 2024年第2期43卷 413-430页

作者： Dong Wang Jia-Tao Zhang Institute of Medical-Industrial Integration Beijing Key Laboratory of Structurally Controllable Advanced Functional Materials and Green ApplicationsSchool of Materials Science and EngineeringBeijing Institute of TechnologyBeijing100081China Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering Ministry of Industry and Information TechnologySchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing100081China

With the fast development of technology for the treatment of tumor and bacteria,photo-therapeutic strate-gies emerge as a kind of highly effective and common treatment,but the low tissue penetration depth of light limits their *** therapy(SDT),as an efficient and non-invasive treatment,attracts more people's attention due to the inherent property of high tissue *** soft tissue penetration depth of ultrasound(US)can even reach more than 10 cm,which has great advantage over that of ***,many sonosensitizers are studied and applied to SDT-based ***-based inorganic nanocrystals are able to generate more reactive oxygen species(ROS)due to the special composition and band *** representative achievements and the specific functions of the nanocrystals sonosensitizers are summarized in this work,and the relationship of structure/composition-SDT performance and the internally regulated composite is ***-gistic effects of SDT in combination with other therapeutic modalities are mainly *** the same time,the critical and potential issues and future perspectives are addressed.

关键词： Metal-based inorganic nanocrystals Sonodynamic therapy(SDT) Tumor treatment antibacteria

antibacterial Performance of Protective and Decorative Deposits

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Transactions of Tianjin University 2002年第3期8卷 156-158页

作者：迟广俊姚素薇张卫国王宏智范君任光勋天津大学化工学院天津300072 鞍山钢铁集团公司长甸医院辽宁鞍山114000

By way of bactericidal halo test, the antibacterial performance of various electroplated deposits (cobalt, zinc, copper, silver, gold, nickel, chromium, cobalt-containing alloy of nickel, and nickel-containing alloy of cobalt) were determined. The results of the test show that the electroplated deposits of zinc, cobalt, cobalt-containing alloy of nickel, and nickel-containing alloy of cobalt, silver and copper possess a distinct antibacterial capability against the growth of pathogenic bacteria tested, and that SUS304 stainless steel and chromium deposit have no antibacterial activity. The relationship between the antibacterial capability and the rest potentials of the deposits was investigated. It was found that the higher the antibacterial activity of the electroplated deposit was, the more negative the rest potential of deposit was.

关键词： electrodeposition bactericidal halo test antibacteria

Photoelectric-driven conductive composite ionogel patch for effective wound healing

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eScience 2024年第2期4卷 92-100页

作者： Xingkai Ju Jiao Kong Guohua Qi Shuping Hou Bo Wang Xingkang Diao Shaojun Dong Yongdong Jin State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China Guangdong Key Laboratory of Biomedical Measurements and Ultrasound Imaging School of Biomedical EngineeringShenzhen University Medical SchoolShenzhen UniversityShenzhen 518060China

Developing the high biosafety,effective and wearable devices for fast wound healing is highly desired but remains a ***,we propose a“win–win co-operation”strategy to potentiate effective skin wound healing at the wound site by constructing robust and ecofriendly composite patch under opto-electric *** wearable patch is composed of ionic gel doped with Ti3C2Tx(MXene),which possesses good photothermal response to kill the bacteria via effective inhibition of the expression of inflammatory factors,preventing wound ***,the composite ionogel patch is capable of providing green and on-demand electrical stimulation for wound site,guiding cell migration and proliferation by improved bioenergy and expression up-regulation of growth *** mice wound models,the treatment group healed~31%more ***,the wearable devices could enable visual and real-time supervising treatment effect due to their good *** proposed strategy would be promising for future clinical treatment of wound healing.

关键词： Wound healing Wearable composite ionogel patch antibacteria Electrical stimulation Cell migration and proliferation

Elaborately engineered Au(I)-based AIEgens: Robust and broad-spectrum elimination abilities toward drug-resistant bacteria

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Aggregate 2024年第5期5卷 274-286页

作者： Shuangling Deng Zhen Peng Fang Zhou Guanqing Zhong Zhen Cai Xiaodong Tang Changhuo Xu Lei Zheng Ben Zhong Tang Jing Zhang Department of Laboratory Medicine Nanfang HospitalSouthern Medical UniversityGuangzhouChina National Key Laboratory of Green Pesticide College of ChemistryCentral China Normal UniversityWuhanChina Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhouChina MOE Frontiers Science Center for Precision Oncology Faculty of Health SciencesUniversity of MacaoTaipaMacaoChina School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhenGuangdongChina

Antimicrobial resistance(AMR)remains an urgent and formidable challenge to global public *** new medicines or alternative therapies to address AMR is ***,we rationally designed and synthesized a series of Au(I)-based aggregation-induced emission luminogens(AIEgens)to combat drug-resistant bacterial *** systematic screening,we identiﬁed an optimal AIEgen,called complex 5,which can rapidly discriminate between gram-positive(G^(+))and gram-negative bacteria(G^(-))bacteria,and exert robust and broad-spectrum antimicrobial potency against diverse drug-resistant bacterial strains,including those intractable to treat in ***,extensive testing against a variety of clinical drug-resistant isolates,coupled with the successful treatment of methicillin-resistant Staphylococcus aureus-infected skin wounds unequivocally validates the high efﬁciency and broad-spectrum activity of complex ***,complex 5 emerges as a promising candidate for combating drug-resistant bacterial infections in clinic,and this work provides inspiration for developing new solutions to address the escalating global challenge of AMR.

关键词： aggregation-induced emission antibacteria gold(I)complex phototherapy