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anti-virus prophylaxis withdrawal may be feasible in liver transplant recipients whose serum HBeAg and HBV DNA are negative

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Hepatobiliary & Pancreatic Diseases International 2016年第3期15卷 316-318页

作者： Lei Geng Bing-Yi Lin Tian Shen Hua Guo Yu-Fu Ye Shu-Sen Zheng Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryFirst Affiliated HospitalZhejiang University School of Medicine Key Laboratory of Combined Multi-organ Transplantation Ministry of Public HealthKey Laboratory of Organ Transplantation and Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases

anti-virus prophylactic therapy may be not nec- essary for the prevention of hepatitis B virus （HBV） recur- rence after HBV-related liver transplantation （LT）. However, studies on completely stopping the hepatitis B immune globu- lin （HBIG） and nucleos（t）ide analogs （NUC） after LT are few. The aim of the current study was to evaluate the safety of anti- virus prophylaxis withdrawal in liver recipients whose serum hepatitis B e antigen （HBeAg） and HBV DNA are negative. We analyzed 190 patients undergone LT for HBV-related liver dis- ease from 2006 to 2012 and found that 10 patients completely stopped the HBIG and NUC due to poor compliance. These patients were liver biopsied and checked monthly with serum HBV markers, HBV DNA and liver function. Among the 10 patients, 9 did not show the signs of HBV recurrence after a mean follow-up of 51.6 months （range 20-73） after with- drawal of the HBIG and NUC. The average time from LT to the withdrawal of the anti-virus drug was 23.8 （13-42） months; one patient showed hepatitis B surface antigen-positive and detectable HBV DNA after stopping anti-virus drugs and this patient was successfully treated with entecavir. Our data sug- gested that complete withdrawal of anti-virus prophylaxis was safe and feasible for patients whose serum HBeAg and HBV DNA were negative at the time of LT.

关键词： anti-virus prophylaxis withdrawal HBeAg HBV DNA liver transplantation

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