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In vitro assessment of antioxidant,neuroprotective,anti-urease and anti-tyrosinase capacities of Tamarix africana leaves extracts

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Journal of Traditional Chinese Medicine 2023年第2期43卷 252-264页

作者： Esma Anissa Trad Khodja Abd El Hamid Khabtane Rabah Arhab Djamila Benouchenne Mohamed Sabri Bensaad Chawki Bensouici Ramazan Erenler Biotechnology WaterEnvironment and Health LaboratoryFaculty of Natural and Life SciencesUniversity Abbes LaghrourKhenchela 40000Algeria Laboratory of Natural Substances Biomolecules and Biotechnological ApplicationsFaculty of Natural and Life SciencesUniversity Larbi Ben M HidiOum El-Bouaghi 04000Algeria Genetics Biochemistry and Plant Biotechnology LaboratoryFaculty of Natural and Life SciencesUniversity Constantine 1Constantine 25000Algeria Pharmaceutical Sciences Research Center Constantine 25000Algeria Laboratory of Cellular and Molecular Physio-Toxicology-Pathology and Biomolecules(LPTPCMB) Faculty of Natural and Life SciencesUniversity Batna 2Batna 05000Algeria Laboratory of Biotechnology of Bioactive Molecules and Cellular Physiopathology(LBMBPC) Faculty of Natural and Life Sciences University Batna 2Batna 05000Algeria Biotechnology Research Center Ali Mendjli UV 03 Constantine 25000Algeria Department of Chemistry Faculty of Science and LiteratureUniversity TokatGaziosmanpasaTokat 60250Turkey

OBJECTIVE:To characterize the chemical profile of methanolic crude extract and its fractions(Ethyl acetate,n-butanol and aqueous)using liquid chromatographymass spectrometry(LC-MS)analysis,to evaluate their biological and pharmacological properties:antioxidant(1,1-diphenyl-2-pycrylhydrazyl(DPPH),2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic)(ABTS·+),galvinoxyle free radical scavenging,reducing power,phenanthroline andβcarotene-linoleic acid bleaching assays),enzymes inhibitory ability against several enzymes[acetylcholinesterase(AChE),buthyrylcholinesterase(BChE),urease and tyrosinase].METHODS:Secondary metabolites were extracted from Tamarix africana air-dried powdered leaves by maceration,the crude extract was fractionated using different solvents with different polarities(Ethyl acetate,n-butanol and aqueous).The amount of polyphenols,flavonoids and tannins(hydrolysable and condensed)were determined using colorimetric assays.A variety of in vitro biochemical tests were carried out to assess antioxidant and oxygen radical scavenging properties using DPPH,ABTS,galvinoxyle free radical scavenging,reducing power,phenanthroline andβcarotene-linoleic acid bleaching *** effect was examined against acetylcholinesterase and buthyrylcholinesterase *** anti-urease and antityrosinase activities were performed against urease and tyrosinase enzymes *** extract’s components were identified using LC-MS and compared to reference ***:The results indicated that Tamarix africana extracts presented a powerful antioxidant activity in all assays and exhibited a potent inhibitory effect against AChE and BChE as well as urease and tyrosinase ***-MS analysis identified amount of eight phenolic compounds were revealed in this analysis;Apigenin,Diosmin,Quercetin,Quercetine-3-glycoside,Apigenin 7-O glycoside,Rutin,Neohesperidin and Wogonin in methanolic extract and its different fractions of Tamarix africana from ***

关键词： antioxidants anti-tyrosinase anti-urease liquid chromatography-mass spectrometry neuroprotection phenolic content Tamarix africana

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The phytochemical,proximate,pharmacological,GC-MS analysis of Cyperus esculentus(Tiger nut):A fully validated approach in health,food and nutrition

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Food Bioscience 2022年第2期46卷 346-355页

作者： Laurine Chikodiri Nwosu Great Iruoghene Edo Erkay Ozgor Faculty of Health Sciences Department of Health Care Organizations ManagementCyprus International UniversityNicosiaTurkey Faculty of Arts and Sciences Department of ChemistryCyprus International UniversityNicosiaTurkey Faculty of Arts and Sciences Department of Molecular Biology and GeneticsCyprus International UniversityNicosiaTurkey

Cyperus esculentus(Tiger nut)has been grossly underutilized and unexploited despite its nutritional and medicinal *** research aimed to evaluate the phytochemical,proximate,GC-MS and pharmacological properties such as antioxidant,anticancer,anti-elastase,anti-melanogenic and anti-tyrosinase activity in ethanol and n-hexane extracts of tiger *** pharmacological activities were measured using spectrophotometry,agar well diffusion,MCF-7 and HeLa cell *** tiger nut extracts(ethanol and n-hexane)in the phytochemical and proximate analysis showed the existence of bioactive compounds such as alkaloids,glycosides,flavonoids,crude fibres,tannins,proteins,carbohydrates,oxalates,phytates and fats *** ethanol extract showed superior pharmacological(anticancer,antibacterial,anti-melanogenic and antioxidant)activities,especially against the MCF-7 cell *** results for scavenging activity of ethanol extract(IC_(50)=535.57μg/mL)showed significant differences(p<0.05)when compared with n-hexane extract(IC_(50)=645.5μg/mL).The GC-MS assessment of both extracts showed the existence of bioactive *** concentrations(100,200 and 350 mg/mL)of tiger nut extracts against Shigella sp.,Salmonella sp.,Staphylococcus aureus and Escherichia coli demonstrated the highest level of inhibitions at 350 mg/*** findings of the current research showed that tiger nut has a high content of nutrients and bioactive phytochemicals.

关键词： Tiger nut anti-elastase anti-tyrosinase anti-cancer antibacterial anti-melanogenic

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Synthesis of prenylated and geranylated xanthones and their bioactivities

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Journal of Chinese Pharmaceutical Sciences 2020年第8期29卷 564-576页

作者： Beidou Zhou Zihan Yu Yugui Tong Jiali Li Baocheng Huang Rongrong Wei Zhimin Weng Xin Wang Zhipeng Ruan Jian Lin Caihong Xu Jianbo Liu School of Pharmacy and Medical Technology Putian UniversityKey Laboratory of Pharmaceutical Analysis and Laboratory Medicine(Putian University)Fujian Province UniversityPutian 351100China Putian Entry-exit Inspection and Quarantine Bureau Putian 351100China The Affiliated Hospital(Group)of Putian University Putian 351100China Lianhe Chemical Technology Co. Ltd.Taizhou 318020China

Nine prenylated and geranylated xanthones were synthesized in two steps with total yields ranging from 11%to 36%.All of the compounds were first ***,the antitumor,anti-tyrosinase,anti-pancreatic lipase,antifungal and antibacterial activities of all or part of compounds 1–9 were *** 9 exhibited clear antitumor activity,and its cytotoxicity against MCF-7 and MDA-MB-231 cells was stronger compared with *** 1–4 and 6–7 also exhibited certain activity other than the antitumor activity described *** results demonstrated that compounds 1–4,6–7 and 9 were very promising leads for further structural modification.

关键词： Xanthone antitumor activity anti-tyrosinase antifungal activity antibacterial activity

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Syntheses of phenyl benzoate compounds and their bioactivity investigation

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Journal of Chinese Pharmaceutical Sciences 2021年第11期30卷 874-882页

作者： Beidou Zhou Jiali Li Baocheng Huang Zihan Yu Zetong Ma Zhipeng Ruan Qihong Cai Dongbao Hu School of Pharmacy and Medical Technology Putian UniversityKey Laboratory of Pharmaceutical Analysis and Laboratory Medicine(Putian University)Fujian Province UniversityKey Laboratory of Medical Microecology(Putian University)Fujian Province UniversityPutian UniversityPutian 351100China School of Chemical Biology and Environment Yuxi Normal UniversityYuxi 653100China

Eight phenyl benzoate compounds were synthesized in one step, and then their antioxidant, anti-tyrosinase, and anti-pancreatic lipase activities were evaluated in the present study. The total yields ranged from 31% to 85%. Compound 4 c exhibited a stronger antioxidant activity compared with Trolox, with half maximal inhibitory concentrations(IC50) of approximately 13.06 μM, and the antioxidant mechanism was further studied using computational chemistry. Compounds 1 c–5 c exhibited minimal anti-tyrosinase activity. Compounds 4 c, 5 d, 6 c and 6 d exhibited weak anti-pancreatic lipase activity, with an inhibition rate of 33.52%, 15.76%, 18.37% and 20.77%, respectively. These results demonstrated that all compounds had reference significance, especially compound 4 c.

关键词： Phenyl benzoate Synthesis antioxidant anti-tyrosinase anti-pancreatic lipase

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Inhibition kinetics and molecular simulation of guanidine analogues on tyrosinase

Inhibition kinetics and molecular simulation of guanidine an...

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华东地区生物化学与分子生物学学会联合会2017年学术交流会暨安徽省生物化学与分子生物学学会理事会议

作者： Wei-Chao Su Yu-Xia Wang Yu-Feng Lin Yan-Mei Chen Qing-Xi Chen State Key Laboratory of Cellular Stress Biology School of Life SciencesXiamen University

tyrosinase(EC 1.***.18.1) is a copper-containing,mixed function oxidase widely distributed in animals,plants,and *** catalyzes two distinct reactions of melanin biosynthesis by hydroxylation of monophenols to o-diphenols and oxidation of o-diphenols to the corresponding o-quinones,which are the initial steps whereafter a series of highly reactive quinones are produced to initiate the pigmentation and excessive activation of tyrosinase can cause various dermatological *** antityrosinase and antioxidant activity of guanidine analogues(guanylthiourea,guanidine thiocyanate,phenethyldiguanide) have been *** results showed that three compounds can reduce both monophenolase and diphenolase activity on tyrosinase,and the inhibition was *** IC50 values of guanylthiourea,guanidine thiocyanate and phenethyldiguanide were 0.075,0.140 and 0.440 mM on monophenolase and 0.495,3.694 and 3.222 mM on diphenolase,*** the diphenolase activity,these analogues were found to be reversible inhibitors of the ***,guanylthiourea and phenethyldiguanide were found to be competitive inhibitors while guanidine thiocyanate is mixed-type *** molecular mechanism underlying the inhibition of tyrosinse by guanidine analogues was detected by means of UV-scanning study,fluorescence quenching and molecular docking *** results showed that the analogues could decrease the formation of *** all the analogues were static quenchers of mushroom *** docking results showed that guanidine thiocyanate and phenethyldiguanide were less active than guanylthiourea against mushroom tyrosinase because of theirs weaker interaction with the dicopper irons in the enzyme active *** antioxidant activity was investigated by FRAP,ABTS,DPPH and DNA damage protection,which revealed that guanylthiourea possessed potent antioxidant activity *** research contributed to the usage of guanidine anal

关键词： guanidine analogues anti-tyrosinase antioxidant fluorescence quenching molecular simulation

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