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anti-spermatogenic Effects of Ethanol Extract of Mucuna Urens

Journal of Reproduction and Contraception 2009年第3期20卷 161-168页

作者： Hannah Edim Etta Udoh Paul Bassey Eneobong Effiom Eneobong Okon Bassey Okon Biological Science Department Cross River University of Technology Environmental Biology and Zoology Department University of Calabar Genetics and Biotechnology Department University of Calabar Animal Science Department Faculty of AgricultureUniversity of Calabar

Objective To investigate the age-long claim by the locales that the food thickener, M. urens seed, has antispermatogenic, hence, antifertility effects in man. Methods Eight-week old male Albino rats were used as the mammalian model for this study. They were assigned to four groups of 6 rats each and treatment with the ethanol extract was for a period of 14 d. The treatment regimes were 70 mg/kg, 140 mg/kg, 210 mg/kg and 0 mg/kg BW in groups A, B, C and D, respectively. Extracts were prepared by Soxhlet extraction using 80% ethanol as the extracting solvent. The stock solution was prepared by dissolving 1 g of the paste extract in 10 ml corn oil （vehicle） to make up 100 mg/ml concentration. At the end of the treatment, sperm from the distal caudal epididymis was collected and analyzed for sperm count, sperm motility and sperm morphology. Results Significant reduction was observed in sperm count and sperm motility （P〈0.05）. The mean sperm count for group A was 6.27±0.02×10^6, for group B was 6.16±0.02×10^6 and group C had 6.0±0.0×10^6 sperm cells The control （group D） had a mean sperm count of 6.50±0.09×10^6 which was higher than that of any treated group. Results of the sperm motility test gave the following mean rates for motile sperm cells after treatment： group A, 57.6±% 2.1; group B, 50.0±4.0; group C, 45.0±4.0. The control had the highest mean motility rate of 72.3±2.1. The observed sperm abnormalities included unusual head with large acrosome, looped tailpiece, mid piece with distal droplet, pin head, pyriform head and long *** The anti-spermatogenic effects of the extract on the sperm in the Albino rat may lead to reduction of fertility.

关键词： Mucuna urens anti-spermatogenic sperm count sperm motility sperm morphology

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antifertility effects of 60-day oral gavage of ethanol extract of Spondias mombin leaves in guinea pigs: A biochemical, reproductive and histological study

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Asian pacific Journal of Reproduction 2021年第2期10卷 56-67页

作者： Olalekan Bukunmi Ogunro Musa Toyin Yakubu Phytomedicine ToxicologyReproductive and Developmental Biochemistry Research LaboratoryDepartment of BiochemistryUniversity of IlorinIlorinNigeria Department of Biological Sciences KolaDaisi UniversityIbadanOyo StateNigeria

Objective:To investigate the impact of ethanol extract of Spondias(S.)mombin leaves on the biochemical parameters of testicular function,hormonal profile,sperm profile and reproductive outcomes of guinea ***:Sexually matured male[(1000.40±8.12)g]and female[(810.00±7.09)g]guinea pigs were *** testicular function study,a total of 24 male guinea pigs were randomised into 4 groups of 6 guinea pigs *** A(control)was orally administered 1 mL of physiological saline,once daily for 60 days while groups B,C and D were treated like the control group except that they were orally administered 100,250 and 500 mg/kg body weight of ethanol extract of *** *** the fertility study,the same animal groupings and treatments in the testicular function study were *** male guinea pigs were paired with the females(1:1)and afterwards examined for pregnancy ***:The ethanol extract of *** leaves contained saponins,alkaloids,flavonoids,tannins,steroids,phenolics,phlobatannins,cardiac glycosides,cardenolides and dienolides with saponins(4.80 mg/mL)occurring the most whilst cardenolides and dienolides(0.08 mg/mL)were the *** ethanol extract of *** leaves significantly and dose dependently reduced the activities of alkaline phosphatase,glutamate dehydrogenase,3-hydroxy-3-methylglutaryl coenzyme A reductase,malic enzyme,17-β-hydroxysteroid dehydrogenase,lactate dehydrogenase,catalase and superoxide dismutase as well as levels of testosterone,glycogen,total protein and ascorbic acid in the testes when compared with the control group(P<0.05).All the doses of ethanol extract of *** leaves also reduced the levels of sorbitol dehydrogenase,3-β-hydroxysteroid dehydrogenase,glucose-6-phosphate dehydrogenase and sialic acid whereas the levels of testicular acid phosphatase,gamma glutamyl transferase and cholesterol increased dose dependently(P<0.05).The serum luteinising hormone,testosterone and estradiol were reduced after the admin

关键词： Anacardiaceae Spondias mombin Guinea pig Testicular dysfunction anti-spermatogenic antifertility

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