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A New Compound with anti-oxidative activity from Seeds of Jatropha curcas

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Chinese Herbal Medicines 2010年第4期2卷 245-247页

作者： LI Ling1, 2, WANG Xin-luan1, LI Xiao-fan2, WANG Nai-li1, 2 1. College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China 2. Key Laboratory for New Drugs Research of Traditional Chinese Medicine in Shenzhen, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, China College of Traditional Chinese Materia Medica. Shenyang Pharmaceutical University Shenyang 110016 China Key Laboratory for New Drugs Research of Traditional Chinese Medicine in Shenzhen Research Institute of Tsinghua University in Shenzhen Shenzhen 518057 China College of Traditional Chinese Materia Medica.Shenyang Pharmaceutical University Shenyang 110016 China Key Laboratory for New Drugs Research of Traditional Chinese Medicine in Shenzhen Research Institute of Tsinghua University in Shenzhen Shenzhen 518057 China

Objective To search for chemical constituents with anti-oxidative activity from seeds of Jatropha curcas. Methods DPPH radical scavenging assay was used to screen fractions or constituents with anti-oxidative activities. Active fractions were separated by varied chromatography and then identified on the basis of physiochemical properties and spectroscopic methods. Results The n-butanol layer of ethanol extract from the seeds of J. curcas showed stronger activity than other fractions and was studied further. A new compound was isolated from this active layer, and its structure was identified as jatrophasin A (3,4,4′,5′-tetrahydroxyl-3′-methoxyl-bisepoxylignan, 1). It showed stronger anti-oxidative activity compared with resveratrol. Conclusion Compound 1 is a new compound which has never been reported with strong anti-oxidative activity.

关键词： anti-oxidative activity DPPH jatrophasin A resveratrol seeds of Jatropha curcas

Chemical Constituents in Extracts from Leaves of Lantana trifolia and Their In Vitro anti-oxidative activity

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Chinese Herbal Medicines 2014年第3期6卷 242-246页

作者： Palmer Sivoko Imbenzi Yong-zhi He Zhi-xue Yan Eric Kibagendi Osoro Peter K Cheplogoi College of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine Chemistry Department Egerton University P.O. Box 536 EgertonKenya

Objective To isolate, purify, and analyze the anti-oxidants trom the leaves of Lantana trifolia. Methods The anti-oxidative activities of the crude extracts from liquid-liquid extraction of L. trifolia leaves were assayed by 1,1-diphenyl-2-picrylhydrazyl （DPPH） method to assess their radical scavenging and reducing abilities. The total flavonoids and phenol contents in the ethyl acetate fraction were determined by colorimetric and Folin-Ciocalteu methods, respectively. Chemical constituents were isolated from the ethyl acetate fraction and repeatedly purified using silica gel, Sephadex LH-20 column chromatography, and HPLC, respectively. The chemical structures isolated were identified by spectral analysis and chemical evidence. Results Ethyl acetate partition from liquid-liquid extraction exhibited the highest anti-oxidative activity with an IC50 value of 4.94 μg/mL, close to that of the standard （vitamin C, VC, 4.23 μg/mL）. The extract was proved to contain total flavonoids and phenol contents with values of （39.0±1.6） and （29.27 ± 1.46） mg/g, respectively. Six compounds were isolated and identified as kaempferol-3,7-dimethyl ether （1）, verbascoside （2）, apigenin （3）, umuhengerin （4）, ladanetin （5）, and scutellarein-7-O-β-D-apiofuranoside （6）. Conclusion The ethyl acetate extract from the leaves of L. trifolia possesses the potent anti-oxidative and free radical scavenging activities which are directly proportional to the concentration of phenolic contents. The anti-oxidative activity of the extract from the leaves of L. trifolia is due to its proton donating ability that converts free radicals to more stable products and terminates chain reactions. Compound 1 is isolated from the plants of Lantana Linn. for the first time. The mechanisms may be related to the therapeutic benefits of the certain traditional claims of wild L. trifolia.

关键词： anti-oxidative activity diphenyl picryl hydrazine Lantana trifolia

Chemical constituents from the submerged plant Potamogeton crispus and their effects on NAD(P)H:quinone oxidoreductase 1

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Chinese Chemical Letters 2012年第10期23卷 1157-1160页

作者： Miao Ye Jun Zhi Ma Juan Xiong Shu Ting Liu Dong Wang Chong Gang Yuan Ji Yan Ma Jin Feng Hu Department of Natural Products for Chemical Genetic Research Key Laboratory of Brain Functional GenomicsEast China Normal UniversityShanghai 200062China Department of Natural Products Chemistry School of PharmacyFudan UniversityShanghai 201203China School of Life Science East China Normal UniversityShanghai 200062China

A new isopimarane-type diterpene （liwariverol, 1） and eight known compounds were isolated and characterized from the EtOAc extract of the whole plant of Potamogeton crispus. The structure of 1 was elucidated to be 17-hydroxy-8c^H-isopimara-9（11）,15- diene by means of spectroscopic methods. Among the isolates, crenulatoside A （2）, an acyclic sesquiterpene glycoside, was found to have anti-oxidative activity with enhancement of the expression of the NAD（P）H：quinone oxidoreductase 1 （NQO1） in human neuroblastoma SH-SY5Y cells at 100 μmol/L after a 24-h incubation.

关键词： Potamogeton crispus Potamogetonaceae Isopimarane-type diterpene Crenulatoside A NQO1 anti-oxidative activity

Extraction of Triterpenoids with antioxidant and anti-tumor activity from Agrocybe aegerita Mycelium and Spent Culture Medium

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食用菌学报 2007年第2期 44-47页

作者： YUAN Guangfeng1, XU Ruiya2, ZHANG Shubin1, WANG Li’an11Life Science College of Hebei Normal University, Shijiazhuang, Hebei 050016, China 2 Xuanhua Campus of Zhangjiakou Institute of Education, Xuangha, Hebei 075100, China

Different organic solvents (petroleum ether, ethyl acetate and ethanol) were used to extract A. aegerita mycelium and spent culture medium following growth of the fungus in submerged culture. All the extracts exhibite... 详细信息

关键词： Agrocybe aegerita anti-oxidative activity anti-tumor activity Triterpenoid Human gastric cancer cell (BGC-823)

Comparative Study of anti-oxidative Effects of Tibetan Folk Medicine Erigeron multiradiatus during Plant Growth

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Chinese Herbal Medicines 2011年第3期3卷 207-213页

作者： ZHANG Zhi-feng1,LIU Yuan1,LUO Pei 2,ZHANG Hao3 1.Ethnic Pharmaceutical Institute of Southwest University for Nationalities,Chengdu 610041,China 2.Teaching Division,School of Chinese Medicine,Hong Kong Baptist University,Kowloon Tong,Kowloon,Hong Kong,China 3.West China School of Pharmacy,Sichuan University,Chengdu 610041,China Ethnic Pharmaceutical Institute of Southwest University for Nationalities Chengdu 610041China Teaching Division School of Chinese MedicineHong Kong Baptist UniversityKowloon TongKowloonHong KongChina West China School of Pharmacy Sichuan UniversityChengdu 610041China

Objective To explore the effects of a potential anti-oxidative plant,Erigeron multiradiatus(Asteraceae) ,plant materials from naturally distributed high-altitude populations at different stages of life cycle were *** Fifteen extracts obtained from the Ganzi region(Sichuan,China) were studied to assess their radical-scavenging ability on 1,1-diphenyl-2-picrylhydrazyl radicals and reducing power ***,considering that anti-oxidants and free radical scavengers can also exert protective effect on endothelial cells from oxidative injury,these extracts were also evaluated for their anti-oxidative activity against cellular injury in the cultured human endothelial cell line(ECV304) induced by hydrogen peroxide(H2O2) .Results All the extracts had radical-scavenging and/or reducing power ability,and the most active extract was found during flowering whereas the lowest appeared during vegetative growth *** accumulation of anti-oxidative compounds was found to be affected by the altitude of growth *** flavonoid content assay was also performed to support this ***,these extracts also exhibited different effects on attenuating H2O2-induced cytotoxicity and inhibiting lipid peroxidation and LDH leakage from endothelial *** *** may be an important natural anti-oxidant and this property may contribute to verifying the utilization of this plant in Tibet folk medicine.

关键词： anti-oxidative activity developmental stage endothelial cells Erigeron multiradiatus hydrogen peroxide

A Correlation of anti-oxidative property and Vaso-relaxation Effect of Major Active Constituents of Traditional Chinese Medicine

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A Correlation of Anti-oxidative property and Vaso-relaxation...