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anti-microbial principles of selected remedial plants from Southern India

Asian Pacific Journal of Tropical Biomedicine 2011年第4期1卷 298-305页

作者： Tirupathi Rao G Suresh Babu K J Ujwal Kumar Sujana P A Veerabhadr Raoa Sreedhar AS Centre for Cellular and Molecular Biology Hyderabad 500 007India Division of Organic Chemistry-I Natural Products LaboratoryIndian Institute of Chemical TechnologyHyderabad-500 607India

Objective:To examine the anti-bacterial activity of leaf extracts of Morus alba L.(Moraceae)and Piper betel L.(Piperaceae),and seed extracts of Bombax ceiba L.(Borabacaceae).Methods:We have partially purified plant extracts by solvent extraction method,and evaluated the effect of individual fractions on bacterial growth using Escherichia coli(***),Pseudomonas aeruginosa(***) and Staphylococcus aureus(***) bacterial ***:Compared with Morus and Bombax fractions,Piper fractions showed significant growth inhibition on all the three types of bacteria *** EtOAc-hexane fractions of Piper leaves exhibited significant antibacterial activity with minimum inhibitory concentrations(MIC) of 50 μg/mL culture against both gram-positive and gram-negative *** EtOAc-fractions Ⅰ,Ⅱ,and Ⅳ inhibited bacterial colony formation on soft agar in addition to growth inhibition.A combination treatment of piper fractions with ampicillin resulted in significant growth inhibition in *** and ***,and combination with anticancer drug geldanamycin(2 μg/mL) showed selective growth inhibition against *** and *** major compounds,i.e.,eugenol,3-hexene-ol and stigmasterol,were primarily identified from Piper betel leaf *** the individual compounds,eugenol treatment showed improved growth inhibition compared with stigmasterol and ***:We are reporting potential anti-bacterial compounds from Piper betel against both gram-positive and gram-negative bacteria either alone or in combination with drug treatment.

关键词： Piper betel anti-microbial activity Escherichia coli Pseudomonas aeruginosa Staphylococcus aureus Morus alba Bombax ceiba Minimum inhibitory concentration Growth inhibition

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Preparation and Activity of a Nanometer anti-microbial Polyurethane

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Journal of Wuhan University of Technology(Materials Science) 2009年第4期24卷 540-545页

作者：关燕清彭长连 School of Life Science South China Normal University MOE Key laboratory of Laser Life Science South China Normal University

A novel way for photo-immobilization with interferon- α（IFN- α） on the surface of polyurethane （PU） material, which makes PU condom more effective function in the future, was investigated. A kind of photoactive arylazide-4-azidobenzoic acid was modified to IFN- α with the confirmation of IR and Raman spectrum. Micro morphology of the photo-immobilized cell factors was observed by FESEM as well as CSLM at the level of nanometer. Finally, the product with elementary test of anti-microbial was also evaluated.

关键词： polyurethane (PU) interferon-α (IFN- α) photo-immobilization anti-microbial

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Synthesis,Crystal Structure and Evaluations of Its Cytotoxicity,anti-microbial and anti-hydroxyl Radical Activities of a New Co-crystal Compound(C6H6Cl2N2O2S)·(Phen)·H2O

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Chinese Journal of Structural Chemistry 2018年第7期37卷 1078-1086页

作者：黄岚珍王雅楠蔡卓秦秀英 College of Pharmacy Guilin Medical University Center for Science Research Guilin Medical University School of Chemistry and Chemical Engineering Guangxi University

Co-crystal is a very potential kind of drug solid forms, and has a far-reaching influence on designing and preparing drugs. A new 1：1：1 co-crystal compound consisting of 4-amino-3,5-dichloro-benzenesulfonamide, 1,10-phenanthroline and water was synthesized, and its crystal structure was characterized by X-ray diffraction method. The compositions of the co-crystal are self-assembled into a three-dimensional network structure via intermolecular interactions including hydrogen bonds, π-π stacking, Cl？？？Cl interactions and van der Waals＇ forces. According to the evaluations of cytotoxicity assays, anti-microbial and anti-hydroxyl radicals, this co-crystal is a potential drug.

关键词： 4-amino-3,5-dichloro-benzenesulfonamide co-crystal cytotoxicity anti-microbial anti-hydroxyl radical

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Comparison study of anti-microbial activity between crude extract of Kappaphycus alvarezii and Andrographis paniculata

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Asian Pacific Journal of Tropical Biomedicine 2017年第8期7卷 729-731页

作者： Xin Qi Chuah Wenlynn Mun Swee Sen Teo Department of Biotechnology UCSI UniversityKuala LumpurMalaysia

To evaluate the antimicrobial properties of Kappaphycus alvarezii (K. alvarezii) and Andrographis paniculata (A. paniculata) and to compare the microbial inhibition activities between these two crude *** K. alvarezii and A. paniculata were extracted with methanol before the commencement of antimicrobial properties studies. There were a total of eight species of bacteria, including Gram-positive bacteria Bacillus cereus, Bacillus subtilis, Staphylococcus aureus and Staphylococcus epidermidis and Gram-negative bacteria, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Salmonella enterica. The antimicrobial activity was tested by disk diffusion *** extract of K. alvarezii was found not effective against both Gram-positive and Gram-negative bacteria. In contrast, A. paniculata showed higher inhibition towards the growth of Gram-positive bacteria compared to Gram-negative bacteria. Results revealed that Bacillus subtilis was susceptible at lower concentration of A. paniculata crude extract however Staphylococcus epidermidis was the most susceptible towards A. paniculata at higher concentration. Although the inhibition zones produced by the crude extract were smaller than that of the positive control, streptomycin disc, A. paniculata crude extract still can be considered as potential antimicrobial agents either because it is a natural product or the active compound which is yet identified from its crude *** extract of K. alvarezii has zero inhibition in bacteria growth whereas A. paniculata exerted higher inhibition towards Gram-positive bacteria. The bioactive compounds contained by A. paniculata can be evaluated in order to yield a better vision towards the mode of action.

关键词： Kappaphycus alvarezii Andrographis paniculata anti-microbial Gram-positive Gram-negative

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Formosins A-F: Diterpenoids with anti-microbial Activities from Excoecaria formosana

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NATURAL PRODUCTS AND BIOPROSPECTING 2016年第1期6卷 57-61页

作者： Lin, Bing-Dong Zhou, Bin Dong, Lei Wu, Yan Yue, Jian-Min Chinese Acad Sci Shanghai Inst Mat Med State Key Lab Drug Res 555 Zuchongzhi Rd Shanghai 201203 Peoples R China

Three new halimane-type diterpenoids formosins A-C (1-3), and three clerodane-type diterpenoids formosins D-F (4-6), were isolated from the twigs of Excoecaria formosana. Their structures were assigned on the basis of spectroscopic data analysis. Compounds 1 and 4 showed moderate anti-microbial activities against Bacillus subtilis (MIC = 50 and 50 mu g/mL, respectively). Compound 6 exhibited moderate anti-microbial activities against two strains of Helicobacter pylori (Hp-SS1 and ATCC 43504) with MIC values of 50 and 50 mu g/mL, respectively.

关键词： Excoecaria formosana Halimane-type Clerodane-type Diterpenoid anti-microbial AGALLOCHA MANGROVE

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Phytochemicals Screening, Phenolic Estimation and Evaluation for anti-Oxidant, anti-Inflammatory and anti-microbial Activities of Sequentially Soxhlet Extracted Coconut Testa

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Food and Nutrition Sciences 2019年第8期10卷 900-922页

作者： Sashi Bhusan Ojha Shaktirekha Roy Soumya Das Gunanidhi Dhangadamajhi Department of Biotechnology North Orissa University Baripada Odisha India

Background: In many coconut industries, the outer layer of thin brown skin of coconut kernel known as testa is peeled out as a byproduct. Despite the testa is rich in fat and plenty of polyphenolic compounds, it has been underutilized either as animal feed, serving as raw materials for bio-diesel production or discarded directly. anticipating coconut testa (CT) as a natural source of multiple phyto-chemicals, its exploitation for the pharmacological activity or utilization as value added product is required which may reduce the disposal costs as well. Methods: Secondary metabolites from CT were extracted sequentially with different organic solvents based on polarity in the soxhlet apparatus followed by extraction with sterilized water. The crude dried extracts thus prepared were evaluated for qualitative screening of phytochemicals and quantitative estimation of total phenols, flavonoids and tannin content. Moreover, the antioxidant, anti-inflammatory and anti-microbial activities were also investigated. Results: Phytochemicals screening revealed the presence of polyphenolic compounds in methanolic fraction including phenols (822.60 ± 16.36 mg/g), flavonoids (103.30 ± 9.78 mg/g) and tannin (663.50 ± 19.26 mg/g), whereas non-phenolic compounds were present in other fractions. While methanolic fraction showed invariably the highest anti-oxidant activity in multiple assay methods, non-phenolic compounds in aqueous and chloroform fractions exhibited high anti-inflammatory activity. antimicrobial activity was observed by both phenolic and non-phenolic compounds. Conclusion: The findings of the study reveal that CT is a rich source of various polyphenolic and non-phenolic natural antioxidants, anti-inflammatory and antimicrobial compounds. These findings are promising and form the basis to identify the number of active components and their characterization.

关键词： Coconut Testa Phytochemicals anti-Oxidant anti-Inflammatory anti-microbial Soxhlet Extraction

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antimicrobial Activity of Ulva reticulata and Its Endophytes

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Journal of Ocean University of China 2016年第2期15卷 363-369页

作者： Dhanya K.I. Swati V.I. Vanka Kanth Swaroop Osborne W.J. School of Biosciences and Technology lilT UniversityVellore-632014lndia

Seaweeds are known to exhibit various antimicrobial properties, since it harbours an enormous range of indigenous bioactive compounds. The emergence of drug resistant strains has directed to the identification of prospective metabolites from seaweed and its endophytes, thereby exploiting the properties in resisting bacterial diseases. The current study was aimed to assess the antimicrobial activity of extracts obtained from Ulva reticulate, for which metabolites of Ulva reticulata and its endophytes were extracted and assessed against human pathogens like Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, and Bacillus subtilis. It was observed that the hexane extract of isolate VITDSJ2 was effective against all the tested pathogens but a significant inhibition was observed for Staphylococcus aureus and Escherichia coli. Further, Gas chromatography coupled with Mass spectroscopy （GC-MS） revealed the existence of phenol, 3, 5-bis （1, 1-dimethylethyl） in the crude hexane extract which is well-known to possess antibacterial activity. The effective isolate VITDSJ2 was identified to be the closest neighbour of Pseudomonas smtzeri by phenotypic and genotypic methods. The crude extracts of the seaweed Ulva reticulata was also screened for antibacterial activity and the hexane extract was effective in showing inhibition against all the tested pathogens. The compound in the crude extract of Ulva reticulata was identified as hentriacontane using GC-MS. The extracts obtained from dichloromethane did not show significant activity in comparison with the hexane extracts. Hence the metabolites of Ulva reticulata and the bacterial secondary metabolites of the endophytes could be used in the treatment of bacterial infections.

关键词： endophytic bacteria anti-microbial macroalgae bioactive compounds GC-MS

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Utilization of Chinese Herbal Feed Additives in Animal Production

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Agricultural Sciences in China 2011年第8期10卷 1262-1272页

作者： LIU Hua-wei TONG Jian-ming ZHOU Dao-wei Northeast Institute of Geography and Agroecology Chinese Academy of SciencesJilin 130012P.R.China State Key Laboratory of Animal Nutrition Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100193P.R.China

The experimental knowledge on efficacy,possible modes of action and aspects of application of Chinese herbs as feed additives for animal production are reviewed in this *** herbs commonly contain protein,carbohydrate,fat,vitamins,andmineral which are necessary nutrients to the growth of ***,organic acid,alkaloids,and essential oils involved in Chinese herbs can improve the immune function of ***,numerous studies have demonstrated anti-oxidative and anti-microbial efficacy and the assumption that Chinese herbs may improve the flavor of meat,which has been confirmed by some observations,but the mode of this action is still ***,several observations support the hypothesis that herbal feed additives may favorably affect gut functions （e.g.,enzyme activity,microbial eubiosis） in *** effects may explain a considerable number of practical studies with livestock reporting improved production performance after providing herbal feed *** summary,available evidence indicates that herbal feed additives may have the potential to add to the set of non-antibiotic growth promoters for use in livestock,such as organic acids and ***,a systematic approach toward the efficacy,mode of action and safety of herbal compounds used as feed additives for animal production seems to be required in the future.

关键词： anti-microbial anti-oxidative Chinese herbs animal production

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NIR‑II‑Triggered Composite Nanofibers to Simultaneously Achieve Intracranial Hemostasis,Killing Superbug and Residual Cancer Cells in Brain Tumor Resection Surgery

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Advanced Fiber Materials 2023年第1期5卷 209-222页

作者： Jun Yang Lei Xu Yining Ding Chang Liu Bingchang Wang Yanchao Yu Chao Hui Seeram Ramakrishna Jun Zhang Yunze Long Collaborative Innovation Center for Nanomaterials&Devices College of PhysicsQingdao UniversityQingdao 266071People’s Republic of China Center for Nanofibers&Nanotechnology Department of Mechanical EngineeringNational University of SingaporeSingapore 117574Singapore

Malignant glioblastoma(GBM)is prone to relapse due to the inevitable tumor cells residue by *** the tumor resection surgery in brain,addressing bleeding and superbug infections is also full of ***,no method or material in clinical craniotomy can simultaneously solve these three ***,Chitosan composite nanofibers embed-ded with CuSe nanoparticles were prepared by green electrospinning method,in which the CuSe nanoparticles have strong absorption in the second near-infrared(NIR-II)*** after removing the tumor in craniotomy,nanofibers were electrospun and deposited directly onto the resection site with high precision(>90%)to achieve rapid hemostasis(99%)and effectively induces cell apoptosis of residual tumor thereby to inhibit tumor *** using the same material,a tril-ogy of intracranial hemostasis,killing superbug and residual cancer cells is simultaneously *** short operation time reduces the risk of *** electrospinning strategy could combine with craniotomy and minimally invasive surgery,which may provide novel perspectives in clinical operation besides craniotomy.

关键词： Electrospinning anti-tumor anti-microbial Hemostasis

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Bioactive metabolites from macrofungi: ethnopharmacology, biological activities and chemistry

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Fungal Diversity 2013年第5期62卷 1-40页

作者： Dilani D.De Silva Sylvie Rapior Enge Sudarman Marc Stadler Jianchu Xu S.Aisyah Alias Kevin D.Hyde Key Laboratory for Plant Biodiversity and Biogeography of East Asia(KLPB) Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina World Agroforestry Centre East Asia NodeBeijingChina Institute of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Department of Botany Faculty of ScienceUniversity of PeradeniyaPeradeniya 20500Sri Lanka Laboratory of Botany Phytochemistry and Mycology Faculty of PharmacyUniversity Montpellier 1UMR 5175 CEFEBP 1449115avenue Charles Flahault34093 Montpellier Cedex 5France Department of microbial Drugs Helmhotz Centre for Infection ResearchBraunschweigGermany Institute of Ocean and Earth Sciences University of Malaya50603 Kuala LumpurMalaysia

Exploration of natural sources for novel bioactive compounds has been an emerging field of medicine over the past decades,providing drugs or lead compounds of considerable therapeutic *** research has provided exciting evidence on the isolation of microbe-derived metabolites having prospective biological *** have been valued as traditional sources of natural bioactive compounds for many centuries and have been targeted as promising therapeutic *** novel biologically active compounds have been reported as a result of research on medicinal *** this review,we compile the information on bioactive structure-elucidated metabolites from macrofungi discovered over the last decade and highlight their unique chemical diversity and potential benefits to novel drug *** main emphasis is on their anti-Alzheimer,antidiabetic,anti-malarial,anti-microbial,anti-oxidant,antitumor,anti-viral and hypocholesterolemic activities which are important medicinal targets in terms of drug discovery ***,the reader’s attention is brought to focus on mushroom products and food supplements available in the market with claimed biological activities and potential human health benefits.

关键词： Medicinal mushrooms anti-oxidant anti-tumor anti-HIV anti-microbial anti-viral Hypocholesterolemic anti-diabetic anti-Alzheimer anti-malarial Food supplements

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