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Novel anti-diabetic agents in non-alcoholic fatty liver disease: a mini-review

Hepatobiliary & Pancreatic Diseases International 2013年第6期12卷 584-588页

作者： Manhal Olaywi Taruna Bhatia Sury Anand Shashideep Singhal Division of Gastroenterology and Hepatology The Brooklyn Hospital Center/New York Presbyterian Healthcare System Division of Digestive and Liver Diseases Columbia University Medical Center

BACKGROUND:Non-alcoholic fatty liver disease(NAFLD)encompasses a spectrum that ranges from simple steatosis to non-alcoholic steatohepatitis(NASH)and to *** recommended treatment for this disease includes measures that target obesity and insulin *** present review summarizes the role of newer anti-diabetic agents in treatment of *** SOURCES:PubMed,MEDLINE and Ovid databases were searched to identify human studies between January 1990and January 2013 using specified key *** studies that enrolled patients with a diagnosis of NAFLD or NASH and involved use of newer classes of anti-diabetic agents for a duration of at least 3 months were ***:Out of the screened articles,four met eligibility criteria and were included in our *** classes of newer anti-diabetic medications described were dipeptidyl peptidase IV inhibitors and glucagon-like peptide-1 ***:Liraglutide and Exenatide showed improvement in transaminases as well as histology in patients with *** showed improvement in transaminases but limited studies are there to access its effect on *** studies are needed to support use of newer anti-diabetic medications in patients with NAFLD.

关键词： non-alcoholic fatty liver disease non-alcoholic steatohepatitis anti-diabetic agents Sitagliptin Exenatide Liraglutide

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Natural and Semisynthetic Protein Tyrosine Phosphatase 1B(PTP1B)Inhibitors as anti-diabetic agents

Natural and Semisynthetic Protein Tyrosine Phosphatase 1B(PT...

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全国第二届海洋与陆地多糖多肽及天然创新药物研发学术会议

作者： Li-Jun Wang Bo Jiang NingWu Shuai-Yu Wang Da-Yong Shi Institute of Oceanology Chinese Academy of Sciences

Diabetes mellitus,which includes both type 1 and type 2 diabetes mellitus(T2DM),is a major disease that threatens human health *** tyrosine phosphatase IB(PTPIB)is a promising molecular-level therapeutic target that is effective in the management of *** products with various skeletons and diverse bioactivities offer opportunities for the development of new drugs and lead compounds with potent inhibitory activity against PTPIB in vitro and in ***,a number of potent PTPIB inhibitors have been obtained from natural sources or prepared by synthesis/semi-synthesis,and they exhibit potential for the treatment of *** this review,we discuss the development of potent natural and semisynthetic PTPIB inhibitors with ICvalues under 10μM over the past six years(2009-2014),including their structural features,biological features,structure-activity relationships(SARs).We also discuss strategies for identifying potent PTPIB inhibitors from natural products to provide useful information for use by medicinal chemists in developing potent PTPIB inhibitors as T2DM treatments.

关键词： Diabetes mellitus protein tyrosine phosphatase 1B(PTP1B) type 2 diabetes mellitus(T2DM) natural PTP1B inhibitors synthesis structure-activity relationships(SARs) anti-diabetic agents

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Natural and Semisynthetic Protein Tyrosine Phosphatase 1B(PTP1B)Inhibitors as anti-diabetic agents

Natural and Semisynthetic Protein Tyrosine Phosphatase 1B(PT...

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全国第九届海洋生物技术与创新药物学术会议

作者： Li-Jun Wang Bo Jiang Ning Wu Shuai-Yu Wang Da-Yong Shi Institute of Oceanology Chinese Academy of Sciences

Diabetes mellitus,including type 1 and type 2 diabetes mellitus(T2DM)is a kind of major diseases that threaten the human health in the *** tyrosine phosphatase 1B(PTP1B)is a promising molecular level legitimate therapeutic target,which was effectively management of *** products with various skeletons and diverse bioactivities offer more opportunities to develop new drugs and leading compounds with potent inhibitory activity against PTP1B in vitro and in ***,a number of potent PTP1B inhibitors have been obtained from natural sources or prepared by synthesis/semi-synthesis,which exhibited the potential ability in the treatment of *** this review will discuss the developments of the potent natural and semisynthetic PTP1B inhibitors with ICvalues under 10μM during the past five years(2009-2013)with their structural features,biological features,the structure-activity relationships(SARs)and strategies for searching potent PTP1B inhibitors from natural products in order to provide useful information for the medicinal chemist to develop potent PTP1B inhibitor as treating T2DM drugs.

关键词： Diabetes mellitus protein tyrosine phosphatase 1B(PTP1B) type 2 diabetes mellitus(T2DM) natural PTP1B inhibitors synthesis structure-activity relationships(SARs) anti-diabetic agents

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Medicinal mushrooms in prevention and control of diabetes mellitus

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Fungal Diversity 2012年第5期56卷 1-29页

作者： Dilani D.De Silva Sylvie Rapior Kevin D.Hyde Ali H.Bahkali Institute of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand Faculty of Pharmacy University Montpellier 1UMR 5175 CEFEBP 1449115avenue Charles Flahault34093 Montpellier Cedex 5France School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Botany and Microbiology Department College of ScienceKing Saud UniversityRiyadh 11442Saudi Arabia

Diabetes mellitus is a life-threatening chronic metabolic disease caused by lack of insulin and/or insulin dysfunction,characterized by high levels of glucose in the blood(hyperglycemia).Millions worldwide suffer from diabetes and its ***,it has been recognized that type 2 diabetes is an important preventable disease and can be avoided or delayed by lifestyle ***,there are many chemical and biochemical hypoglycemic agents(synthetic drugs),that are used in treating diabetes and are effective in controlling ***,as they may have harmful side-effects and fail to significantly alter the course of diabetic complications,natural anti-diabetic drugs from medicinal plants have attracted a great deal of *** mushrooms have been valued as a traditional source of natural bioactive compounds over many centuries and have been targeted as potential hypoglycemic and anti-diabetic *** metabolites including polysaccharides,proteins,dietary fibres,and many other biomolecules isolated from medicinal mushrooms and their cultured mycelia have been shown to be successful in diabetes treatment as biological antihyperglycemic *** this review we discuss the biological nature of diabetes and,in particular,explore some promising mushrooms that have experimental anti-diabetic properties,preventing or reducing the development of diabetes *** importance of medicinal mushrooms as agents of medical nutrition therapy and how their metabolites can be used as supportive candidates for prevention and control of diabetes is *** prospects for this field of study and the difficulties and constraints that might affect the development of rational drug products from medicinal mushrooms are discussed.

关键词： Medicinal mushrooms Diabetes mellitus anti-diabetic agents anti-hyperglycemic agents Bioactive metabolites Mushroom supplementation Diabetes prevention

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