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anti-cd tcr antibody-expanded cd T cells:a better choice for the adoptive immunotherapy of lymphoid malignancies

Cellular & Molecular Immunology 2012年第1期9卷 34-44页

作者： Jianhua Zhou Ning Kang Lianxian Cui Denian Ba Wei He Department of Immunology Institute of Basic Medical SciencesChinese Academy of Medical Sciences and School of Basic MedicinePeking Union Medical CollegeNational Key Laboratory of Medical Molecular BiologyBeijingChina

Cell-based immunotherapy for lymphoid malignancies has gained increasing attention as patients develop resistance to conventional *** T cells,which have major histocompatibility complex(MHC)-unrestricted lytic activity,have become a promising candidate population for adoptive cell transfer *** previously established a stable condition for expanding cd T cells by using anti-cd T-cell receptor(tcr)*** this study,we found that adoptive transfer of the expanded cd T cells to Daudi lymphoma-bearing nude mice significantly prolonged the survival time of the mice and improved their living *** further investigated the characteristics of these antibody-expanded cd T cells compared to the more commonly used phosphoantigen-expanded cd T cells and evaluated the feasibility of employing them in the treatment of lymphoid *** but sustained proliferation of human peripheral blood cd T cells was observed upon stimulation with anti-cd tcr *** to phosphoantigen-stimulated cd T cells,the antibody-expanded cells manifested similar functional phenotypes and cytotoxic activity towards lymphoma cell *** is noteworthy that the anti-cd tcr antibody could expand both the Vd1 and Vd2 subsets of cd T *** in vitro-expanded Vd1 T cells displayed comparable tumour cell-killing activity to Vd2 T ***,owing to higher C–C chemokine receptor 4(CCR4)and CCR8 expression,the Vd1 T cells were more prone to infiltrate CCL17-or CCL22-expressing lymphomas than the Vd2 T *** the peripheral blood cd T cells from lymphoma patients further confirmed that the anti-cd tcr antibody-expanded cd T cells could be a more efficacious choice for the treatment of lymphoid malignancies than phosphoantigen-expanded cd T cells.

关键词： adoptive cell therapy anti-cd tcr antibody cd T cells lymphoid malignancies Vd1 subset

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