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AFAP1-AS1: a rising star among oncogenic long non-coding RNAs

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Science China(Life Sciences) 2021年第10期64卷 1602-1611页

作者： Fang Xiong Kunjie Zhu Su Deng Hongbin Huang Liting Yang Zhaojian Gong Lei Shi Yi He Yanyan Tang Qianjin Liao Jianjun Yu Xiaoling Li Yong Li Guiyuan Li Zhaoyang Zeng Wei Xiong Shanshan Zhang Can Guo Science and Technology on Information System Engineering Laboratory National University of Defense TechnologyChangsha 410000China Department of Periodontology Center of StomatologyXiangya HospitalCentral South UniversityChangsha 410078China NHC Key Laboratory of Carcinogenesis and Key Laboratory of Carcinogenesis and cancer Invasion of Ministry of Education of China Cancer Research InstituteCentral South UniversityChangsha 410078China Hunan Key Laboratory of cancer Metabolism Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410013China Department of Oral and Maxillofacial Surgery The Second Xiangya HospitalCentral South UniversityChangsha 410011China Department of Medicine Dan L Duncan Comprehensive Cancer CenterBaylor College of MedicineHoustonTexasUSA

Long non-coding RNAs(lncRNAs)have become a hotspot in biomedical *** interest reflects their extensive involvement in the regulation of the expression of other genes,and their influence on the occurrence and development of a variety of human *** filament associated protein 1-antisense RNA 1(AFAP1-AS1)is a recently discovered oncogenic *** is highly expressed in a variety of solid tumors,and regulates the expression of downstream genes and signaling pathways through adsorption and competing microRNAs,or by the direct binding to other ***,AFAP1-AS1 promotes proliferation,chemotherapy resistance,and resistance to apoptosis,maintains stemness,and enhances invasion and migration of tumor *** paper summarizes the research concerning AFAP1-AS1 in malignant tumors,including the clinical application prospects of AFAP1-AS1 as a potential molecular marker and therapeutic target of malignant *** also discuss the limitations in the knowledge of AFAP1-AS1 and directions of further ***1-AS1 is expected to provide an example for studies of other lncRNA molecules.

关键词： AFAP1-AS1 metastasis proliferation anti-cancer drug PD-1 immunotherapy

Non-Flat Bisbenzylisoquinoline Alkaloid Fangchinoline As a Class of Potent G-Quadruplex Stabilizer with anti-cancer Activity

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Chinese Journal of Chemistry 2015年第9期33卷 1041-1048页

作者： Qian Li Junfeng Xiang Yalin Tang Beijing National Laboratory for Molecular Sciences (BNLMS) Center for Molecular SciencesState Key Laboratory for Structural Chemistry of Unstable and Stable Species Institute of Chemistry Chinese Aeademy of Sciences Beijing 100190 China

Compounds selectively binding and stabilizing G-quadruplex structures could inhibit the telomerase or down- regulate the oncogenes and may act as anti-cancer drugs. An alkaloid with non-flat structure, fangchinoline, showed to strongly stabilize the intermolecular and intramolecular parallel stranded G-quadruplex structure, increasing melting temperature by 20 and 23℃, respectively. The binding mode was investigated by using NMR and molec- ular modelling methods. Four human cell lines （HL-60, BGC-823, Be1-7402 and KB） were taken to test the an- ti-proliferation effects of fangchinoline and the IC50 values were ranged from 16 to 32 μmol/L. These results showed that the fangchinoline or related moiety derivatives may represent a class of telomere-targeted agents as po- tential anti-cancer drugs.

关键词： G-quadruplex alkaloid non-flat anti-cancer drug

Radiation Parameters of Some Potential Bioactive Compounds

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光谱学与光谱分析 2015年第6期35卷 1501-1505页

作者： Zeynep Gedik Mehtap Tugrak Aysenur Dastan Halise Inci Gul Demet Yilmaz Department of Physics Faculty of SciencesAtatürk University Department of Pharmaceutical Chemistry Faculty of PharmacyAtatürk University

In this study,we aimed to determine the radiation parameters of some potential bioactive compounds.1-Aryl-3-dibenzylamino-propane-1-on hydrochloride type Mannich bases were synthesized via classical conventional heating *** part was changed as phenyl(C6H5),4-methylphenyl(4-CH3C6H4),4-fluorophenyl(4-FC6H4),4-nitrophenyl(4-NO2C6H4),4-chlorophenyl(4-ClC6H4),4-bromophenyl(4-BrC6H4),and 2-thienyl(C4H3S-2-yl).Mass attenuation coefficient(μm),effective atomic number(Zeff)and effective electron density(Nel)of compounds were determined experimentally and theoretically for at 8.040,8.910,13.40,14.96,17.48,19.61,22.16,24.94,32.19,36.38,44.48,50.38and 59.54keV photon energies by using an HPGe detector with a resolution of 182eV at *** parameters of these compounds which can be anti-cancer drug candidate were given in the *** results show that phenyl ring behave like thiophene ring in terms of radiation *** is thought that the results of study may drive allow the development of drug candidate new compounds in medical oncology.

关键词： Mass attenuation coefficient Effective atomic number Effective electron density Mannich bases anti-cancer drug

Recombinant expression of different mutant K-ras gene in pancreatic cancer Bxpc-3 cells and its effects on chemotherapy sensitivity

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Science China(Life Sciences) 2014年第11期57卷 1011-1017页

作者： SHAO TengFei ZHENG Yuanting ZHAO Bei LI Tao CHENG KeGuang CAI WeiMin Department of Clinical Pharmacy School of Pharmacy Fudan University Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources Ministry of Education of China School of Chemistry& Chemical Engineering Guangxi Normal University

K-ras is a member of ras gene family which is involved in cell survival,proliferation and *** a mutation occurs in ras gene,the activation of Ras proteins may be prolonged to induce ***,the relationship between K-ras mutation and clinical outcomes in pancreatic cancer patients treated with chemotherapy agents is still under *** this study,we constructed five pAcGFP1-C3 plasmids for different types of K-ras gene(WT,G12V,G12R,G12D,and G13D)and stably transfected human pancreatic cancer Bxpc-3 cells with these *** wild type and mutant clones showed a comparable growth and expression of K-Ras-GFP fusion *** expression of some K-ras mutations resulted in a reduced sensitivity to gefitinib,5-FU,docetaxel and gemcitabine,while showed no effects on erlotinib or ***,compared with the wild type clone,K-Ras downstream signals(phospho-Akt and/or phospho-Erk)were increased in K-ras mutant ***,different types of K-ras mutation had non-identical K-Ras downstream signal activities and drug *** results are the first to reveal the relationship between different K-ras mutation and drug sensitivities of these anti-cancer drugs in pancreatic cancer cells in vitro.

关键词： cancer chemotherapeutic anti-cancer drug K-ras mutation plasmids pancreas

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Virtual screening for triple-negative breast cancer cell inhibitors based on telomere G-quadruplex structure

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Journal of Chinese Pharmaceutical Sciences 2020年第6期29卷 383-389页

作者： Hua Deng Chao Gao Dengguo Wei Sisi Liu Department of Chemistry College of ScienceHuazhong Agricultural UniversityWuhan 430070China

Triple-negative breast cancer is an aggressive subtype that frequently develops resistance to chemotherapy. It is expected to develop new anti-tumor drugs through targeting the structure of G-quadruplexes of the genes associated with this tumor. In this work, by targeting the 21-mer telomere G-quadruplex structure, compounds VB07 and VC02 were identified to stabilize the telomere G-quadruplex through structure-based high-throughput virtual screening. Cell cytotoxicity assay showed that VB07 and VC02 exhibited inhibitory effect on triple-negative breast cancer cells at the concentration of 5 μM. This study showed that structure-based high-throughput virtual screening was able to successfully identify the proper compounds targeting the telomere G-quadruplex, which exhibited inhibitory effects against the triple-negative breast cancer cells.

关键词： Triple-negative breast cancer Telomere G-quadruplex Structure-based virtual screening anti-cancer drug

The anti-tumoral and immunomodulatory effects of rh CNB are mediated by Toll-like receptor 4

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The anti-tumoral and immunomodulatory effects of rh CNB are ...

STUDY OF THE MOLECULAR MECHANISM OF cancerICIDAL EFFECT OF NORCANTHARIDINUM

中国生物化学与分子生物学会2016年全国学术会议

作者： Jinju Yang Hongwei Zhang Rui Yang Yadan Gao Nannan Qin Benqiong Xiang Qun Wei Department of Biochemistry and Molecular Biology Beijing Normal University Gene Engineering and Biotechnology Beijing Key Laboratory Institute of Process Engineering Chinese Academy of Science

Previous results have shown rh CNB promoted cytokines production and stimulated the expression of the surface molecules as an immune-stimulatory protein,and it could be a potential anti-cancer *** results revealed exogenous rh CNB was internalized into the tumour cells by TLR4 receptor *** it remains unknown whether the anti-tumoral and

关键词： rhCNB Toll-like receptor 4 anti-tumor immunity anti-cancer drug

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南通大学学报(医学版) 1991年第4期 354-354页

作者： Liu Fei, Department of Biochemistry, Nantong Medical College

Norcantharidinura is studied to show the inhibiting effect of the activity of calmodulin-stimulated cyclic nucleotide phosphodiesterase. IC=2.8 mmol/L. The drug can also inhibit the basal activity of phosphodiesterase when its concentration is over 1.0mmol/L. These results are supposed to be the molecular pharmacological basis of norcantharidinum on cancer.

关键词： norcantharidinum calmodulin cyclic nucleotide phosphodiesterase anti-cancer drug