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A strategy for mechanically integrating robust hydrogeltissue hybrid to promote the anti-calcification and endothelialization of bioprosthetic heart valve

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Regenerative Biomaterials 2024年第2期3卷 123-136页

作者： Haoshuang Wu Nuoya Chen Tiantian Zheng Li Li Mengyue Hu Yumei Qin Gaoyang Guo Li Yang Yunbing Wang National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610065China Institute of Clinical Pathology West China Hospital of Sichuan UniversityChengdu 610041China College of Polymer Science and Engineering Sichuan UniversityChengdu 610065China

Bioprosthetic heart valve(BHV)replacement has been the predo-minant treatment for severe heart valve diseases over *** clinically available BHVs are crosslinked by glutaraldehyde(GLUT),while the high toxicity of residual GLUT could initiate calcification,severe thrombosis,and delayed ***,we construed a mechanically integrating robust hydrogel-tissue hybrid to improve the performance of *** particular,recombinant humanized coilagen type Ⅲ(rhCOLⅢ),which was precisely customized with anti-coagulant and pro-endothelialization bioactivity,was first incorporated into the polyvinyl alcohol(PVA)-based hydrogel via hydrogen bond ***,tannic acid was introduced to enhance the mechanicalperfo of PVA-based hvdrogel and interfacial bonding between the hydrogel layer and bio-derived tissue due to the strong affinity for a wide range of *** vitro and in vivo experimental results confirmed that the GLUT-crosslinked BHVs modified by the robust PVA-based hydrogel embedded rhCOLII and TA possessed long-term anti-coagulant,accelerated endothelialization,mild inflammatory response and anti-calcification ***,our mechanically integrating robust hydrogel-tissue hybrid strategy showed the potential to enhance the service function and prolong the service life of the BHVs after implantation.

关键词： bioprosthetic heart valves recombinant humanized collagen typeⅢ endothelialization anti-calcification anti-coagulation

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Preclinical study of a self-expanding pulmonary valve for the treatment of pulmonary valve disease

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Regenerative Biomaterials 2020年第6期7卷 609-618页

作者： Dajun Kuang Yang Lei Li Yang Yunbing Wang National Engineering Research Center for Biomaterials Sichuan UniversityNo 29 Wangjiang RoadChengdu 610064China Venus Medtech(Hangzhou)Inc. 88 Jiangling RoadHangzhou 311053China

In the past decade,balloon-expandable percutaneous pulmonary valves have been developed and applied in clinical ***,all the existing products of pulmonary artery interventional valves in the market have a straight structure design,and they require a preset support frame and balloon *** shape design of the valve limits the application *** addition,the age of the population with pulmonary artery disease is generally low,and the existing products cannot meet the needs of anti-calcification properties and valve material *** this study,through optimization of the support frame and leaflet design,a self-expanding pulmonary valve product with a double bell-shaped frame was designed to improve the match of the valve and the implantation site.A loading and deployment study showed that the biomaterial of the valve was not damaged after being *** flow and fatigue in vitro tests showed that the fabricated pulmonary valve met the hydrodynamic requirements after 2108 accelerated fatigue *** safety and efficacy of the pulmonary valve product were demonstrated in studies of pulmonary valve implantation in 11 *** and echocardiography showed that the pulmonary valves were implanted in a good position,and they had normal closure and acceptable valvular *** 180 days’implantation results showed that the calcium content was 0.31-1.39 mg/g in the anti-calcification treatment group,which was significantly lower than that in the control valve without anti-calcification treatment(16.69 mg/g).Our new interventional pulmonary valve product was ready for clinical trials and product registration.

关键词： pulmonary valve self-expanding double bell-shaped anti-calcification preclinical

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