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anti-angiogenic drugs in cancer therapeutics:a review of the latest preclinical and clinical studies of anti-angiogenic agents with anticancer potential

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 433-458页

作者： Polyxeni Vafopoulou Malamati Kourti Department of Life Sciences European University CyprusNicosia 2404Cyprus Basic and Translational Cancer Research Centre Department of Life SciencesEuropean University CyprusNicosia 2404Cyprus

Cancer is a group of diseases with significant morbidity and *** cancer cells,where energy requirements are exceptionally high,angiogenesis,which is the sprouting of new blood vessels from pre-existing ones,is an important process for tumour survival and ***,extensive research in recent years focuses on the discovery of new anticancer drugs that target *** methodologies have been developed preclinically,including the inhibition of pro-angiogenic factors and their receptors via micromolecular agents or monoclonal antibodies and the inhibition of other compensatory pathways beyond the traditional angiogenic *** purpose of the literature review is to present new anticancer drugs that target the process of angiogenesis and have been under preclinical or clinical investigation during the last five *** new anticancer drugs targeting angiogenesis are identified in the *** results of the in vitro and in vivo evaluation of these drugs show that,apart from inhibiting angiogenesis,they also affect cancer cell proliferation and tumour *** clinical studies show that these drugs increase the overall or disease-free survival of patients,even those with persistent,chemotherapy-resistant and metastatic types of cancer,although treatment-related side effects are not *** that target the process of angiogenesis are likely to be the future of anticancer therapy,especially in cases where more traditional treatments do not produce the desired results and where combination regimens of anti-angiogenic agents with standard chemotherapeutics increase patient survival.

关键词： Angiogenesis cancer anti-angiogenic drugs anticancer drugs chemotherapy malignant angiogenesis angiogenic inhibitors

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