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Analysis Concentration of <i>toxoplasma gondii</i>on anti-toxoplasma IgG-IgM antibody Levels, and the Outcomes of Pregnancy in Mice Balb/c

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Open Journal of Obstetrics and Gynecology 2017年第3期7卷 281-289页

作者： Tigor Peniel Simanjuntak Mochammad Hatta Robert H. Sirait Marni Br Karo Lenny Irmawaty Sirait Tetty Rina Aritonang Syahrul Rauf Ressy Dwiyanti Department of Obstetrics and Gynecology Faculty of Medicine Christian University of Indonesia Jakarta Indonesia Molecular Biology and Immunology Laboratory Faculty of Medicine Hasanuddin University Makassar Indonesia Department of Anaestesiology Faculty of Medicine Christian University of Indonesia Jakarta Indonesia Midwife Program of Medistra Health Higher School Jakarta Indonesia Department of Obstetrics and Gynecology Faculty of Medicine Hasanuddin University Makassar Indonesia Department of Medical Microbiology Faculty of Medicine Tadulako University Palu Indonesia

Introduction: toxoplasma gondii is an obligate intracellular protozoan parasite that can infect any warm blood vertebrae, and if first trimester pregnant woman infected, it may cause abortion. The objective is to prove the effect of the toxoplasma gondii concentration in anti-toxoplasma IgG-IgM antibody levels, and the outcomes of Balb/c mice pregnancies. Materials and Methods: The study was conducted in Balb/c mice with inclusion criteria, and was conditioned pregnant. The pathogen strains of toxoplasma gondii tachyzoite injected intraperitoneally. The blood samples were taken serially to be tested for anti-toxoplasma IgG-IgM antibody levels. After the mice were injected with tachyzoite, they are assessed every day to observe their body weight, vaginal bleeding, and labor. anti-toxoplasma IgG-IgM antibody levels examined using qualitative mouse IgG-IgM antibody ELISA KIT. Results: anti-toxoplasma IgM antibody levels increased significantly after 24 hours of injection tachyzoites in all dose groups, and remained high through day 21. anti-toxoplasma antibody IgG levels increased significantly after 72 hours post injection and remained elevated until day 21. The incidence of abortion is 100% in mice which injected tachyzoite levels 1 × 103 and 1 × 104, and the incidence of abortion approximately 2 - 4 days post injection. 100% of mice that were injected with tachyzoites 1 × 101 and 1 × 102 have labor at term. Physical anomaly was found in baby mice from mice that were injected with tachyzoite 1 × 102. Conclusion: There is a significant correlation between the concentrations of toxoplasma gondii tachyzoite with anti-toxoplasma IgG-IgM antibody levels, and there is a significant relationship between the concentrations of tachyzoite with abortion.

关键词： toxoplasma gondii Tachyzoite anti-toxoplasma IgG-IgM antibody Levels Pregnancy Abortion Labor

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Recurrent headaches may be caused by cerebral toxoplasmosis

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World Journal of Clinical Pediatrics 2014年第3期3卷 59-68页

作者： Joseph Prandota Anna Gryglas Aleksander Fuglewicz Agata Zesawska-Faleńczyk Barbara Ujma-Czapska Leszek Szenborn Janusz Mierzwa Department of Social Pediatrics Faculty of Health Sciences Wroclaw Medical University 51618 Wroclaw Poland Department of Pediatric Neurology Taddeus Marciniak Specialistic Hospital 50420 Wroclaw Poland Department of Pediatrics and Infectious Diseases Wroclaw Medical University 50345 Wroclaw Poland Department of Neurosurgery Wroclaw Medical University 50420 Wroclaw Poland

AIM: To establish seroprevalence and provide characteristics of toxoplasma gondii(TG) infection in children with recurrent headaches. METHODS: The study was performed in 178 children aged 7-17 years admitted consecutively to the Department of Pediatric Neurology from November 2009 to July 2011. The children were surveyed with a questionnaire with the help and assistance of their parents and blood samples taken on admission were studied for the presence of specific anti-TG Ig M, Ig G antibodies and Ig G avidity using enzyme immunoassay Platelia Toxo Ig M, Ig G. RESULTS: The study showed that 19 children(8 boys, 11 girls; 8-17 years old, mean age 14.36 years) hadhigh serum anti-TG Ig G antibody levels(range: 32.2 > 240 UI/m L, mean 120.18 UI/m L; positive value for Ig G was ≥ 9 UI/m L). The avidity index(AI) ranged from 0.202 to 0.925(scale: ≥ 0.5 high AI). The results for Ig M antibodies were all negative and the obtained results ranged from 0.113 to 0.25 U/m L(mean = 0.191 IU/m L) and all values below 0.8 IU/m L were considered negative. The most frequent complaints found in the seropositive patients were headaches that affected the frontal(13 children), occipital(4) and parietal areas(5). Headaches usually had a pulsating(in 7 patients) and squeezing(6) character and rarely were piercing, dull or expanding. Interestingly, 8 children did not feel discomfort during the headaches, probably because they did not have sufficiently increased intracranial pressure yet. The headaches usually appeared 1-2 times/mo, lasted for 2-6 h, and had a mean intensity of 5.5 points in a 10 point subjective scale. The comorbidities included epilepsy(5 patients), various infections in 3 children(chronic eustachitis, chronic rhinitis, chronic purulent tonsillitis, streptococcal pharyngitis, meningitis, allergic diseases), disturbances of behavior, deficits of attention, and ocular and motor concentration disorders in 1 child. The electroencephalographic and neuroimaging studies performed

关键词： Recurrent headaches Children Seroprevalence of anti-toxoplasma gondii IgG antibodies IgG avidity Chronic toxoplasma gondii infection Cerebral toxoplasmosis

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