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Morphological features of anterior segment:factors influencing intraocular pressure after cataract surgery in nanophthalmos

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Eye and Vision 2020年第2期7卷 454-464页

作者： Qiang Lu Wenwen He Yi Lu Xiangjia Zhu Department of Ophthalmology Eye and EarNoseand Throat HospitalFudan University83 Fenyang RoadShanghai 200031People’s Republic of China Eye Institute Eye and EarNoseand Throat Hospital of Fudan UniversityShanghai 200031People’s Republic of China Key Laboratory of Myopia Ministry of HealthShanghai 200031People’s Republic of China Shanghai Key Laboratory of Visual Impairment and Restoration Shanghai 200031People’s Republic of China

Purpose:To investigate the anterior segment in nanophthalmic eyes and their association with intraocular pressure after cataract ***:Thirty-two nanophthalmic eyes(axial length[AL]anterior segment structures between the two *** associations between the anterior segment characteristics of nanophthalmic eyes and postoperative intraocular pressure(IOP)were also ***:The IOP-lowering effect of cataract surgery was remarkably insufficient in nanophthalmic *** anterior synechiae(PAS)were observed in 56%(18/32)of nanophthalmic eyes,and a characteristic boomerangshaped iris was observed in 28%(9/32).The anterior surface of the iris seemed“smoother”in nanophthalmic eyes than in normal ***’s canal(SC)diameter,SC area,trabecular meshwork(TM)thickness,TM width,and TM area were generally smaller in the nanophthalmic *** age,higher preoperative IOP,broader PAS,and smaller SC area were main contributors to higher postoperative *** and SC diameter may also be of great importance in IOP prediction in patients without glaucoma surgery and ***:The morphological features of the anterior segment in nanophthalmic eyes are significantly different from those of normal *** factors such as age,AL,preoperative IOP,extent of PAS,SC and TM size could all be prognostic for IOP after cataract surgery in nanophthalmic eyes.

关键词： Nanophthalmos anterior segment Intraocular pressure Catara

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Effects of primary selective laser trabeculoplasty on anterior segment parameters

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International Journal of Ophthalmology(English edition) 2015年第5期8卷 954-959页

作者： Suzan Guven Yilmaz Melis Palamar Emil Yusifov Halil Ates Sait Egrilmez Ayse Yagci Department of Ophthalmology Faculty of MedicineEge University

AIMTo investigate the effects of selective laser trabeculoplasty (SLT) on the main numerical parameters of anterior segment with Pentacam rotating Scheimpflug camera in patients with ocular hypertension (OHT) and primary open angle glaucoma (POAG).METHODSPentacam measurements of 45 eyes of 25 (15 females and 10 males) patients (12 with OHT, 13 with POAG) before and after SLT were obtained. Measurements were taken before and 1 and 3mo after SLT. Pentacam parameters were compared between OHT and POAG patients, and age groups (60y and older, and younger than 60y).RESULTSThe mean age of the patients was 57.8±13.9 (range 20-77y). Twelve patients (48%) were younger than 60y, while 13 patients (52%) were 60y and older. Measurements of pre-SLT and post-SLT 1mo were significantly different for the parameters of central corneal thickness (CCT) and anterior chamber volume (ACV) (P0.05).CONCLUSIONSLT leads to significant increase in CCT and decrease in ACV at the 1st month of the procedure. Effects of SLT on these anterior segment parameters, especially for CCT that interferes IOP measurement, should be considered to ensure accurate clinical interpretation.

关键词： anterior segment selective laser trabeculoplasty Pentacam

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Fast segmentation of anterior segment optical coherence tomography images using graph cut

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Eye and Vision 2015年第1期2卷 1-6页

作者： Dominic Williams Yalin Zheng Fangjun Bao Ahmed Elsheikh Ocular Biomechanics and Biomaterials Group School of EngineeringUniversity of LiverpoolBrownlow HillLiverpool L693GHUK Department of Eye and Vision Science University of Liverpool3rd FloorUCD BuildingDaulby StreetLiverpool L693GAUK School of Optometry and Ophthalmology and Eye Hospital Wenzhou Medical UniversityNo.270Xueyuanxi RoadWenzhou CityZhejiang Province 325027China

Background:Optical coherence tomography(OCT)is a non-invasive imaging system that can be used to obtain images of the anterior *** segmentation of these images will enable them to be used to construct patient specific biomechanical models of the human *** models could be used to help with treatment planning and diagnosis of ***:A novel graph cut technique using regional and shape terms was *** was evaluated by segmenting 39 OCT images of the anterior *** results of this were compared with manual segmentation and a previously reported level set segmentation *** different comparison techniques were used:Dice’s similarity coefficient(DSC),mean unsigned surface positioning error(MSPE),and 95%Hausdorff distance(HD).A paired t-test was used to compare the results of different segmentation ***:When comparison with manual segmentation was performed,a mean DSC value of 0.943±0.020 was achieved,outperforming other previously published techniques.A substantial reduction in processing time was also achieved using this ***:We have developed a new segmentation technique that is both fast and *** has the potential to be used to aid diagnostics and treatment planning.

关键词： Optical coherence tomography anterior segment Image segmentation Cornea Graph cut Shape prior

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Consilience and unity in ocular anterior segment research

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1173-1183页

作者： Houmam Araj Department of Health and Human Services National Eye Institute/National Institutes of Health(NEI/NIH)BethesdaMaryland 20892USA

In his beautiful book,Consilience:The Unity of Knowledge,the eminent biologist Edward O Wilson,advocates the need for integration and reconciliation across the *** defines consilience as“literally a‘jumping together’of knowledge with a linking of facts…to create a common groundwork of explanation”.It is the premise of this paper that as much as basic biomedical research is in need of data generation using the latest available techniques–unifying available knowledge is just as *** involves the necessity to resolve contradictory findings,reduce silos,and acknowledge *** take the cornea and the lens as case studies of our ***,in this perspective,we discuss the conflicting and fragmented information on protein aggregation,oxidative damage,and *** are fields of study that are integrally tied to anterior segment *** goal is to highlight the vital need for Wilson’s consilience and unity of knowledge which in turn should lead to enhanced rigor and reproducibility,and most importantly,to greater understanding and not simply knowing.

关键词： anterior segment ocular surface cornea lens cataract posterior capsular opacification protein aggregation oxidative damage antioxidants fibrosis wound healing consilience

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Comparison of anterior segment parameters of the eye between type 2 diabetic with and without diabetic retinopathy and non-diabetic

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International Journal of Ophthalmology(English edition) 2023年第4期16卷 571-578页

作者： Foroozan Narooie-Noori Amir Asharlous Ali Mirzajani Ebrahim Jafarzadehpur Mehdi Behnia Mehdi Khabazkhoob Rehabilitation Research Center Department of OptometrySchool of Rehabilitation SciencesIran University of Medical SciencesTehran ***Iran Noor Research Center for Ophthalmic Epidemiology Noor Eye HospitalTehran ***Iran Department of Basic Sciences School of Nursing and MidwiferyShahid Beheshti University of Medical SciencesTehran ***Iran

AIM:To compare anterior segment parameters between two groups of type 2 diabetic with and without diabetic retinopathy(DR)and non-diabetic elderly subjects based on hemoglobin A1c(Hb A1c)levels and status of ***:This study was conducted on 997 residents aged 60y or over in Tehran,*** group had Hb A1c level≥6.4%with no other systemic *** non-diabetic participants had normal eye findings and no systemic diseases.K1,K2,mean K,Q-value,anterior,central,posterior,and total corneal densitometric findings,anterior chamber volume(ACV),anterior chamber depth(ACD),corneal volume(CV),and pachymetry were measured by Pentacam ***:A total of 678 non-diabetic(39%male)and 319 diabetic(35%male)subjects with mean age of 66.31±5.23 and 67.22±4.96y were examined,*** statistically significant difference was found in anterior segment parameters between non-diabetic and diabetic groups(all P>0.05).However,middle,posterior,and total corneal densitometric values were statistically different between two groups af ter controlling the ef fects of confounders(P=0.014,0.007,and 0.042,respectively).Corneal densitometric values in all layers,ACD,and ACV were different between diabetic subjects with and without DR(all P<0.05).In the diabetic group,only corneal densitometric values had a negative relationship with fasting blood sugar(P<0.001).ACD and ACV had a negative correlation with Hb A1c levels(all P<0.05,r=-0.129 and-0.146,respectively).However,the relationships were not observed after controlling the confounders(P=0.938,0.466,respectively).CONCLUSION:Considering the higher densitometric values of the cornea and lower ACD and ACV in diabetic subjects with DR,it is suggested that the examiners should perform comprehensive retinal examinations when faced with such conditions.

关键词： anterior segment diabetes hyperglycemia retinopathy cornea

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Optical coherence tomography angiography for the anterior segment

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Eye and Vision 2019年第1期6卷 23-31页

作者： Wen Di Lee Kavya Devarajan Jacqueline Chua Leopold Schmetterer Jodhbir S.Mehta Marcus Ang Singapore Eye Research Institute Singapore National Eye CenterSingaporeSingapore Eye-ACP Duke-NUS Graduate Medical SchoolSingaporeSingapore Department of Clinical Pharmacology Medical University of ViennaViennaAustria Center for Medical Physics and Biomedical Engineering Medical University of ViennaViennaAustria Nanyang Technological University SingaporeSingapore

Optical coherence tomography angiography(OCTA)is a rapid and non-invasive technique for imaging vasculature in the *** OCTA can produce high-resolution cross-sectional images and allow depth-resolved analysis for accurate localization of pathology of interest,it has become a promising method for anterior segment ***,OCTA offers a more patient-friendly alternative to the conventional invasive dye-based fluorescent ***,conventional OCTA systems are typically designed and optimized for the posterior segment of the eye,and thus using OCTA for anterior segment imaging can present several difficulties and *** this review,we summarized the recent developments and clinical applications in anterior segment OCTA(AS-OCTA)imaging,such as for the cornea,iris,sclera and *** also compared commercially available OCTA systems,discussed the limitations of adapting current OCTA technology for the anterior segment imaging,and proposed possible future directions for AS-OCTA ***-OCTA provides potential for future clinical applications such as diagnosis of corneal and iris pathologies,pre-operative surgical planning,assessment of new antiangiogenic therapeutics or evaluation of limbal stem cell *** further development,OCTA for anterior segment imaging in the clinics may become common in the near future.

关键词： Optical coherence tomography angiography Vascularisation Cornea Iris anterior segment

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Customized anterior segment photoacoustic imaging for ophthalmic burn evaluation in vivo

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Opto-Electronic Advances 2021年第6期4卷 11-19页

作者： Huangxuan Zhao Ke Li Fan Yang Wenhui Zhou Ningbo Chen Liang Song Chuansheng Zheng Zhicheng Liu Chengbo Liu Department of Radiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Research Laboratory for Biomedical Optics and Molecular Imaging Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China School of Biomedical Engineering Capital Medical UniversityBeijing 100069China Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application Beijing 100069China

Photoacoustic imaging has many advantages in ophthalmic application including high-resolution,requirement of no exogenous contrast agent,and noninvasive acquisition of both morphologic and functional ***,due to the limited depth of focus of the imaging method and large curvature of the eye,it remains a challenge to obtain high quality vascular image of entire anterior ***,we proposed a new method to achieve high quality imaging of anterior *** new method applied a curvature imaging strategy based on only one time scanning,and hence is time efficient and more suitable for ophthalmic imaging compared to previously reported methods using similar strategy.A custom-built photoacoustic imaging system was adapted for ophthalmic application and a customized image processing method was developed to quantitatively analyze both morphologic and functional information in vasculature of the anterior *** results showed that the new method improved the image quality of anterior segment significantly compared to that of conventional high resolution photoacoustic *** importantly,we applied the new method to study ophthalmic disease in an in vivo mouse model for the first *** results verified the suitability and advantages of the new method for imaging the entire anterior segment and the numerous potentials of applying it in ophthalmic imaging in future.

关键词： photoacoustic imaging ophthalmic imaging morphologic and functional information ophthalmic disease anterior segment

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Evaluation of the Changes in anterior segment Morphology with Ultrasound Biomicroscopy after Vitrectomy without Use of Tamponade in Pseudophakic Eyes

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Open Journal of Ophthalmology 2016年第4期6卷 210-220页

作者： Erkan Ünsal Kadir Eltutar Istanbul Research and Training Hospital Istanbul Turkey

Aim: In this study we investigated the changes in anterior segment morphology in pseudophakia patients that underwent ultrasound biomicroscopy (UBM) after pars plana vitrectomy (PPV) operation without use of tamponade. Method: Pseudophakic patients who undergo PPV were enrolled in this prospective study between October 2012 and April 2015. Study included patients in whom intraocular tamponade was not used during PPV operation. UBM measurements were performed both before and 10 days after the operation. anterior chamber depth (ACD) was measured using axial images of anterior segment. Trabecular meshwork-iris angle (TIA), ciliary body thickness (CBT), sclera thickness (ST), trabecular meshwork-ciliary process distance (T-CPD), iris-ciliary processes distance (I-CPD), and iris thickness (IT) were measured at temporal quadrant based on radial section images of the angle. Values measured before and after the operation were statistically compared with each other. Results: This study included 30 patients (18 females, 12 males) that underwent an operation ultrasound biomicroscopy (UBM) after pars plana vitrectomy (PPV) operation without use of tamponade. Mean age was 69.6 ± 9.1 (55 - 85) years. Eighteen operations occurred on the left eye whereas twelve operations occurred on the right eye. CBT1, CBT2, CBT Max, T-CPD, and I-CPD were significantly decreased after operation when compared with the values of baseline (before) (p = 0.018, p = 0.012, p = 0.001, p = 0.033, p = 0.015, respectively). Other evaluated parameters did not show statistically significant changes after the operation (p > 0.05). Discussion: PPV results in significant changes in ciliary body morphology together with changes in anterior segment parameters in pseudophakic cases.

关键词： Ultrasound Biomicroscopy (UBM) Vitrectomy Pseudophakic Eye anterior segment Ciliary Body

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Vessel density and En-face segmentation of optical coherence tomography angiography to analyse corneal vascularisation in an animal model

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Eye and Vision 2019年第1期6卷 6-16页

作者： Kavya Devarajan Wen Di Lee Hon Shing Ong Nyein C.Lwin Jacqueline Chua Leopold Schmetterer Jodhbir S.Mehta Marcus Ang Singapore Eye Research Institute SingaporeSingapore Singapore National Eye Center SingaporeSingapore Eye-ACP Duke-NUS Graduate Medical SchoolSingaporeSingapore Department of Clinical Pharmacology Medical University of ViennaViennaAustria Center for Medical Physics and Biomedical Engineering Medical University of ViennaViennaAustria Nanyang Technological University SingaporeSingapore

Background:Optical coherence tomography angiography(OCTA)is a novel non-invasive angiography technology that has recently been extensively studied for its utility in anterior segment *** this study,we compared a split-spectrum amplitude decorrelation angiography(SSADA)OCTA and an optical micro-angiography(OMAG SD)OCTA system to current angiographic technique,indocyanine green angiography(ICGA),to assess corneal vascularisation in an animal ***:We imaged 16 rabbits,(one eye per animal)with corneal vascularisation using SSADA OCTA(AngioVue;Optovue Inc.,USA),OMAG OCTA(Angioscan;RS-3000 Nidek ***.,Japan)and ICGA in the same region of interest of the cornea at successive *** then analysed all scanned images for vessel density measurements and used paired t-tests and Bland-Altman plots to examine for significant *** en-face segmentation images from each of the OCTA scans were also extracted and were matched at every 50μm segmentation to be compared for vessel density at the respective ***:Bland-Altman plots revealed a good agreement between all three imaging techniques(P>0.05)for all vessel density measurements computed,and the ranges of 95%limit of agreement were acceptable from a clinical *** significant difference was reported,with ICGA(μ=16.52±8.94%)being more comparable to the OMAG OCTA(μ=16.23±9.51%;p=0.50)than the SSADA OCTA(μ=17.09±7.34%;p=0.33)***,a good correlation value(r>0.9)was obtained when comparing the vessel density measurements of the en-face segmentations between the OCTA ***:Comparable vessel density quantification between the two OCTA systems,and with ICGA was *** analysis of the vasculature at different depths showed varied performance in the two OCTA systems relative to each *** implications of the study may help to aid in the development of better OCTA algorithms for the anterior segment and its use in clinical translational research.

关键词： OCTA Corneal vascularisation Optical micro angiography Split-spectrum amplitude decorrelation angiography Vessel density anterior segment En-face OCTA

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Quantitative analysis of conjunctival microvasculature imaged using optical coherence tomography angiography

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Eye and Vision 2019年第1期6卷 32-40页

作者： Zhiping Liu Hua Wang Hong Jiang Giovana Rosa Gameiro Jianhua Wang Ophthalmic Center the Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina Department of Ophthalmology Bascom Palmer Eye InstituteUniversity of Miami Miller School of Medicine1638 NW 10th AvenueMcKnight Building-Room 202AMiamiFL 33136USA. Department of Ophthalmology Xiangya HospitalCentral South UniversityChangshaHunanChina

Background:The goal was to quantitatively analyze the bulbar conjunctival microvascular density using optical coherence tomography angiography(OCTA)and compare it to the vessel density using functional slit-lamp biomicroscopy(FSLB).Methods:Temporal bulbar conjunctiva of 20 eyes(10 healthy subjects)was imaged using both OCTA and *** processing was performed including equalization,de-noising,thresholding,and *** vessel density was measured by fractal analysis(box counting,Dbox)and pixel counting(%).Results:Vessel density(Dbox)of the bulbar conjunctiva obtained using OCTA was 1.28±0.01 Dbox,which was significantly lower than the result(1.32±0.01 Dbox,P0.05)between both instruments were found in both vessel density methods(Dbox and percentage).However,in each of the devices,vessel density in Dbox was significantly correlated with the vessel density in percentage(r=1.0 for FSLB and r=0.98 for OCTA,both P<0.001).Conclusion:This study demonstrated that the vessel density of the bulbar conjunctiva obtained using OCTA can be quantified,and the results were not compatible with that obtained using slit-lamp biomicroscopy photography.

关键词： Conjunctival microvasculature Optical coherence tomography angiography(OCTA) Functional slit lamp bio-microscopy(FSLB) anterior segment

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