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Role of PIVKA-ii in screening for malignancies at a hepatobiliary andpancreatic disease center: A large-scale real-world study

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iLIVER 2022年第4期1卷 209-216页

作者： Chenghao Ge Mingjie Luo Kaiyuan Guo Dong Zhu Ning Han Tengjiao Wang Xiuying Zhao Department of Clinical Laboratory Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China Tsinghua Clinical Research Institute Tsinghua UniversityBeijing 100084China School of Medicine Tsinghua UniversityBeijing 100084China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhouGuangdong 510060China

Background and aims:Protein induced by vitamin K absence or antagonist ii(PIVKA-ii)is a well-accepted biomarker for diagnosing hepatocellular carcinoma(HCC).Although nonspecific increase of PIVKA-ii has been reported,real-world evidence remains *** on real-world data,this study aimed to comprehensively describe the use of PIVKA-ii at a hepatobiliary and pancreatic disease center and to assess its utility for the initial screening of HCC or other hepatobiliary–pancreatic ***:This real-world retrospective study is based on the PIVKA-ii results of 16,215 individuals and other relevant laboratory test(alpha-fetoprotein[AFP],carbohydrate antigen 19-9[CA19-9],liver function,blood coagulation indicators,hepatitis B virus,and hepatitis C virus).However,only the first PIVKA-ii results of 7809 eligible individuals were ***-group comparisons,correlation analysis,and receiver operating characteristic curve analysis were ***:PIVKA-ii results were abnormal in patients with HCC(55.9%),biliary carcinoma(BC,13.4%),gastroin-testinal and pancreatic cancer(6.3%),and benign diseases(23.5%)as well as in healthy individuals(0.92%).The area under the curve of PIVKA-ii for detecting malignancies was 0.7754(0.7620–0.7688),whereas that for detecting HCC was 0.7509(0.7357–0.7662).Stratifying the PIVKA-ii values or combining PIVKA-ii with AFP or CA19-9 helped improve the diagnostic performance of PIVKA-ii for ***-ii values were significantly positively correlated with AST in patients with HCC and with bilirubin in patients with ***:This study determined the role of PIVKA-ii in malignancy screening at hepatobiliary and pancreatic disease *** was also noted that the diagnostic efficacy of PIVKA-ii for HCC improved after combining PIVKA-ii with AFP or stratifying its value.

关键词： Protein induced by vitamin K absence Or antagonist ii Hepatocellular carcinoma Hepatobiliary and pancreatic diseases Real-world study

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