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Aligned 3D porous polyurethane scaffolds for biological anisotropic tissue regeneration

Regenerative Biomaterials 2020年第1期7卷 19-27页

作者： Weiwei Lin Wanling Lan Yingke Wu Daiguo Zhao Yanchao Wang Xueling He Jiehua Li Zhen Li Feng Luo Hong Tan Qiang Fu College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China Sichuan Institute for Food and Drug Control Chengdu 611731China Department of Neurosurgery West China Hospital Sichuan UniversityChengdu 610065China Laboratory Animal Center of Sichuan University Chengdu 610041China

A green fabrication process(organic solvent-free)of artificial scaffolds is required in tissue engineering *** this work,a series of aligned three-dimensional(3D)scaffolds are made from biodegradable waterborne polyurethane(PU)emulsion via directional freeze–drying method to ensure no organic *** optimizing the concentration of polymer in the emulsion and investigating different freezing temperatures,an aligned PUs scaffold(PU14)generated from 14wt%polymer content and processed at196C was selected based on the desired oriented porous structure(pore size of 32.569.3 lm,porosity of 92%)and balanced mechanical properties both in the horizontal direction(strength of 41.3 kPa,modulus of 72.3 kPa)and in the vertical direction(strength of 45.5 kPa,modulus of 139.3 kPa).The response of L929 cells and the regeneration of muscle tissue demonstrated that such pure material-based aligned 3D scaffold can facilitate the development of orientated cells and anisotropic tissue regeneration both in vitro and in ***,these pure material-based scaffolds with ordered architecture have great potentials in tissue engineering for biological anisotropic tissue regeneration,such as muscle,nerve,spinal cord and so on.

关键词： polyurethane aligned scaffolds tissue engineering anisotropic regeneration

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