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Magnetic resonance imaging of hepatocellular carcinoma induced by diethylnitrosamine in Sprague-Dawley rats

Hepatobiliary & Pancreatic Diseases International 2005年第3期4卷 427-432页

作者： Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China (Li X, Zhou XP and Guan YS) Department of Radiology, Ruijin Hospieal. Shanghai Second Medical University, Shanghai 200025 , China. Current address:Astra Zeneca R & D Alderley, Macclesfield SK 10 4 TG U. K. (Wang YX) Department of Radiology West China Hospital Sichuan University Chengdu 610041 China.

Diethylnitrosamine (DENA) is able to induce various benign and malignant liver lesions in rats with a high success rate and a low mortality rate. It provides a more appropriate model that better simulates the various lesions occurring in humans than the usual model of tumor implantations. The aim of the present study was to evaluate MRI liver examination in Sprague-Dawley(SD) rats as a routine method to detect hepatocellular carcinoma (HCC) nodules induced by DENA and to follow up their growth. METHODS:Hepatic carcinogenesis was induced in 80 male SD rats using oral DENA solution. All animals were imaged for liver tumor detection with a 1.5 Tesla magnet (Siemens Sonata,Erlangen, Germany) using correspondence scan parameters and a radio-frequency knee coil. Macroscopic examinations were performed along the axial MRI sections to evaluate magnetic resonance imaging (MRI) findings, and histopathological assessment was also performed. RESULTS:No false negative results were obtained on MR images. Hepatic tumors in 72 rats were confirmed macro-scopically and 68 rats were detected by MRI till the 20th week. The smallest and the largest nodules detected by MRI were 2 mm and 37 mm in diameter respectively. The agreement rate of MRI with macroscopic observation was 39. 1% and 97. 4% respectively for 2 mm to 5 mm and more than 5 mm nodules. CONCLUSIONS:The hepatic tumor induced by DENA provides a more representative range of tumors for imaging diagnosis and interventional treatment. MRI is the best approach for scrutinizing pathological changes of rat livers in the period of observation.

关键词： animal-model hepatocellular carcinoma Sprague-Dawley rat magnetic resonance imaging

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EXPERIMENTAL STUDIES ON CENTRAL BENZODIAZEPINE RECEPTORS IN THE BRAINS OF HEPATIC ENCEPHALOPATHY RATS

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中华医学杂志(英文版) 1993年第10期106卷 723-727页

作者：张宗明陈孝平裘法祖 Department of Surgery Tongji HospitalTongji Medical University

With radioligand binding assay, we studied the central benzodiazepine receptors （CBR） in the different regions of brain including the telencephaion, diencephalon, brain stem and cerebellum in a rat model of hepatic encephalopathy （HE） induced by partial hepatectomy following carbon tetrachioride （CC1） intoxication and in the controls. Affinities （Kd） and densities （Bmax） of [H]-flunitrazepine binding to crude synaptic membranes in the telencephalon of HE rats were obviously increased as compared with those of the controls. It was only in the diencephalon, the brain stem and the cerebellum of HE rats that increased Bmax values were observed, while the Kd values remained unchanged. The results support the recent suggestion that the alterations of CBR play a significant role in the pathogenesis of HE. Among the ranges of the alterations of CBR in the HE rats, the telencephalon ranked first, the brain stem second, the cerebellum third, and the diencephalon last.

关键词： CEREBROSPINAL-FLUID animal-model FAILURE ACID

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Gene environment interaction in periphery and brain converge to modulate behavioral outcomes:Insights from the SP1 transient early in life interference rat model

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World Journal of Psychiatry 2016年第3期6卷 294-302页

作者： Eyal Asor Dorit Ben-Shachar Laboratory of Psychobiology Department of PsychiatryRambam Medical Center and B.Rappaport Faculty of MedicineRappaport Family Institute for Research in the Medical Sciences

It is generally assumed that behavior results from an interaction between susceptible genes and environmental stimuli during critical life *** present article reviews the main theoretical and practical concepts in the research of gene environment interaction,emphasizing the need for models simulating real life *** review a novel approach to study gene environment interaction in which a brief post-natal interference with the expression of multiple genes,by hindering the activity of the ubiquitous transcription factor specificity protein 1(Sp1) is followed by later-in-life exposure of rats to ***,this review discusses the role of peripheral processes in behavioral responses,with the Sp1 model as one example demonstrating how specific behavioral patterns are linked to modulations in both peripheral and central physiological *** suggest that models,which take into account the tripartite reciprocal interaction between the central nervous system,peripheral systems and environmental stimuli will advance our understanding of the complexity of behavior.

关键词： Gene-environmental interaction Specificity protein 1 Mithramycin Stress animal-model Essential amino acids Tryptophan Insulin

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