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Remodel the perifollicular microenvironment via Minoxidil-loaded microneedle patch and cold atmospheric plasma for treating androgenetic alopecia

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Nano Research 2024年第7期17卷 6411-6419页

作者： Hao Chen Xianzhe Tang Yueye Huang Chen Chen Yuheng Yang Chaojie Hao Wenqi Xie Tingjing Huang Xiaofeng Cheng Qingnan Xu Shicong Huang Zhi Ye Xucong Lin Zhaowei Chen Zhitong Chen MOE Key Laboratory for Analytical Science of Food Safety and Biology and New Cornerstone Science LaboratoryCollege of ChemistryFuzhou UniversityFuzhou 350108China Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Advanced Therapeutic Center National Innovation Center for Advanced Medical DevicesShenzhen 518000China Department of Chemistry University College LondonLondon WC1H 0AJUK Engineering Technology Research Center on Reagent and Instrument for Rapid Detection of Product Quality and Food Safety in Fujian Province College of ChemistryFuzhou UniversityFuzhou 350108China Key Laboratory of Biomedical Imaging Science and System Chinese Academy of SciencesShenzhen 518055China

androgenetic alopecia(AGA)is a chronic and progressive form of hair loss characterized by vascular degeneration in the perifollicular microenvironment,leading to cell apoptosis and eventual loss of hair follicles(HFs).Traditional therapeutic formulations,such as Minoxidil(MXD)tincture,have limitations in reshaping the perifollicular microenvironment and exhibit limited ***,we report a multi-synergistic therapeutic platform for high-performance hair regeneration *** platform combines microneedle(MN)patches loaded with MXD-encapsulated nanostructured lipid carriers(MXD-NLC-MNs)and cold atmospheric plasma(CAP).The MNs’mechanical strength enables efficient transdermal delivery of MXD to the targeted dermal papilla cells,promoting cell ***,in collaboration with MXD,the mechanical stimulation exerted by MN application synergistically upregulates the expression of vascular endothelial growth factor,leading to ***,the transient microchannels in the skin created by MNs facilitate the transdermal delivery of CAPgenerated nitric oxide(NO)to the sites of HF lesions,whereby the synergistic interaction between MXD and NO boosts perifollicular ***,the perifollicular microenvironment can be effectively reshaped to accelerate hair regeneration in AGA murine *** multi-synergistic combination therapy strategy would hold great promise for effectively treating AGA and promoting hair regrowth.

关键词： nanomedicine androgenetic alopecia microneedle cold atmospheric plasma drug delivery

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Psychological stress impact neurotrophic factor levels in patients with androgenetic alopecia and correlated with disease progression

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World Journal of Psychiatry 2024年第10期14卷 1437-1447页

作者： Yi Cheng Li-Jing Lv Yu Cui Xiao-Mei Han Yan Zhang Cai-Xia Hu Department of Dermatology The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina

BACKGROUND androgenetic alopecia(AGA)is a common form of hair loss that can be influenced by psychological *** To investigate the impact of mental stress on neurotrophic factors in patients with AGA and correlate the findings with the progression of *** A total of 120 patients with AGA were analyzed in this study,which were divided into a non-stress group(n=30)and a stress group(n=90)on the basis of the presence or absence of psychological stress confirmed by Depression Anxiety Stress Scale-21 *** baseline demographic characteristics,serum cortisol levels,hair growth parameters,neurotrophic factors,and AGA progression scores between the non-stress and stress groups were *** analyses were conducted to assess the relationships among stress,neurotrophic factors,hair loss progression,and AGA *** This study revealed significantly higher cortisol levels throughout the day in the stress group than in the non-stress *** stress group exhibited lower levels of nerve growth factor,brain-derived neurotrophic factor,and glial cell linederived neurotrophic factor and higher expression levels of neurotrophin(NT)-3 and NT-4 than the non-stress *** parameters indicated lower hair diameter,decreased hair density,and more severe AGA grading in the stress group,whereas follicle count and terminal/vellus hair ratio showed no significant differences between the two *** 1 year of treatment with 5%minoxidil,efficacy was observed to be lower but AGA progression was notably more pronounced in the stress group than in the non-stress *** progression was positively correlated with high stress and NT-4 *** This study provides compelling evidence of the influence of mental stress on neurotrophic factors and its correlation with the progression of *** findings underscore the need for a comprehensive approach to the management of AGA that considers the physiological and psychosocial ***

关键词： Mental stress Neurotrophic factors androgenetic alopecia Progression

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Defective Expression of the Gap Junction Protein Pannexin-1 Channel Contributes to the Formation of PCOS-Realted androgenetic alopecia

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Advances in Reproductive Sciences 2023年第4期11卷 86-92页

作者： Sule Gencoglu Fatma Tanilir Cagiran Zercan Kali Dermatology Private G&oumlzde Akademi Hospital Malatya Turkiye Private Clinic Obstetrics and Gynecology Diyarbakir Turkey Gozde Academy Hospital Obstetrics and Gynecology Malatya Turkey

Objective: To determine serum pannexin-1 channel levels and their association with hair loss in women with PCOS diagnosed with female androgenetic alopecia (FAGA). Materials and Methods: Thirty-five women with PCOS who presented with diffuse and treatment-resistant progressive hair loss and were diagnosed with FAGA were included in the study. 25 patients who were diagnosed with female androgenetic alopecia but did not have PCOS were considered as the control group. PCOS and control groups were matched by age. Follicular miniaturization, displacement of terminal hairs with vellus hairs, and a diffuse decrease in hair density were accepted as FAGA in the trcihoscopy examination of the vertex and bitempoaral area. On the third day of the menstrual cycle serum FSH, LH, testosterone, PRL and insulin levels were measured. Insulin resistance was calculated with HOMA-IR. Serum pannexin-1 channel levels of each group were mesured with ELISA. Results: Serum pannexin 1 channels levels of FAGA group due to PCOS were found to be significantly higher than FAGA patients in the control group (2.72 ± 1.09 ng/mL vs 1.65 ± 0.97 ng/mL, p 2.5 in the PCOS group compared to the controls. PRL values were similar except for one patient with elevated PRL. Serum FSH values were the same in both groups. A positive and significant correlation was found between pannexin 1 channels levels and HOMA-IR and serum testosterone levels (r = 0.650, p Conclusions: In addition to hyperandrogenemia, increased pannexin 1 channel levels may play a role in the etiology of PCOS associated FAGA, as it impairs the communication between the skin and hair follicle.

关键词： androgenetic alopecia PCOS Androgen Pannexin-1 Channel Inflammation

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Effectiveness of Chuzhi Shengfa Tablets Combined with Ketoconazole Shampoo and Chuzhi Shengfa Tablets Combined with 5%Minoxidil Foam in the Treatment of Male androgenetic alopecia

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Journal of Clinical and Nursing Research 2024年第9期8卷 201-207页

作者： Jianming Wei Yu Li Li Zhang Rui Wang Lu Chen Jiaojiao Zhao Jia Li Department of Dermatology the Fifth Medical Center of PLA General HospitalBeijing 100071China Department of Dermatology the First Medical Center of PLA General HospitalBeijing 100853China

Objective:To investigate the clinical efficacy and safety of Chuzhi Shengfa Tablets combined with ketoconazole shampoo and Chuzhi Shengfa Tablets combined with 5%minoxidil foam in the treatment of male androgenetic ***:From July 2022 to July 2023,120 male patients with androgenetic alopecia were selected from our Department of Dermatology and randomly divided into Control Group 1,Control Group 2,Observation Group 1,and Observation Group 2,with 30 patients in each *** Group 1 was treated with ketoconazole shampoo,Control Group 2 with 5%minoxidil foam,Observation Group 1 with ketoconazole shampoo combined with Chuzhi Shengfa Tablets,and Observation Group 2 with 5%minoxidil foam combined with Chuzhi Shengfa *** density,hair diameter,scalp oil secretion(using oil secretion scoring),and adverse reactions were compared before and after treatment across the four ***:After treatment,hair density and hair diameter significantly increased in all four groups compared to before treatment,while scalp oil secretion scores significantly decreased(P0.05).Conclusion:Chuzhi Shengfa Tablets combined with ketoconazole shampoo and Chuzhi Shengfa Tablets combined with 5%minoxidil foam are both effective and safe for treating male androgenetic *** combinations can significantly improve hair growth and are worthy of clinical promotion.

关键词： Chuzhi Shengfa Tablets Ketoconazole shampoo Minoxidil foam Male androgenetic alopecia

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Evaluation of the Clinical Efficacy of Chuzhi Shengfa Tablets and Finasteride in the Treatment of androgenetic alopecia

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Journal of Clinical and Nursing Research 2024年第9期8卷 47-52页

Objective:To explore the clinical efficacy and safety of Chuzhi Shengfa tablets combined with finasteride in the treatment of male androgenetic alopecia(AGA).Methods:Sixty male patients with androgenetic alopecia admitted to our Department of Dermatology between January 2022 and January 2024 were randomly divided into two groups,with 30 patients in each *** control group was treated with finasteride,while the observation group received a combination of Chuzhi Shengfa tablets and *** clinical efficacy and adverse reactions in both groups were ***:The overall effectiveness rate in the observation group was 93.33%(28/30),significantly higher than the control group’s 73.33%(22/30),with a statistically significant difference(P0.05).Conclusion:The combination of Chuzhi Shengfa tablets and finasteride shows good clinical efficacy in treating male androgenetic ***,Chuzhi Shengfa tablets are convenient to administer and effectively improve efficacy,significantly improving patients’conditions,and demonstrating good clinical application value.

关键词： Chuzhi Shengfa tablets Finasteride androgenetic alopecia

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Platelet-Rich Plasma for androgenetic alopecia in Women: A Single-Center Case Series Study in Qatar

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International Journal of Dermatology and Venereology 2020年第4期3卷 228-230页

作者： Syed Mohamed Ahmed Abushaikha Samya Sami A.S. Department of Clinical Research Primary Health Care CorporationP.O.Box 26555 DohaQatar Department of Dermatology Rumailah HospitalP.O.Box 3050 DohaQatar

Objective:androgenetic alopecia (AA) is a progressive hair loss disorder mediated by systemic androgens and genetic factors. A variety of AA treatments have been investigated. Currently, there is emerging evidence and growing interest in the use of platelet-rich plasma (PRP) for AA. This study describes a single-center experience using PRP to treat AA in ***:A retrospective observational study design was employed. The study cohort comprised 20 women >18 years of age who were diagnosed with AA. PRP was prepared using a commercially available PRP kit. Each patient received six PRP treatment sessions at 4-week intervals. The severity of alopecia tool (SALT) scoring system was used to measure the severity of alopecia, and a paired t-test was used to calculate significance levels. Results:The mean pre-intervention and post-intervention total SALT score was 27.5 ± 6.35 and 9.41 ± 3.71, respectively. The difference in the total mean SALT score was 18.33 ± 1.64 and the effect size was 3.52. The scalp area with the largest effect size was the vertex (Cohen d= 2.53). The effect size was similar across other scalp areas (Cohen d= 1.91-2.09). There were no serious adverse effects of the treatment;only mild transient adverse effects were reported. Conclusion:The present study demonstrated the efficacy and safety of PRP injections in treating AA in women. However, these findings require confirmation in well-designed studies using standardized treatment protocols and evaluation methods.

关键词： androgenetic alopecia case series platelet-rich plasma Qatar

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Nitric oxide synergizes minoxidil delivered by transdermal hyaluronic acid liposomes for multimodal androgenetic-alopecia therapy

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Bioactive Materials 2024年第2期32卷 190-205页

作者： Hui Xing Huanqi Peng Yuhui Yang Kai Lv Shihao Zhou Xiangjun Pan Jianjin Wang Yunfeng Hu Guowei Li Dong Ma The First Affiliated Hospital of Jinan University Jinan UniversityGuangzhou510630China Key Laboratory of Biomaterials of Guangdong Higher Education Institutes Department of Biomedical EngineeringJinan UniversityGuangzhou510632China Honest Medical China Co. LtdZhuhai519000China Department of Nuclear Medicine and PET/CT-MRI Center The First Affiliated Hospital of Jinan UniversityJinan UniversityGuangzhou510630China MOE Key Laboratory of Tumor Molecular Biology Jinan UniversityGuangzhou510632China

androgenetic alopecia(AGA)is a common clinical condition,affecting over 200 million people globally each *** decades,Minoxidil(Mi)tincture has been the primary treatment for this disease,but its low utilization rate and significant side effects necessitate new therapeutic *** oxide(NO)is a signaling molecule in various physiological processes,including vasodilation,immune responses,and cell ***,we constructed a hyaluronic acid liposome(HL)complex as a novel transdermal delivery system(HL@Mi/NONOate)for NO and Mi,which displayed promising transdermal and hair-regrowth ***-depth mechanistic studies revealed three potential pathways of the synergistic AGA ***,NO promoted capillary dilation and accelerated blood flow,thus achieving efficient penetration of *** to the structural advantage of liposomes,the residence time of the Mi in the skin was ***,HL@Mi/NONOate promoted cell proliferation and angiogenesis,and upregulated the expression of regulatory factors involved in follicle stem cell *** the AGA model,HL@Mi/NONOate down-regulated the expression of inflammatory factors,inhibiting the inflammation of follicle and improving the microenvironment of hair ***,HL@Mi/NONOate upregulated the expression of Ki67 and PCNA proteins in follicle tissues,inducing follicle regeneration and development,ultimately achieving the synergistic multimodal AGA therapy.

关键词： Nitric oxide Liposome Enhanced penetration Synergistic therapy androgenetic alopecia

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Sexual,physical and overall adverse effects in patients treated with 5a-reductase inhibitors:a systematic review and meta-analysis

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Asian Journal of Andrology 2022年第4期24卷 390-397页

作者： Jun-Jie Zhang Xiao Shi Ting Wu Meng-Da Zhang Jin Tang Guang-Ming Yin Zhi Long Le-Ye He Lin Qi Long Wang Department of Urology The Third Xiangya HospitalCentral South UniversityChangsha 410008China Department of Urology Xiangya HospitalCentral South UniversityChangsha 410013China Department of Gastroenterology The Third Xiangya HospitalCentral South UniversityChangsha 410013China Department of Cardiovascular Medicine The Third Xiangya HospitalCentral South UniversityChangsha 410013China

Postfinasteride syndrome(PFS)is a term coined to characterize a constellation of reported undesirable sexual,physical,and neuropsychiatric side *** the present study,we conducted the meta-analysis to demonstrate whether the use of 5α-reductase inhibitors(5ARIs)increases the risk of PFS-like adverse effects.A search of studies published until May 10,2020,was performed using PubMed,EMBASE,and the Cochrane *** included randomized controlled trials with at least one comparison between male patients receiving 5ARIs versus placebo for the treatment of benign prostatic hyperplasia(BPH)or androgenetic alopecia(AGA),and identified 34 studies from 28 articles that met our eligibility *** the random-effects model,the overall use of 5ARIs exhibited a 1.87-fold risk of PFS-like adverse effects during the trial(95%confidence interval[CI]:1.64-2.14).Regarding specific types of adverse effects,the use of 5ARIs had a 1.89-fold risk of sexual adverse effects(95%CI:1.74-2.05)and was associated with an increased risk of physical adverse effects(relative risk[RR]:1.31,95%CI:0.80-2.15),albeit without statistical *** meta-analysis helped to better define the adverse effects caused by *** concluded that the overall use of 5ARIs significantly increased the risk of PFS-like adverse effects in men with AGA or BPH during *** awareness of and education on the PFS-like adverse effects are necessary for clinicians.

关键词： 5α-reductase inhibitors adverse effects androgenetic alopecia benign prostatic hyperplasia postfinasteride syndrome

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Hair follicle-targeting drug delivery strategies for the management of hair follicle-associated disorders

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Asian Journal of Pharmaceutical Sciences 2022年第3期17卷 333-352页

作者： Yueting Gu Qiong Bian Yanjun Zhou Qiaoling Huang Jianqing Gao Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Zhejiang Huanling Pharmaceutical Technology Company Jinhua 321000China The Third People’s Hospital of Hangzhou Hangzhou 310009China Jiangsu Engineering Research Center for New-type External and Transdermal Preparations Changzhou 213149China

The hair follicle is not only a critical penetration route in percutaneous absorption but also has been recognized to be a target for hair follicle-associated disorders,such as androgenetic alopecia(AGA)and acne *** follicle-targeting drug delivery systems allow for controlled drug release and enhance therapeutic efficacywithminimal side effects,exerting a promising method for themanagement of hair follicle-associated ***,they have obtained much attention in several fields of research in recent *** review gives an overviewof potential follicle-targeting drug delivery formulations currently applied based on the particularities of the hair follicles,including a comprehensive assessment of their preclinical and clinical performance.

关键词： Follicular drug delivery androgenetic alopecia Acne vulgaris Nanotechnology Microneedles

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Regulation and dysregulation of hair regeneration: aiming for clinical application

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Cell Regeneration 2022年第1期11卷 203-211页

作者： Zhicao Yue Fang Yang Jianglin Zhang Ji Li Cheng-Ming Chuong Department of Cell Biology and Medical Genetics International Cancer Centerand Guangdong Key Laboratory for Genome Instability and Disease PreventionShenzhen UniversityA7-455 XiLi CampusShenzhen 518060GuangdongChina Department of Dermatology Shenzhen People’s HospitalThe Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and TechnologyShenzhenGuang-dongChina Department of Dermatology Xiangya HospitalCentral South UniversityChangshaChina Department of Pathology University of Southern CaliforniaLos AngelesCAUSA

Hair growth and regeneration represents a remarkable example of stem cell *** progress emphasizes the micro-and macro-environment that controls the regeneration *** is a shift from a stem cell-centered view toward the various layers of regulatory mechanisms that control hair regeneration,which include local growth factors,immune and neuroendocrine signals,and dietary and environmental *** is better suited for clinical applica-tion in multiple forms of hair disorders:in male pattern hair loss,the stem cells are largely preserved,but androgen signaling diminishes hair growth;in alopecia areata,an immune attack is targeted toward the growing hair follicle without abrogating its regeneration ***-wide association studies further revealed the genetic bases of these disorders,although the precise pathological mechanisms of the identified loci remain largely *** analyzing the dysregulation of hair regeneration under pathological conditions,we can better address the complex interactions among stem cells,the differentiated progeny,and mesenchymal components,and highlight the critical role of macroenvironment adjustment that is essential for hair growth and *** poly-genetic origin of these disorders makes the study of hair regeneration an interesting and challenging field.

关键词： Hair follicle Stem cells Regeneration androgenetic alopecia alopecia areata

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