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Acute leukemic phase of anaplastic lymphoma kinase-anaplastic large cell lymphoma: A case report and review of the literature

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World Journal of Clinical Cases 2020年第21期8卷 5439-5445页

作者： Huai-Feng Zhang Yan Guo Department of Hematology The First Affiliated Hospital of Shandong First Medical UniversityJinan 250014Shandong ProvinceChina

BACKGROUND anaplastic large cell lymphoma(ALCL)is a rare and heterogeneous malignant tumor,which is classied as anaplastic lymphoma kinase(ALK)positive ALCL and *** patients are diagnosed with ALCL at the stage of bone marrow ***,ALCL patients with clinical manifestations consistent with acute leukemia are relatively *** SUMMARY In this report,the patient did not receive appropriate diagnosis and treatment despite a two-year history of lymph node ***,she was admitted for B symptoms and was diagnosed as ALK-ALCL by lymph node ***,the disease progressed to leukemia without any treatment after 2 *** proportion of lymphoma cells in bone marrow was as high as 96%,and the proportion of peripheral blood was 84%.She also had clinical manifestations similar to acute *** completion of chemotherapy,she developed granulocytopenia and fever and died from *** ALCL with leukemic presentation is a late manifestation of lymphoma with low chemotherapy tolerance and poor prognosis.

关键词： anaplastic large cell lymphoma anaplastic lymphoma kinase Prognosis Leukemic phase Case report

Primary cutaneous anaplastic large cell lymphoma with overexpressed Ki-67 transitioning into systemic anaplastic large cell lymphoma:A case report

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World Journal of Clinical Cases 2023年第28期11卷 6889-6894页

作者： Hai-Xi Mu Xiao-Qiong Tang Department of Hematology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China

BACKGROUND Primary cutaneous anaplastic large cell lymphoma(PC-ALCL)differs from systemic anaplastic large cell lymphoma(sALCL)in cell biological behavior,clinical features,treatment,and ***-ALCL has been reported to rarely transition into sALCL,but the underlying mechanism is not *** we report such a case with certain characteristics that shed light on *** SUMMARY Herein,we report a 43-year-old male with symptoms of a skin nodule and histologically confirmed PC-ALCL with high expression of *** three months of observation,two skin nodules re-appeared with muscle layer involvement and was histologically confirmed as *** months after receiving six cycles of CHOP regimen,the patient had pain in the chest and back,cough,shortness of breath,and night *** was confirmed as relapse of sALCL by immunohistochemistry and several organs,such as the lung were involved as shown by positron emission tomography/computed *** four cycles of DICE plus chidamide regimens followed by auto-hematopoietic stem cell transplantation(ASCT),complete remission(CR)duration was achieved for twelve months while the patient was on maintenance with chidamide(20 mg)*** This case had significantly high expression of Ki-67 when diagnosed as PC-ALCL initially and then transitioned into sALCL,which is ***-ASCT combined with demethylation drugs effectively maintained CR and prolonged progression free survival.

关键词： Cutaneous lymphoma anaplastic large cell lymphoma Ki-67 Auto hematopoietic stem cell transplantation Case report

Neutrophil rich anaplastic large cell lymphoma presented as cutaneous nodules in an adolescent

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Chinese Medical Journal 2008年第3期121卷 283-285页

作者： DU Hua-ping JIANG Hao WANG Yi-hong HUANG Jin-wen Department of Hematology Sir Run Run Shaw Hospital School ofMedicine Zhejiang University Hangzhou Zhejiang 310016China

anaplastic large cell lymphoma （ALCL）, a type of lymphoma, was first described by Stain in 1985 and included in non-Hodgkin lymphoma according to REAL classification since 1998. In the absence of necrosis, neutrophils infiltration in non-Hodgkin lymphoma is uncommon. Mann et alI had previously reported neutrophil rich ALCL as a variant of ALCL. In this paper, we describe a neutrophil rich, anaplastic large cell lymphoma （ALCL） which presented as cutaneous nodules in an adolescent.

关键词： anaplastic large cell lymphoma neutrophil

Primary tracheobronchial anaplastic large cell lymphoma in an 8-year-old child presenting with asthma-like symptoms

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Chinese Medical Journal 2014年第4期127卷 794-795页

作者： Shi H Han YP Bai C Li Q He MX Huang L Ma DL Department of Respiratory Medicine Changhai Hospital Second Military Medical University Shanghai 200433 China Department of Pathology Changhai Hospital Second Military Medical University Shanghai 200433 China

Primary tracheobronchial anaplastic large cell lymphoma （ALCL） is very *** spite of its rarity,tracheobronchial tumor can cause life-threatening airway obstruction because of its growing site and biological *** we r... 详细信息

关键词： anaplastic large cell lymphoma trachealbronchial anaplastic lymphoma kinase

Primary bone anaplastic lymphoma kinase positive anaplastic largecell lymphoma: A case report and review of the literature

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World Journal of Clinical Cases 2021年第14期9卷 3403-3410页

作者： Wei Zheng Qiao-Qiao Yin Tian-Chen Hui Wen-Hao Wu Qing-Qing Wu Hai-Jun Huang Mei-Juan Chen Rong Yan Yi-Cheng Huang Hong-Ying Pan Department of Infectious Diseases Zhejiang Provincial People’s Hospital People’s Hospital of Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina The Graduate School Bengbu Medical CollegeBengbu 233030Anhui ProvinceChina The Graduate School Qingdao UniversityQingdao 266071Shandong ProvinceChina The Second School of Clinical Medicine Zhejiang Chinese Medicinal UniversityHangzhou 310053Zhejiang ProvinceChina

BACKGROUND Primary bone lymphoma(PBL)is an uncommon extranodal disease that represents approximately 1%-3%of *** lymphoma kinase(ALK)positive anaplastic large-cell lymphoma(ALCL)is an extremely rare type of *** aim of this report is describe the symptoms,diagnosis,and treatment of primary bone ALK-positive *** SUMMARY A 66-year-old man presented to our hospital with neck and shoulder pain and intermittent fever that lasted for 1 *** extensive evaluation,positron emission tomography-computed tomography(CT)examination showed multiple osteolytic bone lesions without other sites ***-guided biopsy of the T10 vertebral body was performed,and the pathology results showed that neoplastic cells were positive for ALK-1,CD30,and CD3.A diagnosis of primary bone ALK positive ALCL was ultimately *** patient was in partial response after four cycle soft cyclophosphamide,doxorubicin,vincristine,and prednisone chemotherapy,and we planned to repeat the biopsy and radiological examination after completion of the fifth cycle of *** Primary bone ALK positive ALCL is a rare disease and physicians should keep in mind that ALCL can present with isolated osseous involvement without nodal involvement,and lymphoma should be considered in the differential diagnosis of primary bone lesions.

关键词： anaplastic large cell lymphoma anaplastic lymphoma kinase Primary bone lymphoma Bone involvement Osteolysis Case report

Pathogenesis,presentation and classification of late autoinflation of the breasts:case report and literature search

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Plastic and Aesthetic Research 2016年第1期3卷 31-35页

作者： Umar Daraz Khan Aesthetic Plastic Surgeon Reshape HouseWest MallingKent ME196QRUK.

Aim:Autoinflation of the breast following mammoplasty using breast implants can be divided into early and *** autoinflation of the breast is commonly due to *** autoinflation of the breast is an uncommon complication and its true incidence is not known due to the paucity of its ***:A retrospective review was performed of the available charts for 2,772 consecutive bilateral primary,secondary augmentation mammoplasties and mastopexy with augmentation mammoplasties by the author between April 1999 and February *** breast was taken as a single unit for a total of 5,544 ***:There were 2,334 patients in primary augmentation mammoplasty,258 in secondary augmentation mammoplasty and 180 in simultaneous mastopexy with augmentation *** were three autoinflation of breasts due to late seromas identified in the *** patients presented at least six months following augmentation mammoplasty and all had textured implants place in muscle splitting submuscular *** was no late seroma noted in secondary augmentation mammoplasty or simultaneous mastopexy with augmentation *** patients were treated conservatively without a ***:Late autoinflation of the breast due to seroma is an uncommon clinical complication and can be treated conservatively in the first instance.

关键词： anaplastic large cell lymphoma autoinflation of the breast haematoma seroma of breast anaplastic large cell lymphoma