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Camrelizumab-induced anaphylactic shock in an esophageal squamous cell carcinoma patient:A case report and review of literature

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World Journal of Clinical Cases 2022年第18期10卷 6198-6204页

作者： Kai Liu Jian-Feng Bao Tao Wang Hao Yang Bao-Ping Xu Department of Radiotherapy Traditional Chinese Hospital of Lu’an affiliated to Anhui University of Traditional Chinese MedicineLu’an 237000Anhui ProvinceChina Department of Immuno-logy Xixi Hospital of Hangzhou affiliated to Zhejiang University of Traditional Chinese MedicineHangzhou 310023Zhejiang ProvinceChina Department of Urology Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese MedicineZhongshan 528401Guangdong ProvinceChina Department of Critical Care Medicine Traditional Chinese Hospital of Lu’an affiliated to Anhui University of Traditional Chinese MedicineLu’an 237000Anhui ProvinceChina

BACKGROUND Camrelizumab(SHR-1210),an immune checkpoint inhibitor,is clinically used as a therapeutic option for various types of ***,reports of adverse reactions associated with camrelizumab are gradually *** shock due to camrelizumab has not been reported previously,until *** report here,for the first time,a case of anaphylactic shock associated with camrelizumab in a patient with esophageal squamous cell *** SUMMARY An 84-year-old male esophageal cancer patient received radiotherapy and chemotherapy 11 years *** was diagnosed with advanced esophageal squamous cell carcinoma with liver metastasis(Tx N1 M1)and received the first immunotherapy(camrelizumab 200 mg/each time,once every 3 wk)dose in December 2020,with no adverse *** weeks later,a generalized rash was noted on the chest and upper limbs;palpitations and breathing difficulties with a sense of dying occurred 10 min after the patient had been administered with the second camrelizumab *** monitoring revealed a 70 beats/min pulse rate,69/24 mm Hg(1 mm Hg=0.133 k Pa)blood pressure,28 breaths/min respiratory rate,and 86%pulse oximetry in room *** patient was diagnosed with anaphylactic shock and was managed with intravenous fluid,adrenaline,dexamethasone sodium phosphate,calcium glucosate,and *** 2 h after treatment,the patient’s anaphylactic shock symptoms had been completely *** Due to the widespread use of camrelizumab,attention should be paid to anti-programmed cell death 1 antibody therapy-associated hypersensitivity or anaphylactic shock.

关键词： Camrelizumab anaphylactic shock Anti-programmed cell death one antibodies Immunotherapy Case report

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Atezolizumab-induced anaphylactic shock in a patient with hepatocellular carcinoma undergoing immunotherapy:A case report

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World Journal of Clinical Cases 2021年第16期9卷 4110-4115页

作者： Li-Fang Bian Chao Zheng Xiao-Lan Shi Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina

BACKGROUND Atezolizumab is a programmed death ligand 1(PD-L1)inhibitor,and its combination with bevacizumab has been proven an effective immunotherapy for unresectable hepatocellular carcinoma(HCC).Treatment with immune checkpoint inhibitors(ICIs)can lead to hypersensitivity reactions;however,anaphylactic shock is *** present a case of life-threatening anaphylactic shock during atezolizumab infusion and performed a relevant literature *** SUMMARY A 75-year-old man was diagnosed with HCC recurrence after *** was administered immunotherapy with atezolizumab plus bevacizumab after an allergy to a programmed death-1(PD-1)*** patient showed a sudden onset of dizziness,numbness,and lack of consciousness with severe hypotension during atezolizumab *** treatment was stopped *** patient’s symptoms resolved after 5 mg dexamethasone was *** of repeated hypersensitivity reactions to ICIs,treatment was changed to oral targeted regorafenib *** Further research is necessary for elucidating the hypersensitivity mechanisms and establishing standardized skin test and desensitization protocols associated with PD-1 and PD-L1 to ensure effective treatment with ICIs.

关键词： Atezolizumab Immune checkpoint inhibitors anaphylactic shock Hypersensitivity reaction Infusion reaction Hepatocellular carcinoma Case report

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Identification and characterization of the causative triatomine bugs of anaphylactic shock in Zhanjiang,China

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Infectious Diseases of Poverty 2018年第1期7卷 1325-1333页

作者： Ya-Lan Huang Da-Na Huang Wei-Hua Wu Fan Yang Xiao-Min Zhang Miao Wang Yi-Jun Tang Qian Zhang Li-Fei Peng Ren-Li Zhang Shenzhen Center for Disease Control and Prevention Shenzhen 518055China Department of Parasitology Guangdong Medical UniversityZhanjiang 524005China

Background:Two health concerns primarily related to triatomine bugs are transmission of Trypanosoma cruzi through infective feces,and allergic reactions induced by triatomine *** the Southwestern United States,reduviid bugs bites commonly cause insect *** South China,four cases of anaphylactic shock have been reported after this bite *** further classify the species of these bugs and confirm the sensitization of the triatomine saliva,we caught triatomine bugs from the region where the bites occurred and performed phylogenetic and immunohistochemical(IHC)***:Triatomine bugs were collected in Donghai Island of Zhanjiang City in South *** genomic DNA was extracted from three legs of the *** fragments of mitochondrial 16S rRNA,cytochrome c oxidase subunit I(COI)gene and nuclear ribosomal 18S and 28S rRNA genes were obtained by PCR and sequenced.A phylogenetic tree was constructed based on the sequence of 16S rRNA gene using a maximum likelihood method with MEGA 7.0 *** specific fragments and vertebrate COI genes were amplified from the fecal DNA to detect the infection of trypanosomes and analyze the blood feeding patterns,***-embedded sections were then prepared from adult triatomines and sent for IHC ***:We collected two adult triatomine bugs in Donghai *** and molecular analyses indicated that the triatomines were Triatoma *** fragments of *** or other trypanosomes were detected from the fecal *** gene segments of Homo sapiens and Mus musculus were successfully *** allergens which induced specific IgE antibodies in human serum were localized in the triatomine saliva by IHC ***:The two triatomine bugs from Donghai Island were *** had bitten humans and *** saliva should contain the allergens related to the allergic symptoms and even anaphylactic shock of exposed *** consi

关键词： Triatoma rubrofasciata Chagas disease Trypanosoma cruzi anaphylactic shock

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Successful prolonged cardiopulmonary resuscitation after intraoperative cardiac arrest due to povidone-iodine allergy: A case report

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World Journal of Clinical Cases 2021年第33期9卷 10362-10368页

作者： Bing-Bing Xiang Yu-Ting Yao Shu-Lan Jiao Department of Anesthesiology Chengdu Fifth People's HospitalChengdu 611130Sichuan ProvinceChina Department of Anesthesiology The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400000China Department of Anesthesiology The Second Affiliated Hospital of Kunming Medical UniversityKunming 650101Yunnan ProvinceChina

BACKGROUND Iodophor(povidone-iodine)is widely used clinically because of its broadspectrum antibacterial *** extremely rare,it may cause anaphylactic shock,which itself carries the life-threatening risk of cardiac *** SUMMARY We present a case in which a patient with postoperative infection went into anaphylactic shock and cardiac arrest caused by povidone-iodine during secondary *** patient was successfully resuscitated by 2 h of cardiopulmonary *** This is the first known case of cardiac arrest caused by povidone-iodine allergy.

关键词： Povidone-iodine Allergy anaphylactic shock Cardiac arrest Cardiopulmonary resuscitation Case report

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Ruptured hydatid cyst in a patient with shock

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Hepatobiliary & Pancreatic Diseases International 2009年第6期8卷 638-639页

作者： Diego Castanares-Zapatero Pierre Franois Laterre Cliniques Universitaires Saint Luc Université Catholique de Louvain(UCL)Department of Critical Care MedicineAvenue Hippocrate

Echinococcosis is a severe helminthic zoonosis largely caused by Echinococcus granulosus and frequently encountered in endemic *** liver and lung are the most frequently involved *** rupture into the peritoneal cavity represents a rare but serious ***,we describe an acute occurrence of anaphylactic shock due to a spontaneous rupture of hydatid cyst in a 21-year-old Turkish patient unwittingly infected by *** surgery of the perforated cyst in combination with cleaning of the abdominal cavity was *** patient rapidly improved and no relapse occurred during a follow-up of 8 *** is a serious complication of hydatid cyst rupture and needs to be promptly *** main objective of our report is to underscore this life-threatening complication that should be considered when anaphylactic shock of unknown origin occurs,even in non-endemic ***,we emphasize the need for a radical surgical approach to avoid widespread dissemination.

关键词： ruptured hydatid liver cyst anaphylactic shock albendazole

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