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Exploring the efficacy of natural products in alleviating Alzheimer’s disease

Neural Regeneration Research 2019年第8期14卷 1321-1329页

作者： Prajakta Deshpande Neha Gogia Amit Singh Department of Biology University of Dayton Dayton OH USA Premedical Program University of Dayton Dayton OH USA Center for Tissue Regeneration and Engineering at Dayton (TREND) University of Dayton Dayton OH USA The Integrative Science and Engineering Center University of Dayton Dayton OH USA Center for Genomic Advocacy (TCGA) Indiana State University Terre Haute IN USA

Alzheimer’s disease(hereafter AD) is a progressive neurodegenerative disorder that affects the central nervous system. There are multiple factors that cause AD, viz., accumulation of extracellular amyloid-beta 42 plaques, intracellular hyper-phosphorylated Tau tangles, generation of reactive oxygen species due to mitochondrial dysfunction and genetic mutations. The plaques and tau tangles trigger aberrant signaling, which eventually cause cell death of the neurons. As a result, there is shrinkage of brain, cognitive defects, behavioral and psychological problems. To date, there is no direct cure for AD. Thus, scientists have been testing various strategies like screening for the small inhibitor molecule library or natural products that may block or prevent onset of AD. Historically, natural products have been used in many cultures for the treatment of various diseases. The research on natural products have gained importance as the active compounds extracted from them have medicinal values with reduced side effects, and they are bioavailable. The natural products may target the proteins or members of signaling pathways that get altered in specific diseases. Many natural products are being tested in various animal model systems for their role as a potential therapeutic target for AD, and to address questions about how these natural products can rescue AD or other neurodegenerative disorders. Some of these products are in clinical trials and results are promising because of their neuroprotective, anti-inflammatory, antioxidant, anti-amyloidogenic, anticholinesterase activities and easy availability. This review summarizes the use of animal model systems to identify natural products, which may serve as potential therapeutic targets for AD.

关键词： Alzheimer’s disease amyloid-beta 42 natural products Lunasin neuroprotective anti-inflammation antioxidant Drosophila cell death neurodegeneration

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