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Enzyme-digested Colla Corii Asini(E’jiao) prevents hydrogen peroxide-induced cell death and accelerates amyloid beta clearance in neuronal-like PC12 cells

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Neural Regeneration Research 2020年第12期15卷 2270-2277页

作者： Li Xiao Feng Liao Ryoji Ide Tetsuro Horie Yumei Fan Chikako Saiki Nobuhiko Miwa Department of Pharmacology The Nippon Dental UniversitySchool of Life Dentistry at TokyoTokyoJapan National Engineering Research Center for Gelatin-based Traditional Chinese Medicine Dong-E-E-Jiao Co.Ltd.LiaochengShandong ProvinceChina Department of Physiology The Nippon Dental UniversitySchool of Life Dentistry at TokyoTokyoJapan Research Center The Nippon Dental UniversitySchool of Life Dentistry at TokyoTokyoJapan Department of Life Sciences Prefectural University of HiroshimaHiroshimaJapan

As an aging-associated degenerative disease,Alzheimer’s disease is characterized by the deposition of amyloid beta(Aβ),oxidative stress,inflammation,dysfunction and loss of cholinergic *** Corii Asini(CCA)is a traditional Chinese medicine which has been used for feebleness-related diseases and *** might delay aging-induced degenerative changes in *** the present study,we evaluated antioxidant activity,cytoprotective effects,and Aβremovability of enzyme-digested Colla Corii Asini(CCAD).Oxygen radical absorbance capacity(ORAC)activity assay showed that,as compared to gelatins from the skin of porcine,bovine and cold water fish,CCA exhibited the highest ORAC *** ORAC activity of CCA and CCAD was increased gradually by the length of time in *** analysis by scanning electron microscopy showed that among CCA manufactured in 2008,2013,2017 and gelatin from cold water fish skin,CCA manufactured in 2008 presented the smoothest surface *** further tested the protective effects of CCAD(manufactured in 2008)and enzyme-digested gelatin from cold water fish skin(FGD)on hydrogen peroxide(H2O2)-induced cell death in nerve growth factor-differentiated neuronal-like PC12 *** blue assay showed that both FGD and CCAD at 0.5 mg/m L increased cell viability in H2O2-treated neuronal-like PC12 *** protection of CCAD was significantly superior to that of ***(Ach E)assay showed that both FGD and CCAD inhibited Ach E activity in nerve growth factor-differentiated neuronal-like PC12 cells to 89.1%and 74.5%of that in non-treated cells,*** data suggest that CCAD might be able to increase the neurotransmitter *** CCAD inhibited Ach E activity in neuronal-like PC12 cells,CCAD prevented H2O2-induced abnormal deterioration of Ach *** and neprilysin activity assay results indicated that CCAD reduced amyloid beta accumulation and increased neprilysin activity in Aβ1–

关键词： acetylcholinesterase activity Alzheimer’s disease amyloid beta clearance antioxidant Colla Corii Asini collagen neuroprotection PC12 cells

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Alleviating the unwanted effects of oxidative stress on Aβclearance:a review of related concepts and strategies for the development of computational modelling

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Translational Neurodegeneration 2023年第1期12卷 702-721页

作者： Sarawoot Somin Don Kulasiri Sandhya Samarasinghe Centre for Advanced Computational Solutions(C-fACS) Lincoln UniversityChristchurch 7647New Zealand Department of Wine Food and Molecular BiosciencesLincoln UniversityChristchurch 7647New Zealand

Treatment for Alzheimer’s disease(AD)can be more effective in the early *** we do not completely understand the aetiology of the early stages of AD,potential pathological factors(amyloid beta[Aβ]and tau)and other co-factors have been identified as causes of AD,which may indicate some of the mechanism at work in the early stages of ***,one of the primary techniques used to help delay or prevent AD in the early stages involves alleviating the unwanted effects of oxidative stress on Aβclearance.4-Hydroxynonenal(HNE),a product of lipid peroxidation caused by oxidative stress,plays a key role in the adduction of the degrading *** HNE employs a mechanism which decreases catalytic *** process ultimately impairs Aβ*** degradation of HNE-modified proteins helps to alleviate the unwanted effects of oxidative *** a clear understanding of the mechanisms associated with the degradation of the HNE-modified proteins is essential for the development of strategies and for alleviating the unwanted effects of oxidative *** strategies which could be employed to decrease the effects of oxidative stress include enhancing antioxidant activity,as well as the use of nanozymes and/or specific *** area which shows promise in reducing oxidative stress is protein ***,more research is needed to improve the effectiveness and accuracy of this *** paper discusses the interplay of potential pathological factors and *** particular,it focuses on the effect of oxidative stress on the expression of the Aβ-degrading proteases through adduction of the degrading proteases caused by *** paper also elucidates other strategies that can be used to alleviate the unwanted effects of oxidative stress on Aβ*** improve the effectiveness and accuracy of protein design,we explain the application of quantum mechanical/molecular mechanical approach.

关键词： Alzheimer’s disease Oxidative stress amyloid beta clearance Protein design

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