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aminooxyacetic acid improves learning and memory in a rat model of chronic alcoholism

Neural Regeneration Research 2018年第9期13卷 1568-1574页

作者： Ai-Lin Du Hao-Zhi Qin Hong-Bo Jiang Peng-Yan Fu Ke Lou Yu-Ming Xu Department of Neurology First Affiliated Hospital of Zhengzhou University Zhengzhou Henan Province China Department of Physiology and Neurobiology Xinxiang Medical University Henan Provincial Key Laboratory of Brain Research Second Affiliated Hospital of Xinxiang Medical University Xinxiang Henan Province China Third Affiliated Hospital of Xinxiang Medical University Xinxiang Henan Province China

Chronic alcoholism seriously damages the central nervous system and leads to impaired learning and *** damage in chronic alcoholism is strongly associated with elevated levels of hydrogen sulfide（H2S） and calcium ion *** acid is a cystathionine-β-synthase activity inhibitor that can reduce H2S formation in the *** study sought to observe the effect of aminooxyacetic acid on learning and memory in a chronic alcoholism rat *** were randomly divided into three *** in the control group were given pure water for 28 *** in the model group were given 6% alcohol for 28 days to establish an alcoholism rat *** in the aminooxyacetic acid remedy group were also given 6% alcohol for 28 days and were also intraperitoneally injected daily with aminooxyacetic acid（5 mg/kg） from day 15 to day *** and memory was tested using the Morris water maze *** ultrastructure of mitochondria in the hippocampus was observed by electron microscopy.H2S levels in the hippocampus were measured indirectly by spectrophotometry,and ATPase activity was measured using a commercial *** expression of myelin basic protein was determined by immunohistochemistry and western *** with the control group,latency and swimming distance were prolonged in the navigation test on days 2,3,and 4 in the model *** the spatial probe test on day 5,the number of platform crosses was reduced in the model *** cracks,swelling or deformation of mitochondria appeared in the hippocampus,the hippocampal H2S level was increased,the mitochondrial ATPase activity was decreased,and the expression of myelin basic protein in the hippocampus was down-regulated in the model group compared with the control *** the above indexes were ameliorated in the aminooxyacetic acid remedy group compared with the model *** findings indicate that aminooxyacetic acid can improve learning and memory in a chronic alcoholism rat model,w

关键词： nerve regeneration aminooxyacetic acid chronic alcoholism rat model hydrogen sulfide Ca2+ overload brain injury learning andmemory abilities Morris water maze myelin basic protein mitochondria ATP enzyme activity neural regeneration

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Neuroprotective mechanism of L-cysteine after subarachnoid hemorrhage

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Neural Regeneration Research 2020年第10期15卷 1920-1930页

作者： Ye Xiong Dan-Qing Xin Quan Hu Ling-Xiao Wang Jie Qiu Hong-Tao Yuan Xi-Li Chu De-Xiang Liu Gang Li Zhen Wang Department of Physiology School of Basic Medical SciencesShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Qilu Hospital of Shandong University and Brain Science Research InstituteShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Taian Central HospitalTaianShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesShandong UniversityJinanShandong ProvinceChina

Hydrogen sulfide,which can be generated in the central nervous system from the sulfhydryl-containing amino acid,L-cysteine,by cystathionine-β-synthase,may exert protective effects in experimental subarachnoid hemorrhage;however,the mechanism underlying this effect is *** study explored the mechanism using a subarachnoid hemorrhage rat model induced by an endovascular perforation *** were treated with an intraperitoneal injection of 100 mM L-cysteine(30μL)30 minutes after subarachnoid *** 48 hours after subarachnoid hemorrhage,hematoxylin-eosin staining was used to detect changes in prefrontal cortex cells.L-cysteine significantly reduced cell *** function was assessed using a modified Garcia *** water content was measured by the wet-dry method.L-cysteine significantly reduced neurological deficits and cerebral edema after subarachnoid *** was used to detect the number of activated *** transcription-polymerase chain reaction(RT-PCR)was used to detect the levels of interleukin 1β and CD86 mRNA in the prefrontal cortex.L-cysteine inhibited microglial activation in the prefrontal cortex and reduced the mRNA levels of interleukin 1βand ***-PCR and western blot analysis of the complement system showed that L-cysteine reduced expression of the complement factors,C1q,C3αand its receptor C3aR1,and the deposition of C1q in the prefrontal *** staining was applied to detect changes in reactive oxygen species,and immunohistochemistry was used to detect the number of NRF2-and HO-1-positive cells.L-cysteine reduced the level of reactive oxygen species in the prefrontal cortex and the number of NRF2-and HO-1-positive *** blot assays and immunohistochemistry were used to detect the protein levels of CHOP and GRP78 in the prefrontal cortex and the number of CHOP-and GRP78-positive cells.L-cysteine reduced CHOP and GRP78 levels and the number of CHOP-and GRP78-

关键词： aminooxyacetic acid central nervous system complement deposition cystathionine-β-synthase early brain injury endoplasmic reticulum stress hydrogen sulfide neuroinflammation oxidative stress subarachnoid hemorrhage

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