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Co-delivery of mRNA and SPIONs through amino-ester nanomaterials

Nano Research 2018年第10期11卷 5596-5603页

作者： Xiao Luo Weiyu Zhao Bin Li Xinfu Zhang Chengxiang Zhang Anna Bratas Binbin Deng David W. McComb Yizhou Dong Division of Pharmaceutics and Pharmaceutical Chemistry College of Pharmacy The Ohio State University Columbus Ohio 43210 USA Small Animal Imaging Core The Ohio State University Columbus Ohio 43210 USA Center for Electron Microscopy and Analysis Department of Materials Science and Engineering The Ohio State University Columbus Ohio 43210 USA Department of Biomedical Engineering The Ohio State University Columbus Ohio 43210 USA The Center for Clinical and Translational Science The Ohio State University Columbus Ohio 43210 USA The Comprehensive Cancer Center The Ohio State University Columbus Ohio 43210 USA Dorothy M. Davis Heart & Lung Research Institute The Ohio State University Columbus Ohio 43210 USA Department of Radiation Oncology The Ohio State University Columbus Ohio 43210 USA

Nanoparticles have been widely explored for combined therapeutic and diagnostic applications. For example, lipid-based nanoparticles have been used to encapsulate multiple types of agents and achieve multi-functions. Herein, we enabled a co-delivery of mRNA molecules and superparamagnetic iron oxide nanoparticles （SPIONs） by using an amino-ester lipid-like nanomaterial. An orthogonal experimental design was used to identify the optimal formulation. The optimal formulation, MPA-Ab-8 LLNs, not only showed high encapsulation of both mRNA and SPIONs, but also increased the r2 relaxivity of SPIONs by more than 1.5-fold in vitro. MPA-Ab-8 LLNs effectively delivered mRNA and SPIONs into cells, and consequently induced high protein expression as well as strong MRI contrast. Consistent herewith, we observed both mRNA-mediated protein expression and an evident negative contrast enhancement of MRI signal in mice. In conclusion, amino-ester nanomaterials demonstrate great potential as delivery vehicles for theranostic applications.

关键词： amino-ester nanomaterials lipid-like nanoparticles(LLNs) dual-functional superparamagnetic iron oxide nanoparticles(SPIONs) mRNA delivery magnetic resonance imaging (MRI)

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