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Incidence of ocular manifestations in patients with graft versus host disease after allogeneic stem cell transplant in Riyadh, Saudi Arabia

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International Journal of Ophthalmology(English edition) 2022年第7期15卷 1149-1156页

作者： Tariq Aldebasi Rabia Bashir Shiji Gangadharan Naila AShaheen Basil Alhussain Tariq Almudhaiyan Bader Alahmari Department of Ophthalmology King Abdulaziz Medical CityNational Guard Health AffairsRiyadh 11426Saudi Arabia King Abdullah International Medical Research Center(KAIMRC) Riyadh 11426Saudi Arabia King Saud bin Abdulaziz University for Health Sciences Riyadh 11426Saudi Arabia Divisions of Adult Hematology and SCT King Abdulaziz Medical CityNational Guard Health AffairsRiyadh 11426Saudi Arabia

AIM: To evaluate the incidence and severity of ocular graft versus host disease(o GVHD) in patients who underwent allogeneic stem cell transplant(SCT) in King Abdul-Aziz Medical City, Saudi ***: This is a retrospective cohort study conducted in King Abdul Aziz Medical City on patients who underwent allogeneic hematopoietic cell transplant(allo-HCT) from 2010 to 2017. The ocular examination findings including visual acuity, meibomian gland dysfunction, corneal and conjunctival staining with severity, corneal scarring, tear film meniscus and breakup time, anterior and posterior segment examination findings, intraocular pressure, treatment given, punctual plugs used or not, and follow up response were ***: The five years cumulative incidence of o GVHD among post-transplant patients was 56.98%(95%CI 38.6%-71.7%). The potential risk factors assessed for developing ocular manifestation were age, gender, donor’s age, donor gender mismatch CD3 and CD34 infusion, while none of the correlates were identified as statistically significant risk factors of developing ocular manifestation. However, the incidence was statistically significantly different betweenpatients diagnosed with acute myelocytic leukemia and acute lymphocytic leukemia(P=0.038). The mean latent period to develop ocular symptoms was 20.5 mo. All patients had variable degree of dry eyes. None of the patients developed any posterior segment ***: The incidence of o GVHD is low in King Abdul-Aziz Medical City. This can be attributed to the preconditioning and immunosuppressive regime.

关键词： graft versus host disease allogenic stem cell transplant dry eye

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