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Patterns of liver profile disturbance in patients with COVID-19

World Journal of Clinical Cases 2022年第7期10卷 2063-2071页

作者： Hend Ibrahim Shousha Ahmed Ramadan Rania Lithy Mohamed El-Kassas Department of Endemic Medicine Faculty of MedicineCairo UniversityCairo 12556Egypt Department of Endemic Medicine Faculty of MedicineHelwan UniversityCairo 11795Egypt

Fever and cough are the most common clinical symptoms of coronavirus disease 2019(COVID-19),but complications(such as pneumonia,respiratory distress syndrome,and multiorgan failure)can occur in people with additional ***-19 may be a new cause of liver disease,as liver profile disturbance is one of the most common findings among *** molecular mechanism underlying this phenomenon,however,is still *** this paper,we review the most current research on the patterns of change in liver profile among patients with COVID-19,the possible explanation for these findings,and the relation to pre-existing liver disease in these patients.

关键词： Liver functions COVID-19 Liver profile alanine transaminase aspartate transaminase Bilirubin

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Biochemical Changes in Hybrid Catfish (Heterobranchus bidorsalis,♂ x Clarias gariepinus,♀) Treated with Nuracron

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应用与环境生物学报 2010年第3期16卷 353-357页

作者： GABRIEL Ugwemorubong Ujagwung OBOMANU Faithwin Gamalie EDORI Onisogen Simon Department of Fisheries and Aquatic Environment Rivers State University of Science & Technology P.M.B 5080 Port Harcourt 5000001 Nigeria Department of Chemistry Rivers State University of Science & Technology P.M.B 5080 Port Harcourt 5000001 Nigeria Department of Chemistry Rivers State University of Education P.M.B. 5047 Rumuolameni Port Harcourt. 5000001 Nigeria

The effects of sublethal levels of nuracron,dimethylphosphate-3-hydroxy-N-methyl-cis-crotonamide(0,0.625× 10-6,1.25×10-6,2.5×10-6,5.0×10-6 and 10.0×10-6) on biochemical changes(aspartate transaminase,AST,E.C.2.***.1.1;alanine transaminase,ALT;2.***.2.2;alkaline phosphatase,ALP,EC 3.***.3.1) in the organs(kidney,liver,gill) and muscle tissues of hybrid catfi sh Heterobranchus bidorsalis,♂× Clarias gariepinus,♀ [mean weight,(277.76±53.11) g SD;mean total length,(35.69±2.80) cm,SD] were studied after a 23 d exposure in a renewal bioassay under laboratory ***,nuracron inhibited AST,ALT and ALP activities in all the exposure concentrations,with ALT activity being mostly *** most elicited enzyme was ALP in the kidney [(4 052.67±1610.45) IU/L],followed by AST in the muscle [(908.44±218.34) IU/L] and ALT in the liver [(160.29±73.68) IU/L].The ALP activity was 30.24 and 6.53 times greater than that of ALT and *** highest inhibition for AST(43.65%),ALT(47.88%) and ALP(57.98%) occurred at 10×10-6,0.625×10-6 and 2.5×10-6,*** activities of the enzymes in all the organs did not show any direct relationship with the exposure concentrations of the *** activity in the muscle generally suffered the most compared with the other *** activities of enzymes in the liver were generally inhibited,with elevation at 5.0×10-6 for all the *** lower concentrations of nuracron(0.625 ×10-6～2.5×10-6) caused elevation in the activities of ALP,but the reverse was the case with the higher concentrations;these of AST and ALT were *** relative activities of the various enzymes in the organs showed that the order for AST was liver>muscle>kidney>gill;that for ALT:liver>kidney,muscle>gill and that for ALP:kidney>gill>liver and ***,for AST and ALT the activities in the organs of the exposed fi sh peaked at 5.0×10-6 *** alteration in the activities of the enzymes indicated that the extract interfered with the Kreb's c

关键词： aspartate transaminase alanine transaminase alkaline phosphatase hybrid catfi sh nuracron

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HBV genotype characterization and distribution in patients with HBV-related liver diseases in Zhejiang Province, P. R. China: possible association of co-infection with disease prevalence and severity

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Hepatobiliary & Pancreatic Diseases International 2005年第4期4卷 535-543页

作者： Edward Zumbika Institute of Infectious Diseases the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003People's Republic of China

BACKGROUND: There are 8 well-documented genotypes of hepatitis B virus (HBV) at this time point. Genotyping can be accomplished based on a partial sequence of hepatitis B virus (HBV) genome such as the pre-S or S gene. Several methods have been developed and used for HBV genotyping including direct sequencing, restriction fragment length polymorphism, line probe assay and enzyme-linked immunoassay. Recently, a novel, rapid and cost-effective genotyping method based on PCR amplification assay using type-specific primers that can identify all six major genotypes has been developed. This study was undertaken to characterise HBV genotypes and investigate the association between the prevalence of different genotypes and the severity of HBV-induced liver diseases. METHODS: Serum samples from carriers of HBV and patients with HBV-related liver diseases from Zhejiang Province were screened for viral serological markers using commercially available radioimmunoassay (RIA) and enzyme linked immunosorbent assay (ELISA) kits. Serum HBV DNA load was determined by real-time detection PCR. A type-specific primer based the nested-PCR method was employed in the HBV genotyping. The genotype results obtained were confirmed by direct sequencing of nested PCR amplicons of the pre-S region. Ten samples of each genotype (B and C) were sequenced. RESULTS: The survey on a cohort of 125 HBV carriers in and around Hangzhou City, Zhejiang Province showed the existence of HBV genotypes A (0.8%), B (48%), C (40.8%), D (0.8%), mixed B and C (9.6%) and an absence of E and F genotypes. Distribution of HBV genotypes in patients with liver diseases revealed a statistically insignificant higher prevalence of genotype B in mild chronic hepatitis (CH). Among the three genotypes B, C and mixed B/C infections 11 (73.3%), 3 (20%) and 1 (6.7%), (P< 0.05), respectively in subjects with moderate CH, genotype B was significantly predominant. The infection patterns for genotypes B, C and B/C mixed in (i) liver c

关键词： hepatitis B virus chronic hepatitis B liver cirrhosis hepatocellular carcinoma hepatitis B e antigen hepatitis B virus DNA load viremia hepatitis B genotypes liver function tests alanine transaminase aspartate transaminase real-time detection PCR

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Monitoring the level of serum paraoxonase 1 activity in liver transplantation patients

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Hepatobiliary & Pancreatic Diseases International 2005年第2期4卷 178-181页

作者： Gen-Yun Xu, Guo-Cai Lv, Yu Chen, Yong-Chuan Hua, Shen-Mei Zhu and Yi-Da Yang Hangzhou, China Clinical Laboratory, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China Clinical Laboratory First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China. genyunxu@***

BACKGROUND: Paraoxonase 1(PON1) is an ester hydro- lase in serum and in the liver. Studies have suggested that PON1 measurement to the current battery of tests may im- prove the evaluation of chronic liver diseases. The aim of this study was to investigate the clinical significance of mo- nitoring the level of serum PON1 activity in liver transplan- tation patients. METHODS: A series of biochemical indexes were moni- tored in preoperative, operative and postoperative serum samples of 17 liver-transplanted patients. The change of se- rum PON1 level and its relations with other biochemical in- dexes were analyzed. RESULTS: PON1 was distributed normally in the healthy population and its reference value ranged from 45.5 to 265.8 U/mL. The PON1 level of all patients was lower than that of control group significantly (P<0.001); the level be- gan to elevate continuously 5 minutes after opening of the portal vein and was higher than that 90 minutes after open- ing of the portal vein ( P <0.05). Two days after operation it was still higher than the normal. The levels of serum ALT and AST elevated more significantly after opening of the portal vein than before operation and they were higher than the normal values till 2 days after the operation. CONCLUSIONS: The level of PON1 in serum may be taken as one of the effective indexes to assess whether the implant is alive and to monitor liver function of the patient together with other tests.

关键词： paraoxonase 1 liver transplantation alanine transaminase aspartate transaminase γ-glutamyltransferase cholinesterase

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Interim results from ongoing PhaseⅢ placebo-controlled,randomized trial of hepcortespenlisimut-L for advanced hepatocellular carcinoma indication

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Hepatoma Research 2020年第1期6卷 11-18页

作者： Aldar S.Bourinbaiar Jigjidsuren Chinburen Purev Batchuluun Chogsom Munkhzaya DandiiOyungerel Dorjiin Dandii Galyna A.Kutsyna Hulan Tsogkhuu Marina G.Tarakanovskaya Alan A.Reid Vika Borisova Allen I.Bain Vichai Jirathitikal Immunitor Inc. VancouverBCV6K 2G8Canada National Cancer Center Ulaanbaatar 14000Mongolia National Center for Public Health Ulaanbaatar 13000Mongolia National Cancer Institute National Institutes of HealthBethesdaMD 20892USA Ekomed LLC Ulaanbaatar 13381Mongolia Immunitor China Ltd. ChaoyangBeijing 100027China

Aim:We aimed to further investigate the role of hepcortespenlisimut-L(Hepko-V5 or V5),a new oral immunotherapy developed by us,for hepatocellular carcinoma(HCC)***:The interim data from ongoing PhaseⅢplacebo-controlled,randomized trial were evaluated on the initial group of patients in advanced stage of HCC with emphasis on liver function and tumor marker alpha-fetoprotein ***,an in vitro study was undertaken to elucidate the mechanism of action of V5 by measuring with flow cytometry the expression of cytokines such as IL-2,INF-γ,and TNF-αand cell activation markers CD69 and Ki67 on CD4-and CD8-positive lymphocytes isolated from peripheral blood of healthy ***:As early as one month after treatment initiation,there was a clear improvement in alanine transaminase,aspartate transaminase,alkaline phosphatase,and bilirubin levels among HCC patients who received daily dose of V5,but not in the placebo ***,alpha-fetoprotein(AFP)levels among V5 recipients decreased,while in the ;placebo group they *** results are in line with in vitro observations indicating immune activation,as evidenced by many-fold enhancement of CD69,Ki67,and INF-γexpression and at the same time marked anti-inflammatory effect resulting in 10-fold decrease in TNF-αoutput and lack of influence on IL-2 ***:Hepcortespenlisimut-L,a tableted oral formulation derived from heat-inactivated pooled blood of patients with HCC and viral hepatitis shows beneficial clinical effect,as demonstrated by improvement in liver function and reduction of tumor marker AFP *** correlate with in vitro observations showing potent activation of the immune response and pronounced oral tolerance effect.

关键词： Hepatocellular carcinoma alpha-fetoprotein alanine transaminase aspartate transaminase IL-2 INF-γ TNF-α CD69 Ki67 CD4 CD8 T lymphocytes

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