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Correlation Analysis Between BDNF and Postoperative Cognitive Dysfunction in aged rats

Journal of Clinical and Nursing Research 2022年第4期6卷 108-113页

作者： Yuming Zhang Hui Wang Fang Chen Jun Wang Ning Bai Department of Anesthesiology Shaanxi Provincial People’s HospitalXi’an 710068Shaanxi ProvinceChina Department of Anesthesiology Shaanxi Provincial Cancer HospitalXi'an 710061Shaanxi ProvinceChina

Objective:To investigate the relationship between BDNF and postoperative cognitive dysfunction among aged ***:36 SPF healthy aged male SD rats were randomly assigned to a control group and a model group,respectively,with 18 rats in each *** exploration was performed on the rats in the model group after anesthesia,while the rats in the control group were not operated on after *** escape latency and swimming distance of the two groups were analyzed on a day prior to surgery as well as on the first day,third day,and seventh day following surgery;the expression levels of BDNF protein in the hippocampus of rats in the two groups were compared on the first day,third day,and seventh day following surgery;the correlation between BDNF and escape latency and swimming distance was ***:The escape latency and swimming distance of the rats in the control group on a day prior to surgery,the first day,third day,and seventh day following surgery did not differ significantly(p>0.05),but those in the model group had significant behavioral difference(prats in both groups showed no significant behavioral difference in escape latency and swimming distance(p>0.05),but on the first day,third day,and seventh day following surgery,the escape latency and swimming distance of the rats in the model group were significantly longer than those in the control group(prats on the first day,third day,and seventh day following surgery,but there was significant difference in the model *** the first day,third day,and seventh day following surgery,the BDNF protein expression level in the rats’hippocampus of the control group was significantly higher than that of the model group(p<0.05).The data from Pearson correlation analysis confirmed that BDNF protein expression is negatively correlated with escape

关键词： BDNF aged rats Postoperative cognitive dysfunction Escape latency Swimming distance

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Changes in intracellular calcium in brain cells of aged rats

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Neural Regeneration Research 2008年第9期3卷 1026-1029页

作者： Yu Li Yunpeng Cao Department of Neurology The First Hospital of China Medical University Shenyang 110001 Liaoning Province China

BACKGROUND： Studies have shown that voltage-dependent calcium influx, and enhancement of certain calcium-dependent processes in neurons, is related to aging. OBJECTIVE： To observe changes in intracellular calcium （[Ca^2＋]i） in neurons of aged rats, and to compare with young rats. DESIGN, TIME AND SETTING： A randomized control experiment of neurophysiology was performed at the Central Laboratory of School of Pharmaceutical Science, China Medical University from June to August 2004. MATERIALS： Ten male, healthy, Wistar rats, 19 months old, were selected for the aged group. Ten male, 3-month-old, Wistar rats were selected for the young control group. Fura-2/AM was provided by the Institute of Pharmaceutical Research of Chinese Academy of Medical Sciences, and the F-2000 fluorospectrophotometer was a product of Hitachi, Japan. METHODS： Fluorescence Fura-2 spectrophotometer was used to measure [Ca^2＋]i in acutely dissociated brain cells of aged and young rats. The concentration of extracellular potassium was controlled by adding different volumes of chloridated potassium solution of high concentration. MAIN OUTCOME MEASURES： [Ca^2＋]i in neurons of young and aged rats in the presence of I mmol/L extracellular calcium concentration and 0 mmol/L （resting state）, 5, 10, 20, and 40 mmol/L extracellular potassium. Absolute increase of [Ca^2＋]i in neurons of young and aged rats when extracellular potassium was 5, 10, 20, 40 mmol/L. RESULTS： In the presence of 1 mmol/L extracellular Ca〉 and 0 mmol/L （resting state）, 5, 10, 20, and 40 mmol/L extracellular potassium, [Ca^2＋]i in the neurons of aged rats was significantly less than that in young rats （P 〈 0.05）. However, there was no significant difference in absolute [Ca^2＋]i increase induced by different concentrations of KCI between the aged and the young rats （P 〉 0.05）. CONCLUSION： The overload of [Ca^2＋]i in neurons of aged rats is greater than that of young rats under the same circumstances.

关键词： aged rats neuron intracellular calcium

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Eleutheroside B or E enhances learning and memory in experimentally aged rats

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Neural Regeneration Research 2013年第12期8卷 1103-1112页

作者： Debin Huang Zehua Hu Zhaofen Yu Department of Pharmacology Hubei Institute for Nationalities

Eleutheroside B or E, the main component of Acanthopanax, can relieve fatigue, enhance memory, and improve human cognition. Numerous studies have confirmed that high doses of acetylcholine significantly attenuate clinical symptoms and delay the progression of Alzheimer＇s disease. The present study replicated a rat model of aging induced by injecting quinolinic acid into the hippocampal CA1 region. These rats were intraperitoneally injected with low, medium and high doses of eleutheroside B or E （50, 100, 200 mg/kg）, and rats injected with Huperzine A or PBS were used as controls. At 4 weeks after administration, behavioral tests showed that the escape latencies and errors in searching for the platform in a Morris water maze were dose-dependently reduced in rats treated with medium and high-dose eleutheroside B or E. Hematoxylin-eosin staining showed that the number of surviving hippocampal neurons was greater and pathological injury was milder in three eleutheroside B or E groups compared with model group. Hippocampal homogenates showed enhanced cholinesterase activity, and dose-dependent increases in acetylcholine content and decreases in choline content following eleutheroside B or E treatment, similar to those seen in the Huperzine A group. These findings indicate that eleutheroside B or E improves learning and memory in aged rats. These effects of eleutheroside B or E may be mediated by activation of cholinesterase or enhanced reuse of choline to accelerate the synthesis of acetylcholine in hippocampal neurons.

关键词： neural regeneration traditional Chinese medicine eleutheroside B or E quinolinic acid aged rats Huperzine A learning and memory hippocampus acetylcholine cholinesterase choline mechanism grants-supported paper neuroregeneration

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Effects of Different Doses of BDNF on Postoperative Cognitive Function in aged rats Undergoing Abdominal Surgery

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Proceedings of Anticancer Research 2022年第4期6卷 65-70页

作者： Yuming Zhang Hui Wang Kai Lu Jun Wang Ning Bai Department of Anesthesiology Shaanxi Provincial People’s HospitalXi’an 710068Shaanxi ProvinceChina Department of Anesthesiology Shaanxi Provincial Cancer HospitalXi'an 710061Shaanxi ProvinceChina

Objective:To investigate the effects of different doses of BDNF on postoperative cognitive function in aged rats undergoing abdominal ***:72 aged healthy male SD rats of SPF grade were *** to the random number table method,the rats were randomly divided into the control group,model group,low dose BDNF injection group,and high dose BDNF injection group,with 18 rats in each *** model group,low dose group,and high dose group underwent abdominal surgery after anesthesia,and 5μL/time of BDNF was intranasally administered to the rats in the low dose and high dose groups 6 hours after abdominal surgery,of which the dose of the low dose group was 0.1 g/L,while that of the high dose group was 0.2 g/*** drug was administered alternately through both nostrils,with an interval of 2 minutes each time,for 5 *** control group did not undergo surgery after *** escape latency and swimming distance of the four groups of rats were compared before surgery,the first day,the third day,and the seventh day after surgery;similarly,the BDNF protein expression level in the hippocampus of the four groups of rats was compared on the first day,the third day,and the seventh day after ***:The escape latency and swimming distance of the control group were not statistically significant on the first day,the third day,and the seventh day after surgery,p>0.05;the escape latency and swimming distance of the model group,low dose group,and high dose group on the first day,the third day,and the seventh day after surgery were statistically significant,p0.05;on the first day,the third day,and the seventh day after surgery,the escape latency and swimming distance of the model group>low dose group>high dose group>control group,p<*** BDNF protein expression level in the hippocampus of the control group on the first day,the thir

关键词： BDNF Abdominal surgery aged rats Postoperative cognitive function

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Effect of Total Saponins of Ginseng Leaves on Immunity in aged rats

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Chinese Journal of Integrative Medicine 1999年第1期5卷 50-53页

作者：张克坚刘耕陶

Objective: To explore the effect of total saponins of Ginseng leaves(GS) on the functions ofneutrophil and lymphocyte in the aged rats of 20 months. Methods: Three groups of aged rats were injected intraperiton-eally with doses of 12. 5 mg/kg, 25 kg/mg and 50 mg/kg of GS once daily for 3 days, the declinedimmunity of spleen lymphocytes (proliferation of spleen lymphocyte, phagocytosis), superoxide anion and nitricoxide formation were studied and were compared with those of young rats (2 months). Results: The declinedimmunity of spleen lymphocytes were improved dose-dependently after GS injected. Conclusion: The results indicate that GS may enhance neutrophil and lymphocyte mediated non--specific and specific defense function inaged rats.

关键词： ginseng saponins aged rats neutrophils lymphocytes

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