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Neural Regeneration Research 2019年第9期14卷 1544-1555页

作者： Laia Farras-Permanyer Nuria Mancho-Fora Marc Montala-Flaquer David Bartres-Faz Lidia Vaque-Alcazar Maribel Pero-Cebollero Joan Guardia-Olmos Quantitative Psychology Section Faculty of PsychologyUniversity of BarcelonaBarcelonaSpain Department of Medicine Faculty of Medicine and Healthy SciencesUniversity of BarcelonaBarcelonaSpain Institute of Neuroscience UB Institute of Complex SystemsUniversity of BarcelonaBarcelonaSpain Institut d’Investigacions Biomediques August Pi i Sunyer BarcelonaSpain

age-related changes in the brain connectivity of healthy older adults have been widely studied in recent years,with some differences in the obtained *** of these studies showed decreases in general functional connectivity,but they also found increases in some particular regions and ***,these studies compared young individuals with older subjects,but few studies compared different age groups only in older *** purpose of this study is to analyze whole-brain functional connectivity in healthy older adult groups and its network characteristics through functional segregation.A total of 114 individuals,48 to 89 years old,were scanned using resting-state functional magnetic resonance imaging in a resting state paradigm and were divided into six different age groups(age groups and this was particularly pronounced between 75 and 79 years *** oldest group(≥80 years old)showed a slight increase in functional connectivity compared to the other *** occurred possibly because of compensatory mechanism in brain *** study provides information on the brain functional characteristics of every age group,with more specific information on the functional progressive decline,and supplies methodological tools to study functional connectivity *** for the study was obtained from the ethics committee of the Comision de Bioetica de la Universidad de Barcelona(approval ***2012-38257)on June 5,2012,and from the ethics committee of the Barcelona’s Hospital Clinic(approval No.2009-5306 and 2011-6604)on October 22,2009 and April 7,2011 respectively.

关键词： brain connectivity resting state default mode network aging healthy functional connectivity resting state network age groups

age-specific effectiveness of primary human papillomavirus screening versus cytology in a cervical cancer screening program: a nationwide cross-sectional study

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Cancer Communications 2022年第3期42卷 191-204页

作者： Heling Bao Lan Ma Yanxia Zhao Bo Song Jiangli Di Linhong Wang Yanqiu Gao Wenhui Ren Shi Wang Jiuling Wu Hai-Jun Wang Department of Maternal and Child Health School of Public HealthPeking UniversityBeijing 100191P.R.China National Center for Women and Children’s Health Chinese Center for Disease Control and PreventionBeijing 100081P.R.China National Center for Chronic and Non-communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 100050P.R.China

Background:Primary human papillomavirus(HPV)screening is recommended for the detection of cervical intraepithelial neoplasia(CIN)in the general pop-ulation;however,the triage for HPV-positive women remains a *** study aimed to evaluate the age-specific effectiveness of primary HPV screening versus primary cytology screening for identifying optimal strategies for women of different ***:The dataset of the prevalence round screening was derived from the National Cervical Cancer Screening Program in *** cervical screen-ing protocols included cytology only,HPV testing with cytology triage,and HPV testing with HPV-16/18 genotyping plus cytology *** primary outcomes were age-specific detection rate,colposcopy referral rate and positive predictive value(PPV)for CIN2+.Multivariate Poisson regression was used to evaluate the r*** 2 statisticwitharandom-effectmodelwasusedtotesttheheterogeneityinrelative effectiveness of HPV testing versus cytology between age ***:This study included 1,160,981 *** testing with HPV-16/18 genotyping plus cytology triage significantly increased the CIN2+detection by 36%(rate ratio[RR]:1.36,95%confidential interval[CI]1.21–1.54)for women aged 35-44 years and by 34%(RR:1.34,95%CI 1.20-1.51)for women aged 45-54 years compared with cytology *** testing with cytology triage had simi-lar CIN2+detection rate compared with cytology *** PPVs were substan-tially increased for both HPV testing *** women aged 55-64 years old,HPV testing with HPV-16/18 genotyping plus cytology triage increased the colposcopyreferralrateby19%(RR1.19,95%CI1.10-1.29)comparedwithcytology only,butdidnotincreasetheCIN2+detection(1.09,0.91–1.30).Theeffectiveness ***-age-group heterogeneity in the effectiveness was statistically significant for HPV testing with HPV-16/18 genotyping plus c

关键词： age groups cervical intraepithelial neoplasia cytology early detection of cancer human papil-lomavirus test mass screening triage uterine cervical neoplasms

Distribution of rare earth elements in agricultural soil and human body(scalp hair and urine) near smelting and mining areas of Hezhang, China

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Journal of Rare Earths 2016年第11期34卷 1156-1167页

作者：玛瑞亚季宏兵高阳丁淮剑李彩 Energy and Environmental Engineering School University of Science and Technology Beijing State Key Laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of Sciences

Rare earth elements （REEs） in recent decade are widely used and lead to the accumulation of REE in the environment and human body. The aim of this study was to evaluate the concentrations of REEs in soil and human body （scalp hair and urine） of peo-ple living in agricultural soil near smelting and mining areas in Hezhang County, China. The results showed that mean concentrations of determined REEs in agricultural soil from smelting areas were higher than background. However, concentration was slightly higher in soil in mining area. In addition, REEs concentrations of hair and urine in smelting areas were higher than those in mining areas.ΣREEs for soil in mining and smelting areas were 177.79 and 277.06 mg/kg, respectively.ΣREEs for hair in mining and smelting were 1.13 and 1.55 mg/kg, respectively, andΣREEs for urine in mining and smelting were 0.58 and 0.59 μg/L, respectively. Results showed that La, Ce and Nd were enriched in soil, hair and urine. Eu in smelting area showed a positive anomaly. In smelting and mining areas, females were more likely than male to expose to REEs. The relationship between REEs concentration and age group showed that hair’s high concentrations of REE existed in 18–40 years age for people from smelting areas and females from mining areas. While high concentrations distributed in the age of 41–65 for males from mining area. However, urine did not present similar distribution for different age group. Compared with hair and urine, soil showed the same distribution of REEs. And according to the Ce/Ce＊ value vs. LaN/YbN ratio showed that hair and soil tended to increase, with the stability of Ce/Ce＊ value. Thus the distri-bution of REEs in soil was closely related with the accumulation in human body. This is a preliminary study which may be suggested to the other research, and this study data may be useful for adding up the data pool on REEs levels in China.

关键词： rare earth elements soil human exposure anomaly age groups

Perception of pleasure in the urban running environment with street view images and running routes

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Journal of Geographical Sciences 2022年第12期32卷 2624-2640页

作者： ZHANG An SONG Liuyi ZHANG Fan State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchCASBeijing 100101China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100190China Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina

The urban environment affects human behavior and *** studies on the feelings of street spaces have not considered a specific kind of realistic scene,such as *** overcome this limitation,we explored the relationship between the urban environment and the pleasure of *** collected 8260 street view images from 153 running routes in Beijing and invited more than 400 volunteers of different genders and ages to rate their sense of pleasure in street view images of the urban running environment through an online ***,the proportion of visual elements in street images was extracted based on semantic segmentation,and the landscape was ***,a linear mixed model was used to predict the pleasure scores of different gender and age groups for different *** results show significant differences in the pleasure scores for different landscapes and age ***-aged people’s sense of pleasure was lower than that of the young and the *** greenery was associated with a higher pleasure score,while the proportion of urban elements such as buildings was negatively correlated with the pleasure *** results indicate that running in a natural landscape is pleasurable and beneficial for mental health.

关键词： pleasure assessment running routes street view landscape types age groups

Effects of rodent-induced disturbance on eco-physiological traits of Haloxylon ammodendron in the Gurbantunggut Desert,Xinjiang,China

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Journal of Arid Land 2020年第3期12卷 508-521页

作者： XIANG Yanling WANG Zhongke LYU Xinhua HE Yaling LI Yuxia ZHUANG Li ZHAO Wenqin College of Life Sciences Shihezi UniversityShihezi 832003China School of Medicine Shihezi UniversityShihezi 832003China

Disturbance by rodents alters the morphologies and nutrients of plants as well as the physical-chemical properties of the *** in plants are considered to be mechanisms of defense against the disturbance by *** gnaw on the assimilating branches of Haloxylon ammodendron(CA Mey.)Bunge and burrow under the bushes in the desert ecosystems of Xinjiang,***,eco-physiological responses of different age groups of *** to the disturbance by rodents are not well *** this study,soil physical-chemical properties under the shrubs and the above-ground morphological,physiological and biochemical features of assimilating branches of *** of different age groups(i.e.,young,30−100 cm;middle-aged,100−200 cm;and mature,>200 cm)in burrowed and non-burrowed(control)areas were studied in *** found that disturbance by rodents significantly increased the crown width and total branching rates of young and middle-aged *** pigment contents of assimilating branches of *** were significantly reduced under the disturbance by *** term of plant nutrients,the main differences among different age groups of *** under the disturbance by rodents occurred in the total soluble sugar and reducing sugar contents that decreased in young plants,increased in middle-aged plants,and did not affect in mature *** protein and phosphorus contents significantly increased,while crude fiber and calcium contents significantly decreased in young *** fat and calcium contents significantly decreased in middle-aged *** organic matter(SOM),total nitrogen(TN),available nitrogen(AN)and available potassium(AK)contents in the topsoil(0–20 cm),which are conducive to forming''fertile islands'',also increased under the disturbance by *** particular,soil AN and AK were the major factors affecting the above-ground morphological characteristics of *** in burrowed ***,the

关键词： age groups morphology assimilating branches soil physical-chemical properties photosynthetic pigments

Community-based cross-sectional seroprevalence study of hepatitis A in Bangladesh

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World Journal of Gastroenterology 2009年第39期15卷 4932-4937页

作者： Samir K Saha Setarunnahar Saha Salim Shakur Mohammed Hanif Md Ahsan Habib Sanjoy K Datta Hans L Bock Bangladesh Institute of Child Health Dhaka Shishu Hospital Institute of Public Health Glaxo-SmithKline Biologicals 89 Rue de l'Institut

AIM： TO elucidate the age-distribution of anti-hepatitis A virus （HAY） seroprevalence across different socioeconomic status （SES） categories in Bangladesh which, despite scarce data, is generally deemed to have high endemicity. METHODS： Blood samples of 818 subjects from a stratified samp#e of schools and hospitals, comprising different age categories and SES were collected. They were assayed for total anti-HAV antibodies. Social and medical history data were obtained using a questionnaire. RESULTS： Overall anti-HAV seroprevalence was 69.6%, increasing with age from 1-5 years （40.4%） to 〉 30 years （98.4%）. Seroprevalence was lowest （49.8%） in the high SES group and highest （96.5%） in the rural lower-middle SES group. Among subjects aged 6-20 years, anti-HAV seroprevalence was lowest in urban private school children （43.0%）, followed by urban government school children （76.2%） and rural school children （96.5%）（P 〈 0.01）. Within the high SESgroup, anti-HAV seroprevalence was 32.3% in subjects 〈 10 years and 51.7% in those aged 11-20 years. Until now Bangladesh has been deemed to have high endemicity for HAV. CONCLUSION： The transition from high to intermediate HAV endemicity may be underway; high SES adolescents and adults remain particularly at risk of symptomatic illness. Preventive measures need consideration.

关键词： age groups Hepatitis A virus Hepatitis A virus seroprevalence Anti-hepatitis A virus antibodies Socioeconomic groups

Efficacy of Intragastric Balloons in the Markers of Metabolic Dysfunction-associated Fatty Liver Disease:Results from Meta-analyses

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Journal of Clinical and Translational Hepatology 2021年第3期9卷 353-363页

作者： Zi-Yuan Zou Jing Zeng Tian-Yi Ren Yi-Wen Shi Rui-Xu Yang Jian-Gao Fan Center for Fatty Liver Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Key Lab of Pediatric Gastroenterology and NutritionShanghaiChina

Background and Aims:Nonalcoholic fatty liver disease,now renamed metabolic dysfunction-associated fatty liver disease(MAFLD),is common in obese *** balloon(IGB),an obesity management tool with low complication risk,might be used in MAFLD treatment but there is still unexplained heterogeneity in results across ***:We conducted a systematic search of 152 citations published up to September ***-analyses,stratified analyses,and meta-regression were performed to evaluate the efficacy of IGB on homeostasis model assessment of insulin resistance(HOMA-IR),alanine aminotransferase(ALT),aspartate aminotransferase(AST),and gamma-glutamyl transpeptidase(GGT),and to identify patients most appropriate for IGB ***:Thirteen observational studies and one randomized controlled trial met the inclusion criteria(624 participants in total).In the overall estimate,IGB therapy significantly improved the serum markers change from baseline to follow-up[HOMA-IR:1.56,95%confidence interval(CI)=1.16–1.95;ALT:11.53 U/L,95%CI=7.10–15.96;AST:6.79 U/L,95%CI=1.69–11.90;GGT:10.54 U/L,95%CI=6.32–14.75].In the stratified analysis,there were trends among participants with advanced age having less change in HOMA-IR(1.07 vs.1.82).The improvement of insulin resistance and liver biochemistries with swallowable IGB therapy was no worse than that with endoscopic *** meta-regression analyses showed that greater HOMA-IR loss was predicted by younger age(p=0.0107).Furthermore,effectiveness on ALT and GGT was predicted by basal ALT(p=0.0004)and GGT(p=0.0026),***:IGB is effective among the serum markers of *** patients had a greater decrease of HOMA-IR after IGB therapy.

关键词： Intragastric balloon Nonalcoholic fatty liver disease Insulin resistance age groups Treatment outcome

Repercussion of salinity on hematological parameters and tissue morphology of gill and kidney at early life of tilapia

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Aquaculture and Fisheries 2024年第2期9卷 256-264页

作者： Azhar Ali Md Golam Azom Bhakta Supratim Sarker Hasu Rani Md Samsul Alam m.sadiqul islam*department of fisheries biology and genetics bangladesh agricultural universitymymensingh2202bangladesh

This study was attempted to reveal the changes in three hematological parameters such as blood hemoglobin,number of white blood cells(WBCs)and number of red blood cells(RBCs)and one biochemical(e.g.,glucose)parameter along with the changes in histomorphological structures of gills and kidney of Nile tilapia fry reared in saline *** experimental set up were used for two different age groups-5 days-after-hatch(5DAH)and 15 days-after-hatch(15DAH)-to test a novel hypothesis:if a little difference in the age during the first exposure to saline water could produce any variation in the *** were placed into 6 plastic drums having six different salinity levels:0,5,10,15,20 and *** 60 days,at least 5 individuals were taken out from each drum to observe the above-hematological and histomorphological parameters.A two-way-ANOVA revealed that,except for hemoglobin,all the observed parameters have been affected the effect of age×salinity interaction(Page groups,only the overall average glucose value and RBC count were significantly *** various salinity levels,only RBC and WBC counts differed ***,the mean glucose value,RBC counts and WBC count at different salinities differed significantly from the base mean value of each *** regard to the histomorphological structure of the gills and kidney,various malformations were *** hypertrophy,epithelial uplifting and epithelial necrosis were present as gill degenerations,hyperplasia was prevalent across almost all salinity *** the other hand,glomerular necrosis,pyknotic nucleus,hyaline droplets degeneration,shrinking of the glomeruli,*** observed in kidney *** assisting to understand the effects of salinity stress,all these data on tilapia fry will help to determine the prospects and scope of culturing the species in high-salinity water.

关键词： Nile tilapia Salinity Blood parameters Histomorphology age groups

Mathematical models for assessing vaccination scenarios in several provinces in Indonesia

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Infectious Disease Modelling 2021年第1期6卷 1236-1258页

作者： N.Nuraini K.K.Sukandar P.Hadisoemarto H.Susanto A.I.Hasan N.Sumarti Department of Mathematics Institut Teknologi BandungBandung40116Indonesia Department of Public Health Faculty of MedicinePadjadjaran UniversityJatinangor45363Indonesia Department of Mathematics Khalifa UniversityP.O.Box 127788Abu DabhiUAE Department of Mathematical Sciences University of EssexWivenhoe ParkColchesterCO43SQUnited Kingdom Department of ICET and Natural Sciences Faculty of Information Technology and Electrical EngineeringAnkeretÅlesundLarsgådsvegen 26009Norway

To mitigate casualties from the COVID-19 outbreak,this study aims at assessing the optimal vaccination scenarios,considering several existing healthcare conditions and assumptions,by developing SIQRD(Susceptible-Infected-Quarantine-Recovery-Death)models for Jakarta,West Java,and Banten,in *** models include an age-structured dynamic transmission model that naturally allows for different treatments among different age groups of the *** simulation results show that the timing and period of the vaccination should be well planned and prioritizing particular age groups will give a significant impact on the total number of casualties.

关键词： COVID-19 SIQRD model age groups Healthcare capacity Vaccination strategy