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Blood-brain barrier and cerebral blood flow: age differences in hemorrhagic stroke

Journal of Innovative Optical Health Sciences 2015年第6期8卷 101-110页

作者： Semyachkina-Glushkovskaya Oxana Sindeeva Olga Abdurashitov Arkady Sindeev Sergey Zinchenko Ekaterina Gekaluk Artem Ulanova Maria Mohanad Kassim Yankovskaya Ludmila Tuchin Valery Department of Physiology of Human and Animals Saratov State University Astrakhanskaya Str.83 Saratov 410012Russia Department of Optics and Biophotonics Saratov State University Astrakhanskaya Str.83 Saratov 410012Russia Department of Therapy Grodno Medical State University Limozha Str.23Grodno 230005Byelorussia Laboratory of Biophotonics Tomsk State University Tomsk 634050Russia

Neonatal stroke is similar to the stroke that occurs in adults and produces a significant morbidity and long-term neurologic and cognitive *** are important differences in the factors,clinical events and outcomes associated with the stroke in infants and ***,mechanisms underlying age differences in the stroke development remain largely ***,treatment guidelines for neonatal stroke must extrapolate from the adult data that is often not suitable for *** new information about differences between neonatal and adult stroke is essential for identification of significant areas for future treatment and effective prevention of neonatal ***,we studied the development of stress-induced hemorrhagic stroke and possible mechanisms underlying these processes in newborn and adult *** histological methods and magnetic resonance imaging,we found age differences in the type of intracranial *** rats demonstrated small superficial bleedings in the cortex while adult rats had more severe deep bleedings in the *** Doppler optical coherent tomography,we found higher stress-reactivity of the sagittal sinus to deleterious effects of stress in newborn *** rats suggesting that the cerebral veins are more vulnerable to negative stress factors in neonatal *** brain in ***,adult but not newborn rats demonstrated the stroke-induced breakdown of blood brain barrier(BBB)*** one of possible mechanisms underlying the higher resistance to stress-related stroke injures of cerebral vessels in newborn rats compared with adult animals is the greater expression of two main tight junction proteins of BBB(occludin and claudin-5)in neonatal *** brain in rats.

关键词： Stroke age di®erences cerebral blood flow brain blood barrier

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