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SIP30 in the ventrolateral orbital cortex contributes to affective pain in rat

SIP30 in the ventrolateral orbital cortex contributes to aff...

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中国神经科学学会第十二届全国学术会议

作者： Ru-Yi Huang Mei Han Zhi-Qi Zhao Hong Cao Yu-Qiu Zhang Institutes of Brain Science and State Key Laboratory of Medical Neurobiology Fudan University

Objective SIP30（SNAP25 interacting protein of 30）, interacting with SNAP25, is widely expressed in the mammal brain and plays a role in neural activities. Our previous studies demonstrated that SIP30 in the r ACC mediates neuropathic pain-evoked negative emotion via modulation of glutamate release and excitatory synaptic transmission. Here, using a chronic constriction injury（CCI） model of neuropathic pain, we aim to explore the role of SIP30 in the ventrolateral orbital cortex（VLO） in painrelated negative emotion. Methods Rats were performed in a chamber with one half painted white（light area） and the other half painted black（dark area）, and measured neuropathic pain-evoked place escape/avoidance paradigm（PEAP） to quantify the level of negative emotion evoked by painful stimuli using a von Frey hair. Results Bilateral excitotoxic（quinolinic acid 200 nmol/ml） lesions of the VLO significantly blocked the formation of pain-related emotion without influence on CCI-induced mechanical allodynia and heat hyperalgesia. CCI induced a bilateral increase of SIP30 in the VLO. Upregulated SIP30 is predominantly colocalized with Neu N, a neuronal marker, but not with GFAP, an astrocyte marker, or OX-42, a microglial marker. Inhibition of CCImediated induction of SIP30 by intra-VLO injection of sh RNA targeting the rat sip30 gene reduced affective pain in the PEAP test. Interestingly, knockdown of SIP30 did not affect CCI-induced evoked pain hyperalgesia. Neither did it affect general learning and memory. Conclusion The present study strongly suggests that SIP30 in the ventrolateral orbital cortex plays an important role in neuropathic pain-evoked aversion.

关键词： ventrolateral orbital cortex neuropathic pain affective pain SIP30

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Electroacupuncture Alleviating the affective pain via δ-opioid Receptor in Anterior Cingulate Cortical Neurons in Rats

Electroacupuncture Alleviating the Affective Pain via δ-opi...

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中国神经科学学会第十二届全国学术会议

作者： Yang MA Guo-Hua QIN Xin ZHAO Zhi-Hua WANG Jie-Qiong DAI Xin JIA Zhen-Ying DU Xiao-Ya GUAN Jian-Guo LI Ce ZHANG Yu ZHANG Departmen of Physiology Shanxi Medical University Departmen of Pathology Shanxi Medical University

Objective The sensory and emotional responses of pain are produced by different central mechanisms and are mediated by different neurotransmission pathways. The studies of Human and animal behavior, electrophysiology, brain imaging and other related technologies have provided evidence that the anterior cingulate cortex（ACC）, which locates in the frontal lobe of the brain, involves in chronic inflammation-induced disgust formation, and plays an important role in the behavioral responses of adverse emotions, especially in the rostral ACC（r ACC）. Previous studies have shown that electroacupuncture（EA） can relieve the affective pain through activation of μ-opioid receptor in r ACC brain area in rats, but it is not clear whether the pain can be relieved by activating δ-opioid receptor in r ACC. Methods A rat model of complete Freund’s adjuvant（CFA） induced conditional position avoidance（C-CPA） was used in this experiment. Different concentrations（1/2.5/5/10 μg/μl） of naltrindole, a δ-opioid receptor antagonist, were respectively microinjected into r ACC brain area in rats before EA（10 Hz,3 m A,0.1 ms） or sham EA stimulation in Huantiao acupoint（GB30）. Then we measured C-CPA responses and heat pain behavior（paw withdrawal latency, PWL）, and the expression of δ-opioid receptor and the phosphorylation of NR1/NR2 A/NR2 B subunit in r ACC subsequently were detected. Results（1） Subcutaneous injection of CFA significantly reduced the time of PWL.（2） In the painful environment, CFA rats stayed less time than in the non-painful environment.（3） EA stimulation relieved C-CPA responses in rats.（4） Naltrindole administrated at the dose of 5 or 10μg/μl in r ACC markedly reversed the role of EA relieving C-CPA responses, but the dose of 1/2.5 μg/μl had no obvious effect.（5） The phosphorylation of NR1/NR2 A/NR2 B subunit in r ACC was consistant with the change trends of CPA responses.（6） After EA stimulation, the expression of δ-opioid receptor in r ACC was significantly up-regulated in

关键词： conditioned place avoidance(CPA) affective pain rostral anterior cingulate cortex(r ACC) δ-opioid receptor electroacupuncture(EA)

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Involvement of the anterior cingulate cortex in pain-related negative emotion

Involvement of the anterior cingulate cortex in pain-related...

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中国生理学会第24届全国会员代表大会暨生理学学术大会

作者：张玉秋复旦大学

The pain experience includes a sensory-discriminative and an affective-emotional *** anterior cingulate cortex（ACC）is thought to be key neural substrates underlying emotional *** pain-related conditioned place avoidance models（CPA）,we observed that bilateral excitotoxic lesions of the ACC significantly suppressed the formalin-induced CPA（F-CPA）.Neither formalin-induced acute nociceptive behaviors nor electrical foot shock-induced CPA was affected by lesions of *** results suggest that the ACC might play a critical role in the pain-related negative ***,we observed the effect of N-methyl-D-aspartate（NMDA）and a-amino-3-hydroxy-5-methyl-isoxozole propionic acid/kainite（AMPA/KA）receptors on pain-related ***-ACC NMDA receptors antagonist,2-amino-5-phosphonovalerate（AP5）,but not AMPA/KA receptors antagonist DNQX F-CPA was effectively *** contrast,the intra-ACC or icv injection of DNQX failed to alter the conditioning scores of ***,NMDA-evoked currents in ACC,especially rostral ACC（r ACC）neurons were significantly greater in formalin-injected rats than in naive or normal saline injected *** blocking either NR2A or NR2B subunit in the r ACC abolished the acquisition of F-CPA and formalin nociceptive conditioning-induced Fos expression,suggesting that NMDA receptors including NR2A and NR2B subunits in the r ACC are preferentially involved in the processing of the affective dimension of *** receptor activation induced p PKA,p ERK and p CREB in r ACC *** formalin injection produced ERK activation in r ACC *** of PKA and ERK activation in the r ACC prevented the induction of ***,NMDA-PKA-ERK-CREB pathway activation in the r ACC is required for the induction and expression of pain-related negative *** has been reported to enhance NMDA-mediated synaptic activity in the hippocampus and *** demonstrated that estrogen acutely enhanced th

关键词： Anterior Cingulate Cortex affective pain NMDA receptor SIP 30 Estrogen

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