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Genomic predictors for treatment of late stage prostate cancer

Asian Journal of Andrology 2016年第4期18卷 586-591页

作者： Daniel H Shevrin Department of Medicine Division of Hematology/Oncology NorthShore University HealthSystem 2650 Ridge Avenue Evanston Illinois 60201 USA

In spite of the development of new treatments for late stage prostate cancer, significant challenges persist to match individuals with effective targeted therapies. Genomic classification using high-throughput sequencing technologies has the potential to achieve this goal and make precision medicine a reality in the management of men with castrate-resistant prostate cancer. This chapter reviews some of the most recent studies that have resulted in significant progress in determining the landscape of somatic genomic alterations in this cohort and, more importantly, have provided clinically actionable information that could guide treatment decisions. This chapter reviews the current understanding of common alterations such as alterations of the androgen receptor and PTEN pathway, as well as ETS gene fusions and the growing importance of PARP inhibition. It also reviews recent studies that characterize the evolution to neuroendocrine tumors, which is becoming an increasingly important clinical problem. Finally, this chapter reviews recent innovative studies that characterize the compelling evolutionary history of lethal prostate cancer evidenced by polyclonal seeding and interclonal cooperation between metastasis and the importance of tumor clone dynamics measured serially in response to treatment. The genomic landscape of late stage prostate cancer is becoming better defined, and the prospect for assigning clinically actionable data to inform rationale treatment for individuals with this disease is becoming a reality.

关键词： advanced prostate cancer genomic alterations lethal prostate cancer precision medicine targeted therapy whole-genomesequencing

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Identifying the role of apolipoprotein A-I in prostate cancer

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Asian Journal of Andrology 2021年第4期23卷 400-408页

作者： Jing Wang Ling-Fan Xu Cheng Liu Tao Huang Chao-Zhao Liang Yi-Dong Fan Department of Urology Qilu HospitalCheeloo College of MedicineShandong UniversityJinan 250012China Department of Urologic Oncology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230036China Department of Urology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022China

Although localized prostate cancer(PCa)can be cured by prostatectomy and radiotherapy,the development of effective therapeutic approaches for advanced prostate cancer,including castration-resistant PCa(CRPC)and neuroendocrine PCa(NEPC),is lagging far *** a novel prognostic and diagnostic biomarker for early diagnosis and intervention is an urgent clinical ***,we report that apolipoprotein A-I(ApoA-I),the major component of high-density lipoprotein(HDL),is upregulated in PCa based on both bioinformatics and experimental *** fact that advanced PCa shows strong ApoA-I expression reflects its potential role in driving therapeutic resistance and disease progression by reprogramming the lipid metabolic network of tumor ***,ApoA-I is regulated by MYC,a frequently amplified oncogene in late-stage ***,our findings have revealed a novel indicator to predict prognosis and recurrence,which would benefit patients who are prone to progress to metastasis or even NEPC,which is the lethal subtype of PCa.

关键词： advanced prostate cancer apolipoprotein A-I lipid metabolism MYC

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