检索结果-南通市图书馆

河北科技师范学院学报 2011年第2期25卷 75-80页

作者：李娟沈飞陈巍燕山大学体育学院河北秦皇岛066004 河北科技师范学院体育系

从adipokines与胰岛素抵抗的关系,adipokines与肥胖者脂肪组织巨噬细胞浸润,炎症与胰岛素抵抗信号转导,内质网应激与胰岛素抵抗等方面综述了adipokines在肥胖症及胰岛素抵抗中的作用;并着重探讨了肥胖,adipokines,炎症,胰岛素抵抗四者... 详细信息

从adipokines与胰岛素抵抗的关系,adipokines与肥胖者脂肪组织巨噬细胞浸润,炎症与胰岛素抵抗信号转导,内质网应激与胰岛素抵抗等方面综述了adipokines在肥胖症及胰岛素抵抗中的作用;并着重探讨了肥胖,adipokines,炎症,胰岛素抵抗四者之间的关系。

关键词： adipokine 肥胖症胰岛素抵抗

Human chemerin induces eryptosis at concentrations exceeding circulating levels

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

BIOCELL 2024年第8期48卷 1197-1208页

作者： MARYNA TKACHENKO ANATOLII ONISHCHENKO LILIYA TRYFONYUK DMYTRO BUTOV KATERYNA KOT VIKTORIIA NOVIKOVA LIWEI FAN VOLODYMYR PROKOPIUK YURII KOT ANTON TKACHENKO Department of Internal Medicine No.2 Clinical Immunology and AllergologyKharkiv National Medical UniversityKharkiv61022Ukraine Research Institute of Experimental and Clinical Medicine Kharkiv National Medical UniversityKharkiv61022Ukraine Institute of Health National University of Water and Environmental EngineeringRivne61022Ukraine Department of Infectious Diseases and Phthisiology Kharkiv National Medical UniversityKharkiv61022Ukraine Biochemistry Department V.N.Karazin Kharkiv National University Ministry of Education and Science of UkraineKharkiv61022Ukraine Department of Chemistry BiochemistryMicrobiology and Food HygieneState Biotechnological UniversityKharkiv61022Ukraine Clinical Research Innovation Lab Floor 26 Block D Qidi Technology Building 8Tsinghua Technology ParkBeijing100084China Department of Cryobiochemistry Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of UkraineKharkiv61015Ukraine

Introduction:Human chemerin is an adipokine that regulates chemotaxis,inflammation,and glucose *** addition,accumulating evidence suggests that chemerin promotes apoptosis,autophagy,and ***,there are no data on its impact on *** current study aimed to analyze the effects of human active Glu^(21)-Ser^(157) chemerin on eryptosis in *** and Methods:Human chemerin 0-2-10-50μg/mL was incubated for 24 h with human erythrocytes(hematocrit 0.4%)obtained from eight healthy *** cytometry-based determination of phospholipid scrambling,reactive oxygen species(ROS)production,and intracellular Ca^(2+)levels was *** supplement data on ROS and Ca^(2+)signaling in chemerin-mediated eryptosis,incubation in the presence or absence of antioxidants vitamin C and N-acetylcysteine and Ca^(2+)-binding agent EGTA was carried out,*** microscopy-based techniques were used to detect reactive nitrogen species(RNS)generation,involvement of caspase-3 and caspase-8,as well as the state of lipid order in cell membranes of erythrocytes exposed to human Glu^(21)-Ser^(157) ***:Our observations suggest that human Glu^(21)-Ser^(157) chemerin had no impact on eryptosis parameters at 2μg/***,chemerin stimulated phosphatidylserine externalization,ROS production,and Ca^(2+)accumulation at higher concentrations suggesting activation of ***^(2+)uptake turned out to be at least partly required for chemerin-mediated ***-mediated erythrotoxicity was additionally mediated by RNS,caspase-3,and ***,Glu^(21)-Ser^(157) chemerin promoted reduction in the liquid-ordered phase of cell membranes in ***:The present study first discloses that human chemerin can induce eryptosis via Ca^(2+)-dependent mechanisms at concentrations noticeably exceeding circulating ***,chemerin-induced eryptosis can hardly contribute to eryptosis-mediated anemia in disease

关键词： adipokine Cell death Chemerin Oxidative stress Eryptosis

Abnormal adipokines Associated with Various Types of Obesity in Chinese Children and Adolescents

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2011年第1期24卷 12-21页

作者： ZHANG MeiXian ZHAO XiaoYuan LIMing CHENG Hong HOU DongQing WEN Yu Katherine CIANFLONE MI Jie Department of Epidemiology Capital Institute of Pediatrics Beijing 100020 China Department of Endocrinology Peking Union Medical College Hospital Peking Union Medical College and ChineseAcademy of Medical Sciences Beijing 100730 China Department of Pediatrics Tongji HospitalHuaZhong University of Science and Technology Wuhan 430030 Hubei China Centre de Recherche Institut Universitaire de Cardiologie et Pneumologie de Quebec Universite Laval Quebec Canada

Objective To explore the role of adipokines including insulin, resistin, leptin, adiponectin, acylation stimulating protein （ASP） and complement C3 （C3） in various types of obesity （peripheral obesity, abdominal obesity and mixed obesity） in Chinese children and adolescents, and their relationships with body size and pubertal development. Methods Children and adolescents （n=3 508） aged 6 to 18 years, with 1 788 boys and 1 720 girls were assessed for body mass index, waist circumference, pubertal development, blood insulin, resistin, leptin, adiponectin, ASP and C3 levels. Three types of obesity [peripheral obesity （n=43）, abdominal obesity （n=473）, mixed obesity （n=1 187）] and non‐obese control （n=1 805） were defined with combined use of Chinese body mass index and waist circumference criteria. Results Serum resistin, leptin and adiponectin levels were higher in girls than those in boys （all P0.01）. Insulin and leptin increased and adiponectin decreased across five Tanner stages in both girls and boys （all P0.001）, while ASP changed only in girls （P0.001） and C3 only in boys （P0.001）. Insulin, leptin and ASP were higher, but adiponectin was lower in all three types of obesity vs. the non‐obese control （all P0.05）. The greatest abnormalities of all six adipokines were found in the mixed obesity group. With inclusion of body mass index and waist circumference in simultaneous regression analyses, both body size indices were independently and significantly correlated with insulin, leptin and adiponectin after age and gender adjustment. Compared with waist circumference, the body mass index was stronger in interpreting insulin, leptin, adiponectin and ASP levels, whereas it was weaker in explaining variance of plasma C3. Conclusions Obese children have a worse metabolic profile with high insulin, resistin, leptin, ASP and C3, and low adiponectin levels. The adipokine profile in mixed obesity is worse than that in peripheral or abdominal obesity. Identification of obese s

关键词： adipokine Types of obesity Body mass index Waist circumference Child and adolescent Chinese

Adiponectin and metabolic cardiovascular diseases:Therapeutic opportunities and challenges

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2023年第4期10卷 1525-1536页

作者： Xiaotian Lei Sheng Qiu Gangyi Yang Qinan Wu Endocrinology Department The Second Affiliated Hospital of the Chongqing Medical UniversityChongqing 400000China Endocrinology Department The First Affiliated Hospital of the Army Medical UniversityChongqing 400038China Endocrinology Department Dazu Hospital of Chongqing Medical UniversityThe People’s Hospital of DazuChongqing 402360China

Metabolic cardiovascular diseases have become a global health concern,and some of their risk factors are linked to several metabolic *** are the leading causes of death in developing *** tissues secrete a variety of adipokines that participate in regulating metabolism and various pathophysiological *** is the most abundant pleiotropic adipokine and can increase insulin sensitivity,improve atherosclerosis,have anti-inflammatory properties,and exert a cardioprotective *** adiponectin con-centrations are correlated with myocardial infarction,coronary atherosclerotic heart disease,hypertrophy,hypertension,and other metabolic cardiovascular ***,the relationship between adiponectin and cardiovascular diseases is complex,and the specific mechanism of action is not fully *** summary and analysis of these issues are ex-pected to contribute to future treatment options.

关键词： adipokine Adiponectin Inflammation Metabolic cardiovascular disease Obesity

Insulin resistance and adipose tissue interactions as the cornerstone of metabolic(dysfunction)-associated fatty liver disease pathogenesis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2023年第25期29卷 3999-4008页

作者： Shreya C Pal Nahum Méndez-Sánchez Faculty of Medicine National Autonomous University of MexicoMexico City 04510Mexico Liver Research Unit Medica Sur Clinic&FoundationMexico City 04510Mexico

The relationship between metabolic derangements and fatty liver development are undeniable,since more than 75% of patients with type 2 diabetes mellitus present with fatty *** is also significant epidemiological association between insulin resistance(IR)and metabolic(dysfunction)-associated fatty liver disease(MAFLD).For little more than 2 years,the nomenclature of fatty liver of non-alcoholic origin has been intended to change to MAFLD by multiple *** a myriad of reasons for which MAFLD is thought to be of metabolic origin could be exposed,the bottom line relies on the role of IR as an initiator and perpetuator of this *** is a reciprocal role in MAFLD development and IR as well as serum glucose concentrations,where increased circulating glucose and insulin result in increased de novo lipogenesis by sterol regulatory elementbinding protein-1c induced lipogenic enzyme stimulation;therefore,increased endogenous production of *** same effect is achieved through impaired suppression of adipose tissue(AT)lipolysis in insulin-resistant states,increasing fatty acid influx into the *** complementary reciprocal situation occurs when liver steatosis alters hepatokine secretion,modifying fatty acid metabolism as well as IR in a variety of tissues,including skeletal muscle,AT,and the *** aim of this review is to discuss the importance of IR and AT interactions in metabolic altered states as perhaps the most important factor in MAFLD pathogenesis.

关键词： Metabolic(dysfunction)-associated fatty liver disease Insulin resistance Adipose tissue Fatty liver Metabolic syndrome adipokine

Liver-adipose tissue crosstalk in alcohol-associated liver disease: The role of mTOR

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Liver Research 2022年第4期6卷 227-237页

作者： Yssa Rodriguez Jack Dunfield Tyson Roderique Hong-Min Ni Department of Pharmacology Toxicology and TherapeuticsUniversity of Kansas Medical CenterKansas CityKSUSA

Background:Alcohol-associated liver disease(ALD)is a major chronic liver disease around the world without successful *** alcoholic hepatitis is one of the most severe forms of ALD with high mortality,which is often associated with binge *** drinking dysregulates lipid metabolism,increases adipose tissue lipolysis,and induces liver steatosis and adipose tissue *** ev-idence implicates that crosstalk of liver and adipose tissue in the pathogenesis of *** target of rapamycin(mTOR)is a phosphatidylinositol 3-kinase(PI3K)-like serine/threonine protein kinase that regulates lipid metabolism,cell proliferation and ***,the role of mTOR in regulating adipose-liver crosstalk in binge drinking-induced organ damage remains ***:We generated liver-specific and adipocyte-specific regulatory-associated protein of mTOR(Rptor)knockout(Rptor LKO and Rptor AKO)as well as Mtor knockout(Mtor LKO and Mtor AKO)mice,by crossing Rptor flox and Mtor flox mice with albumin Cre or adiponectin Cre mice,*** addition,we generated liver and adipocyte double deletion of Rptor or Mtor(Mtor LAKO and Rptor LAKO)*** knockout mice with their matched wild-type littermates(Rptor WT and Mtor WT)were subjected to acute gavage of 7 g/kg ***:Mice with adipocyte deletion of Rptor or Mtor developed hepatomegaly and adipose tissue *** gavage increased liver injury,hepatic steatosis and inflammation in mouse livers as demonstrated by elevated serum alanine aminotransferase activities,increased hepatic levels of tri-glyceride and increased hepatic numbers of CD68 positive macrophages in mouse livers after alcohol *** injury was further exacerbated by deletion of adipocyte Rptor or *** adipokine array analysis revealed that increased levels of pro-inflammatory cytokines IL-6 and TNF a as well as chemokine MCP-1 following acute alcohol gavage in wild-type mice,which were further incr

关键词： Alcohol-associated liver disease(ALD) Liver injury Mechanistic target of rapamycin(mTOR) Adipose atrophy adipokine Liver-adipose tissue crosstalk

Serum omentin-1 is correlated with the severity of liver disease in patients with chronic hepatitis C

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2023年第12期15卷 1315-1324页

作者： Georg Peschel Kilian Weigand Jonathan Grimm Martina Müller Christa Buechler Department of Internal Medicine I University Hospital RegensburgRegensburg 93053Germany Department of Internal Medicine Klinikum FürstenfeldbruckFürstenfeldbruck 82256Germany Department of Gastroenterology Gemeinschaftsklinikum MittelrheinKoblenz 56073Germany

BACKGROUND Patients with chronic hepatitis C virus(HCV)infection have increased serum ***-1 is an anti-inflammatory adipokine,and higher levels may be a direct effect of HCV *** elimination of HCV by direct acting antivirals almost normalized circulating levels of various molecules with a role in *** To evaluate the effect of HCV infection on serum omentin-1,serum omentin-1 levels of HCV patients were measured before therapy and at 12 wk after therapy *** of serum omentin-1 with parameters of inflammation and liver function were explored at both time *** omentin-1 levels of patients with and without liver cirrhosis,which was defined by ultrasound or the fibrosis-4(FIB-4)score,were *** Serum omentin-1 levels were measured by enzyme-linked immunosorbent assay in 84 chronic HCV patients before therapy and at 12 wk after therapy end where sustained virological response 12(SVR12)was achieved in all *** omentin-1 of 14 non-infected controls was measured in *** In patients with chronic HCV,serum omentin-1 levels were not related to viral load or viral *** patients with liver steatosis and HCV patients with diabetes had serum omentin-1 levels comparable to patients not suffering from these *** omentin-1 levels at SVR12 were similar in comparison to pretreatment *** addition,serum levels did not differ between HCV-infected patients and non-infected *** omentin-1 levels did not correlate with leukocyte count or C-reactive *** correlations of serum omentin-1 with bilirubin and the model for end-stage liver disease score(MELD)were detected before therapy and at SVR12 in the whole *** and the MELD score also positively correlated with serum omentin-1 levels in the subgroup of patients with ultrasound diagnosed liver cirrhosis before *** SVR12,serum omentin-1 levels of patients with liver cirrhosis negativel

关键词： Direct acting antivirals Hepatitis C Liver cirrhosis adipokine

Interplay of adipokines and myokines in cancer pathophysiology: Emerging therapeutic implications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Experimental Medicine 2013年第3期3卷 26-33页

作者： Maria Dalamaga Department of Clinical Biochemistry Medical School University of Athens "Attikon" General University Hospital 12462 Athens Greece

Excess body weight constitutes a worldwide health problem with epidemic proportions impacting on the risk and prognosis of several disease states including malignancies. It is believed that the metabolic changes associated with weight gain, particularly visceral obesity, and physical inactivity could lead to dysfunctional adipose and muscle tissues causing insulin resistance, low-grade chronic inflammation and abnormal secretion of adipokines and myokines. The complex paracrine and endocrine interconnection between adipokines and myokines reflects a yin-yang balance with important implications in processes such as lipolysis control, insulin sensitivity and prevention from obesity-driven chronic low-grade inflammation and cancer promotion through anti-inflammatory adipokines and myokines. Furthermore, the complex pathophysiology of cancer cachexia is based on the interplay between muscle and adipose tissue mediated by free fatty acids, various adipokines and myokines. The purpose of this editorial is to explore the role of the adipose and muscle tissue interplay in carcinogenesis, cancer progression and cachexia, and to examine the mechanisms underpinning their association with malignancy. Understanding ofthe mechanisms connecting the interplay of adipokines and myokines with cancer pathophysiology is expected to be of importance in the development of therapeutic strategies against cancer cachexia. Advances in the field of translational investigation may lead to tangible benefits to obese and inactive persons who are at increased risk of cancer as well as to cancer patients with cachexia.

关键词： adipokine Myokine Cancer Cachexia Interleukin-15 Interleukin-6 Obesity Myostatin

Serum adipokines might predict liver histology findings in non-alcoholic fatty liver disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第21期22卷 5096-5103页

作者： Raika Jamali Mohsen Razavizade Abbas Arj Mohammad Hossein Aarabi Research Development Center Sina Hospital Digestive Disease Research Institute Tehran University of Medical sciences Department of Internal Medicine Shahid Beheshti Hospital Kashan University of Medical Sciences Research Center for Biochemistry and Nutrition in Metabolic Disease Faculty of Medicine Kashan University of Medical Sciences

AIM: To assess significance of serum adipokines to determine the histological severity of non-alcoholic fatty liver ***: Patients with persistent elevation in serum aminotransferase levels and well-defined characteristics of fatty liver at ultrasound were enrolled. Individuals with a history of alcohol consumption, hepatotoxic medication, viral hepatitis or known liver disease were excluded. Liver biopsy was performed to confirm nonalcoholic liver disease(NAFLD). The degrees of liver steatosis, lobular inflammation and fibrosis were determined based on the non-alcoholic fatty liver activity score(NAS) by a single expert pathologist. Patients with a NAS of five or higher were considered to have steatohepatitis. Those with a NAS of two or lower were defined as simple fatty liver. Binary logistic regression was used to determine the independent association of adipokines with histological findings. Receiver operating characteristic(ROC) analysis was employed to determine cut-off values of serum adipokines to discriminate the grades of liver steatosis,lobular inflammation and fibrosis. RESULTS: Fifty-four participants aged 37.02 ± 9.82 were enrolled in the study. Higher serum levels of visfatin, IL-8, TNF-α levels were associated independently with steatosis grade of more than 33% [β = 1.08(95%CI: 1.03-1.14), 1.04(95%CI: 1.008-1.07), 1.04(95%CI: 1.004-1.08), P adipokines ma

关键词： Non-alcoholic fatty liver disease adipokine Histology Adiponectin Visfatin Resistin Hepcidin Interle