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Classification,biosynthesis,and biological functions of triterpene esters in plants

Plant Communications 2024年第4期5卷 67-93页

作者： Jia Liu Xue Yin Chengxi Kou Ramesha Thimmappa Xin Hua Zheyong Xue Key Laboratory of Saline-alkali Vegetation Ecology Restoration(Northeast Forestry University) Ministry of EducationHarbin 150040China Heilongjiang Key Laboratory of Plant Bioactive Substance Biosynthesis and Utilization Northeast Forestry UniversityHarbin 150040China Amity Institute of Genome Engineering Amity UniversityNoidaUP India 201313India State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Beijing 100700P.R.China

Triterpene esters comprise a class of secondary metabolites that are synthesized by decorating triterpene skeletons with a series of oxidation,glycosylation,and acylation *** triterpene esters with important bioactivities have been isolated and identified,including those with applications in the pesticide,pharmaceutical,and cosmetic *** also play essential roles in plant defense against pests,dis-eases,physical damage(as part of the cuticle),and regulation of root ***,there has been no recent summary of the biosynthetic pathways and biological functions of plant triterpene ***,we classify triterpene esters intofive categories based on their skeletons andfind that C-3 oxidation may have a significant effect on triterpenoid *** acid and aromatic moieties are common li-gands present in triterpene *** further analyze triterpene ester synthesis-related acyltransferases(TEsACTs)in the triterpene biosynthetic *** an evolutionary classification of BAHD acyltrans-ferases(BAHD-ATs)and serine carboxypeptidase-like acyltransferases(SCPL-ATs)in Arabidopsis thaliana and Oryza sativa,we classify 18 TEsACTs with identified functions from 11 *** the triterpene-skel-eton-related TEsACTs belong to BAHD-AT clades IIIa and I,and the only identified TEsACT from the SCPL-AT family belongs to the CP-I *** comprehensive review of the biosynthetic pathways and bioactivities of triterpene esters provides a foundation for further study of their bioactivities and applica-tions in industry,agricultural production,and human health.

关键词： triterpene esters acyltransferases classification biosynthesis biological functions

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GSTM1,GSTT1,GSTP1 and CYP1A1 genetic polymorphisms and susceptibility to esophageal cancer in a French population:Different pattern of squamous cell carcinoma and adenocarcinoma

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World Journal of Gastroenterology 2004年第23期10卷 3389-3393页

作者： Ahmed Abbas Karine Delvinquière Mathilde Lechevrel Pierre Lebailly Pascal Gauduchon Guy Launoy Fran ois Sichel GRECAN-EA1772 UFR des Sciences Pharmaceutiques Université de Caen Basse-Normandie et Centre Francois BaclesseAvenue du Général Harris14076 Caen cedex 05France GRECAN-EA1772 Université de Caen Basse-Normandie et Registre des Tumeurs Digestives du Calvados UFR de MédecineAvenue de la C te de Nacre14032 Caen cedexFrance

AIM:To evaluate the association between CYP1A1 and GSTs genetic polymorphisms and susceptibility to esophageal squamous cell carcinoma(SCC)and esophageal adenocarcinoma(ADC)in a high risk area of northwest of France. METHODS:A case-control study was conducted to investigate the genetic polymorphisms of these enzymes (CYPIAI*2C and GSTP1 exon 7 Val alleles,GSTMI*2/*2 and GSTTl *2/*2 null genotypes).A total of 79 esophageal cancer cases and 130 controls were recruited. RESULTS:GSTMI*2/*2 and CYPIAI*IA/*2C genotype frequencies were higher among squamous cell carcinomas at a level dose to statistical significance(OR =1.83,95% CI 0.88-3.83,P=0.11;OR=3.03,95% CI 0.93-9.90,P=0.07, respectively).For GSTP1 polymorphism,no difference was found between controls and cases,whatever their histological *** frequency of GSTT1 deletion was observed in ADC group compared to controls with a statistically significant difference(OR=13.31,95% CI 1.66-106.92,P<0.01). CONCLUSION:In SCC,our results are consistent with the strong association of this kind of tumour with tobacco *** ADC,our results suggest 3 distinct hypotheses: (1)activation of exogenous procarcinogens,such as small halogenated compounds by GSTT1;(2)contribution of GSTT1 to the inflammatory response of esophageal mucosa,which is known to be a strong risk factor for ADC, possibly through leukotriene synthesis;(3)higher sensitivity to the inflammatory process associated with intracellular depletion of glutathione.

关键词： acyltransferases Adenocarcinoma Adult Aged Aged, 80 and over Carcinoma, Squamous Cell Case-Control Studies Cytochrome P-450 CYP1A1 Esophageal Neoplasms Female France Genetic Predisposition to Disease Genotype Glutathione Transferase Humans Male Middle Aged Polymorphism, Genetic Research Support, Non-U.S. Gov't Risk Factors

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