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The double mutations of acvr2aa and acvr2ba leads to muscle hypertrophy in zebrafish

Aquaculture and Fisheries 2023年第6期8卷 706-712页

作者： Jinyuan Che Cunjie Hu Qi Wang Chunxin Fan Yufeng Si Xiaoling Gong Baolong Bao Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources(Shanghai Ocean University) Ministry of EducationInternational Research Center for Marine Biosciences at Shanghai Ocean UniversityMinistry of Science and TechnologyNational Demonstration Center for Experimental Fisheries Science EducationShanghai Ocean UniversityShanghai201306China

Activin A receptor,type II(acvr2)is a member of the transforming growth factor beta receptor family and can function as a negative regulator of skeletal muscle ***2 plays an important role in regulating muscle development that can inhibit skeletal muscle growth in ***,there is very little research reported on the function of acvr2 in muscle development of *** this study,we analyzed the effect of acvr2aa and acvr2ba on muscle development in *** rates of WT and acvr2a^(-/-b-/-)􀀀were measured from juvenile stage to adult *** addition,effects of acvr2 on skeletal muscle were tested in histological,protein and molecular *** a result,acvr2a^(-/-b-/-)􀀀exhibited a wider body trunk than WT and showed a significant increase in body weight and width from two months *** analysis of skeletal muscle indicated that the size of muscle fiber in acvr2a^(-/-b-/-)􀀀(female:1809±123μm^(2);male:2261±130μm^(2))was larger than that in WT(709.8±49μm^(2);815±53μm^(2)).In addition,western blot of fast MyLc protein showed the protein synthesis of acvr2a^(-/-b-/-)􀀀are ***,Histological analysis of heart showed the ventricle area is aslo increased in acvr2a^(-/-b-/-)􀀀.Our results demonstrated acvr2 attends the development of muscle fiber and will cause muscle hypertrophy when they were knocked out in *** conclusion,acvr2 in zebrafish can control the development of muscle fibers during posthatch growth.

关键词： acvr2 Muscle fiber Hypertrophy Zebrafish Skeletal muscle growth

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