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γδT cells aggravate severe H1N1 influenza virus infection induced acute lung injury via secreting IL-17A

γδT cells aggravate severe H1N1 influenza virus infection ...

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第十二届全国免疫学学术大会

作者： Zhang Xulong Xue Chunxue Wen Mingjie Bao Linlin Cao Bin Department of Immunology School of Basic Medical SciencesCapital Medical University Department of Respiratory and Critical Care Medicine Beijing Luhe HospitalCapital Medical University Institute of Laboratory Animal Sciences Chinese Academy of Medical Sciences Department of pulmonary and Critical Care Medicine China-Japan Friendship Hospital

Background:The influenza A(H1N1) pdm09 virus remains a critical global health concern and causes high levels of morbidity and *** acute lung injury(ALI) and acute respiratory distress syndrome(ARDS) are the major outcomes among severely infected ***:Our previous study found that interleukin(IL)-17A production by humans or mice infected with influenza A(H1N1) pdm09 substantially contributes to ALI and subsequent morbidity and ***,the cell types responsible for IL-17A production during the early stage of severe influenza A(H1N1)pdm09 infection remained ***:In this study,a mouse model of severe influenza A(H1N1) pdm09 infection was *** the lungs of infected mice,the percentage of γδT cells,but not the percentages of CD4Th and CD8Tc cells,gradually increased and peaked at 3 days post infection(dpi).Further analysis revealed that the Vγ4γδT subset,but not the Vγ1γδT subset,was significantly increased among the γδT *** 3 dpi,the virus induced significant increases in IL-17A in the bronchoalveolar lavage fluid(BALF) and ***-17A was predominantly secreted by γδT cells(especially the Vγ4γδT subset),but not CD4Th and CD8Tc cells at the early stage of infection,and IL-1β and/or IL-23 were sufficient to induce IL-17A production by γδT *** of γδT cells or the Vγ4γδT subset significantly rescued the virus-induced weight loss and improved the survival rate by decreasing IL-17A secretion and reducing immunopathological ***:This study demonstrated that,by secreting IL-17A,lung Vγ4γδT cells,at least,in part mediated influenza A(H1N1) pdm09-induced immunopathological *** mechanism might serve as a promising new target for the prevention and treatment of ALI induced by influenza A(H1N1) pdm09.

关键词： Influenza γδT cells IL-17A acute pulmonary immunopathological injury

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